Multi-parameter observations, powerful for the study of lithosphere–atmosphere–ionosphere coupling (LAIC), have been performed for a recent Tokyo earthquake (EQ) with a moderate magnitude (M = 5.9) and rather larger depth (~70 km) on 7 October 2021, in the hope of predicting the next Kanto (Tokyo) huge EQ, such as the 1923 Great Kanto EQ (with a magnitude greater than 7). Various possible precursors have been searched during the two-month period of 1 September to 31 October 2021, based on different kinds of data sets: (i) ULF (ultra-low frequency) magnetic data from Kakioka, Japan, (ii) ULF/ELF (extremely low frequency) magnetic field data from the Chubu University network, (iii) meteorological data (temperature and humidity) from the Japan Meteorological Agency (JMA), (iv) AGW (atmospheric gravity wave) ERA5 data provided by the European Centre for Medium-Range Weather Forecast (ECMWF), (v) subionospheric VLF/LF (very low frequency/low frequency) data from Russia and Japan, (vi) ionosonde Japanese data, and (vii) GIM (global ionosphere map) TEC (total electron content) data. After extensive analyses of all of the above data, we have found that there are a few obvious precursors: (i) ULF/ELF electromagnetic radiation in the atmosphere, and (ii) lower ionospheric perturbations (with two independent tools from the ULF depression and subionospheric VLF anomaly) which took place just two days before the EQ. Further, ULF/ELF atmospheric electromagnetic radiation has been observed from approximately one week before the EQ until a few days after the EQ, which seems to be approximately synchronous in time to the anomalous variation in meteorological parameters (a combination of temperature and humidity, atmospheric chemical potential). On the other hand, there have been no clear anomalies detected in the stratospheric AGW activity, and in the NmF2 and TEC data for the upper F region ionosphere. So, it seems that the lithospheric origin is not strong enough to perturb the upper F region. Finally, we discuss the possible hypothesis for the LAIC process, and we can conclude that the AGW hypothesis might be ruled out, but other possible channels such as the chemical channel (radon emanation) and the associated effects might be in operation, at least, for this Tokyo EQ.