Seizure Disorders in Pregnancy

Pschirrer, E. Rebecca; Monga, Manju

doi:10.1016/s0889-8545(05)70221-7

Cited by 33 publications

(5 citation statements)

References 46 publications

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“…[17–19] The outcome of pregnancy is good in majority of gestations, but some studies have reported that the rate of some complications such as hyperemesis gravidarum, preterm labor, pregnancy induced hypertension, preeclampsia, cesarean delivery, placental abruption, and perinatal mortality is higher in these women. [20–22] Also anemia, vaginal bleeding, and stillbirth were thought to be more frequent in these women. [23] In this study the rate of vaginal bleeding was significantly higher in epileptic patients.…”

Section: Discussionmentioning

confidence: 99%

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The course and outcome of pregnancy and neonatal situation in epileptic women

Najafi¹,

Sonbolestan

et al. 2012

Adv Biomed Res

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Background:Epilepsy is a rare neurologic disorder during pregnancy. Despite its rarity, it could cause different clinical problems in this natural phenomenon of a woman's life. The aim of this study was to evaluate and compare the course of pregnancy and labor and their outcome in epileptic and healthy women.Materials and Methods:This study was performed during years 2009--2011 in Alzahra and Beheshti hospitals affiliated to Isfahan University of Medical Sciences. A total of 51 pregnant women, who were known cases of epilepsy and were on antiepileptic drugs treatment for at least 3 months, were compared with 47 matched healthy pregnant women without epilepsy. They were followed before and during their pregnancy in several visits and all of their neurologic and obstetric information were collected. For statistical analysis of continuous variables, the t-test was used. The chi-square test was used for dichotomous variables.Results:The rate of monotherapy was more than polytheraphy especially during the pregnancy. The epileptic attacks stopped in majority of patients during the pregnancy. Vaginal bleeding (P=0.020) and abortion (P=0.015) were significantly more frequent among epileptic mothers. The gestational age was lower meaningfully (P= 0.010) in epileptic patients’ neonates and the first minute Apgar score was lower in these babies too (P=0.028).Conclusions:Antiepileptic drugs could have some unsuitable effects on pregnancy course especially by increasing the rate of abortion, preterm labor, and vaginal bleeding. Their adverse effects on neonates’ health could not be neglected.

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Section: Discussionmentioning

confidence: 99%

“…It could support the previous studies which reported higher rates of preterm labor in these patients. [20–22]…”

Section: Discussionmentioning

confidence: 99%

The course and outcome of pregnancy and neonatal situation in epileptic women

Najafi¹,

Sonbolestan

et al. 2012

Adv Biomed Res

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“…Recommendations vary on how often to measure phenytoin levels during pregnancy. Although some experts advocate measuring levels more than once per trimester, 10 frequent measurements may lead to increasing a dose unnecessarily and creating drug toxicity 8 . Both the total and free levels of phenytoin should be measured, because the free levels will be higher during pregnancy 5 .…”

Section: Effect Of Phenytoin Use During Pregnancymentioning

confidence: 99%

“…The American Academy of Neurologists recommends that a non‐protein‐bound (free) serum drug level be obtained once a trimester and during the last month of pregnancy 11 . Blood should be drawn just before the next dose is due so that a trough level can be assessed 10,11 . The lowest possible effective dose should be prescribed 9 .…”

Section: Effect Of Phenytoin Use During Pregnancymentioning

confidence: 99%

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Use of Phenytoin in Pregnancy for Epileptic Seizure Prevention: A Case Report

Fitzgerald

2004

J Midwife Womens Health

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Epilepsy is the most common neurological disorder in women of reproductive age. Phenytoin is one of the most frequently prescribed antiepileptic drugs. Although the vast majority of women with epilepsy have normal pregnancy outcomes, certain fetal anomalies and pregnancy complications are associated with epilepsy and phenytoin use. Appropriate midwifery care of women with epilepsy includes consultation and co-management with an obstetrician and a neurologist. The clinical course of a woman with epilepsy taking phenytoin is presented.

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Epilepsy

Pennell¹

2007

Management of High‐Risk Pregnancy

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Seizure Disorders in Pregnancy

Cited by 33 publications

References 46 publications

The course and outcome of pregnancy and neonatal situation in epileptic women

The course and outcome of pregnancy and neonatal situation in epileptic women

Use of Phenytoin in Pregnancy for Epileptic Seizure Prevention: A Case Report

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