Natural hazards including earthquakes, volcanic eruptions, and tsunamis have been significant threats to humans throughout recorded history. Global navigation satellite systems (GNSS; including the Global Positioning System (GPS)) receivers have become primary sensors to measure signatures associated with natural hazards. These signatures typically include GPS‐derived seismic deformation measurements, coseismic vertical displacements, and real‐time GPS‐derived ocean buoy positioning estimates. Another way to use GPS observables is to compute the ionospheric total electron content (TEC) to measure, model, and monitor postseismic ionospheric disturbances caused by, e.g., earthquakes, volcanic eruptions, and tsunamis. In this paper, we review research progress at the Jet Propulsion Laboratory and elsewhere using examples of ground‐based and spaceborne observation of natural hazards that generated TEC perturbations. We present results for state‐of‐the‐art imaging using ground‐based and spaceborne ionospheric measurements and coupled atmosphere‐ionosphere modeling of ionospheric TEC perturbations. We also report advancements and chart future directions in modeling and inversion techniques to estimate tsunami wave heights and ground surface displacements using TEC measurements and error estimates. Our initial retrievals strongly suggest that both ground‐based and spaceborne GPS remote sensing techniques could play a critical role in detection and imaging of the upper atmosphere signatures of natural hazards including earthquakes and tsunamis. We found that combining ground‐based and spaceborne measurements may be crucial in estimating critical geophysical parameters such as tsunami wave heights and ground surface displacements using TEC observations. The GNSS‐based remote sensing of natural‐hazard‐induced ionospheric disturbances could be applied to and used in operational tsunami and earthquake early warning systems.