Recent seismic events produced considerable socioeconomic losses. An important step for the reduction and mitigation of seismic risk in urban areas with a high population density is the assessment of global vulnerability of clustered buildings. The proposed work aims at appraising the seismic vulnerability of building aggregates within the historical center of Arsita, damaged by the L'Aquila earthquake (2009 April 6th), through a multi-level approach deriving from the application of different estimation procedures. In particular, the seismic vulnerability quantification has been done by comparing three distinct methods, namely the macroseismic approach according to the EMS-98 scale, the Vulnus methodology, developed by the University of Padua, and the mechanical approach derived from using the 3Muri software. The expected damage has been estimated in terms of fragility curves, respectively, for the entire buildings compound and the individual structural units located in the corner and intermediate positions, in order to evaluate the beneficial or detrimental aggregate effect on the seismic behavior of individual constructions examined.