Seizures in patients with cancer

Castro, L Nicolas Gonzalez; Milligan, Tracey

doi:10.1002/cncr.32708

Cited by 24 publications

(23 citation statements)

References 93 publications

(183 reference statements)

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“…Seizures lead to the initial presentation of 20-40% of patients with glioma (more common in IDH-mutant gliomas). 10,11 On the other hand, seizures are rare in MS; a pooled analysis of 39 studies found the prevalence of seizures and epilepsy in MS patients to be 2% and 3%, respectively. 12 As with MS, gliomas may cause focal neurologic deficits depending on the size and location of the tumor and on the amount of vasogenic edema.…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma in Patients With Multiple Sclerosis

Berkman

Nakhate

Castro

2022

The Neurohospitalist

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Background Although rare, the co-occurrence of multiple sclerosis (MS) and glioma poses unique challenges in terms of diagnosis and management for both neurologists and neuro-oncologists. Methods Here we report on a single-center cohort of four patients with a diagnosis of multiple sclerosis who developed gliomas. Results Our cohort reflects the epidemiology of glioma in terms of the relative frequency of IDH-wildtype and IDH-mutant cases. The patients in 3 out of the 4 cases presented did not develop their tumors in areas of pre-existing demyelinating lesions. Conclusions We did not find evidence to support the hypothesis that chronic gliosis from demyelinating plaques may serve as a substrate for secondary induction of a glial neoplasm. In our Discussion, we provide recommendations for distinguishing neoplastic from demyelinating lesions, review the evidence for demyelination as a risk factor for gliomagenesis, and highlight important considerations for the concurrent management of glioma and MS.

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Section: Discussionmentioning

confidence: 99%

Glioblastoma in Patients With Multiple Sclerosis

Berkman

Nakhate

Castro

2022

The Neurohospitalist

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“… 15 Moreover, seizures may occur in patients with many types of cancer, including in those without brain lesions. 16 …”

Section: Introductionmentioning

confidence: 99%

“…Central nervous system malignancies cause seizures in 35%–70% of patients, who often present with resistance to antiepileptics 15 . Moreover, seizures may occur in patients with many types of cancer, including in those without brain lesions 16 …”

Section: Introductionmentioning

confidence: 99%

Controlled register‐based study of road traffic accidents in 12,651 Finnish cancer patients during 2013–2019

Huuskonen

Koistinen

Sihvola³

et al. 2022

Cancer Medicine

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Background: Little controlled evidence exists on road traffic accident (RTA) risk among patients diagnosed with cancer, while clinicians are often requested to comment their ability to drive. The aim of this study was to evaluate RTA risk in a population-based cohort of cancer patients living in Southwest Finland.Patients: All adult patients diagnosed with cancer in 2013-2019 were included.Acute appendectomy/cholecystectomy and actinic keratosis patients without cancer were selected from the same region as the control cohort. Participants were cross-referenced to a national driving licence database, yielding 12,651 cancer and 6334 control patients with a valid licence. Due to marked differences in their clinical presentation, the cancer cohort was divided into nine cancers of interest (breast, prostate, colorectal, lung, melanoma, head & neck, primary brain tumours, gynaecological and haematological malignancies). The nationwide lawregulated motor liability insurance registry was searched for all RTAs leading to injury with claims paid to not-or at-fault participants. At-fault drivers were verified based on sex and birth year.Results: During a median follow-up of 34 months, 167 persons were at-fault drivers in RTAs leading to injury. Among the nine cancers of interest, RTA risk did not differ from the control cohort. Among cancer patients, multivariable regression suggested male sex and opioid use, but not advanced cancer stage or given systemic therapy, as the most influential risk factors for RTA.Conclusions: Cancer diagnosis itself was not associated with increased RTA risk, but other associated symptoms, medications, comorbidities or specific cancer subgroups may.

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“…During their illness, many patients who have cancer experience seizures, with the incidence varying according to the type of tumor. Low-grade gliomas (LGG) ranked third among them 14 . Although LGG (astrocytomas, oligodendrogliomas, and oligoastrocytomas) are considered relatively benign, well-differentiated tumors and have 5-year survival rates of 59.9%, approximately 70% of LGG patients develop GBM within 5–10 years 15 .…”

Section: Introductionmentioning

confidence: 99%

Identification of Hub Genes of Mesio Temporal Lobe Epilepsy and Prognostic Biomarkers of Brain Low-grade Gliomas Based on Bioinformatics Analysis

Sun

Wang

et al. 2020

Cell Transplant

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Mesio temporal lobe epilepsy (MTLE) syndrome is the most common form of intractable epilepsies. Meanwhile, seizures are common in patients with cancer as a consequence of brain tumors, including brain low-grade gliomas (LGG). However, the underlying molecular mechanisms of MTLE remain poorly understood. Also, the relationship between MTLE and LGG needs our attention. In this study, we aimed to investigate the hub genes and potential mechanism in MTLE, and the relationship between MTLE and LGG, the gene expression profiles (GSE88992) were downloaded from the Gene Expression Omnibus (GEO) database. Difference analysis for MTLE versus control groups under the three time points was conducted to select the differentially expressed genes (DEGs). Time series clustering analysis was used to select the trend genes. Then a series of bioinformatics analyses including functional enrichment analysis, protein–protein interaction (PPI) network and module analyses, and transcription factor (TF) and miRNA prediction were performed. Also, the overall survival analysis and expression of hub genes in LGG were performed using UALCAN from TCGA database. At 6 h, there were 351 upregulated and 80 downregulated DEGs. At 12 h, there were 499 upregulated and 231 downregulated DEGs. Additionally, 532 upregulated and 402 downregulated DEGs were obtained at 24 h. After time series clustering analysis of the DEGs, we obtained 323 uptrend and 248 downtrend genes. We identified 10 key genes with higher degrees, including C3, TIMP1, PENK, CKAP4, etc. Five PPI modules were identified by MCODE. TF analysis predicted four TFs: JUN, STAT3, NR4A2, and Myc. A total of 26,834 miRNA–mRNA pairs were predicted. Moreover, survival analysis of UALCAN suggested that C3, TIMP1, PENK, GNG2, CKAP4, TNC, JUN, STAT3, NR4A2, and Myc can be potential biomarkers for the prognosis of LGG. In summary, DEGs and hub genes were identified in the present study, which provides novel insight into the development of MTLE.

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Seizures in patients with cancer

Cited by 24 publications

References 93 publications

Glioblastoma in Patients With Multiple Sclerosis

Glioblastoma in Patients With Multiple Sclerosis

Controlled register‐based study of road traffic accidents in 12,651 Finnish cancer patients during 2013–2019

Identification of Hub Genes of Mesio Temporal Lobe Epilepsy and Prognostic Biomarkers of Brain Low-grade Gliomas Based on Bioinformatics Analysis

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