Seizure in Indonesian Glioma Patients: Associated Risk Factors and Impact on Survival

Hartanto, Rachmat Andi; Dwianingsih, Ery Kus; Panggabean, Andre Stefanus; Wicaksono, Adiguno Suryo; Dananjoyo, Kusumo; Asmedi, Ahmad; Malueka, Rusdy Ghazali

doi:10.31557/apjcp.2021.22.3.691

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…In gliomas, miR-494 can overregulate the PTEN/Akt signaling pathway to promote glioma cell proliferation, invasiveness and migration. In breast cancer, miR-494 exerts a breast cancer inhibitory effect by regulating the WNT/β-catenin signaling pathway (1,2). MiRNA mainly exerts its biological effects by regulating downstream target genes, so the downstream target genes determine the role of miRNA (3).…”

Section: Introductionmentioning

confidence: 99%

MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1

Zhang

2022

Cell Mol Biol (Noisy-le-grand)

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LETMD1 is a differentially expressed gene selected by scientists from cervical cancer (CC) tissues by RT-PCR technology. It has been confirmed that LETMD1 is overexpressed in many human malignant tumors, so it can be used as an early diagnostic marker for malignant tumors and as a target for gene therapy. The purpose of this article is to further explore the effectiveness of miR-494 in inhibiting the proliferation, migration and invasion of CC cells by regulating LETMD1, selecting 40 cases of CC admitted to a hospital from June 2015 to September 2018 Patients, tumor tissue specimens were taken from the primary tumor tissue of CC, and normal tissues near the cutting edge were collected as controls. Normal tissues were confirmed by pathology after surgery that they were not invaded by cancer tissues. The results of the study showed that the expression level of miR-494 increased by 15%, and the prognostic survival rate after surgery increased by 20%, depending on gender, age, tumor size, and tumor site. After high expression of miR-494 in CC patients, the vascular invasion of CC cells was reduced by 33%, and distant metastasis was reduced by 11%, and the survival time of patients was significantly prolonged. After the expression of LETMD1, the proportion of cancer cells decreased by 5%, the proportion of macrophages increased by 2%, and the dendritic cells increased by 3%.

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Section: Introductionmentioning

confidence: 99%

MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1

Zhang

2022

Cell Mol Biol (Noisy-le-grand)

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“…The main clinical types of glioma include astrocytoma, retinoblastoma and oligodendroglioma (1). The treatment and prognosis of glioma vary according to the type of glioma (2,3).…”

Section: Introductionmentioning

confidence: 99%

Long-stranded non-coding RNA HCG11 regulates glioma cell proliferation, apoptosis and drug resistance via the sponge MicroRNA-144COX-2 axis

Jiang

Zhou

Zhang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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In the current study, we analyzed long non-coding RNA HCG11 regulates the proliferation, apoptosis and drug resistance of glioma cells by spongy microRNA-144COX-2 axis. For this purpose, glioma cells at the logarithmic growth stage were divided into blank, up-regulated and down-regulated groups. The blank group did not undergo any treatment. Bacteria were inserted into the complete culture medium of the up-regulated group and down-regulated group for co-culture for 24 h. The down-regulated group was transfected with Mir-HCG11 inhibitor. The expressions of Mir-HCG11, Mir-144-3p and COX-2 in each group were observed, and the proliferation and apoptosis of glioma cells were analyzed, and their drug resistance was analyzed. Results showed that compared with the blank group, the expression of Mir-HCG11 and Mir-144 was increased and the expression of COX-2 was decreased in the up-regulated group (P < 0.05). Compared with the up-regulated group, the down-regulated group increased the expression of Mir-HCG11 and Mir-144 and decreased the expression of COX-2 (P < 0.05). Compared with the blank group, the proliferation rate of glioma cells in the up-regulated group (24h, 48h, 72h) was increased (P < 0.05); Compared with the up-regulated group, the proliferation rate of glioma cells in the down-regulated group (24h, 48h, 72h) was decreased (P < 0.05); Compared with the blank group, apoptosis rate of glioma cells in the up-regulated group (24h, 48h, 72h) was decreased (P < 0.05); Compared with the up-regulated group, the apoptosis rate of glioma cells in the down-regulated group (24h, 48h, 72h) was increased (P < 0.05); The IC50 values of Imatinib, VP-16 and TMZ in blank group and up-regulated group was compared (P > 0.05). Compared with the blank group and up-regulated group, the IC50 values of Imatinib, VP-16 and TMZ in the down-regulated group were decreased (P < 0.05). In general, down-regulation of long non-coding RNA-HCG11 can regulate the microRNA-144COX-2 axis in glioma, thus reducing the proliferation rate of glioma cells and improving the apoptosis rate of glioma cells. In addition, down-regulation of long non-coding RNA-HCG11 is also involved in the drug resistance mechanism of Imatinib, VP-16 and TMZ chemotherapy drugs.

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“…Seizures are the presenting symptom in approximately two-thirds of patients with oligodendrogliomas [ 7 ]. Patients with this type of neoplasm may also present with headaches due to increased intracranial pressure and focal neurological deficit, depending on the location of the tumor.…”

Section: Introductionmentioning

confidence: 99%

A Patient With Epilepsy, Ganglioglioma, and Oligodendroglioma With Anaplastic Foci in the Same Left Frontoparietal Lesion: A Case Report

Aguilar-Hidalgo¹,

Alvarez-Castro²,

Santellán-Hernández³

et al. 2022

Cureus

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Gangliogliomas are central nervous system (CNS) tumors with a neuronal and glial component considered grade 1 according to the World Health Organization (WHO) classification. On the other hand, oligodendrogliomas are diffuse infiltrating gliomas (CNS WHO grade 2 or 3) characterized by both an isocitrate dehydrogenase mutation and 1p/19q co-deletion. There have been some cases with the coexistence of these two tumors. Here, we present the case of a low-growing left frontoparietal brain tumor with a definite diagnosis of ganglioglioma (CNS WHO grade 1) and oligodendroglioma (CNS WHO grade 2) with areas of anaplastic oligodendroglioma (CNS WHO grade 3) in a patient with long-standing epilepsy.

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Seizure in Indonesian Glioma Patients: Associated Risk Factors and Impact on Survival

Cited by 5 publications

References 32 publications

MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1

MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1

Long-stranded non-coding RNA HCG11 regulates glioma cell proliferation, apoptosis and drug resistance via the sponge MicroRNA-144COX-2 axis

A Patient With Epilepsy, Ganglioglioma, and Oligodendroglioma With Anaplastic Foci in the Same Left Frontoparietal Lesion: A Case Report

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