“…Central fatigue, originating in the brain by an excitation < inhibition dysbalance is assumed during prolonged exhaustive exercise and in overtrained athletes (23,27,38), based on a plasma (serum) amino acid imbalance (5,6,9.27,30,31.38) which in part resembles the amino acid profile in patients suffering from hepatic encephalopathy (32). The BCAA (leucine, isoleucine, valine) were found to remain unchanged after completing a marathon (5) or to be reduced after a 30 km run, a marathon (2, 29,30), and a 100 km-run (6) combined…”