Selected biochemical and oxidative stress parameters and ceruloplasmin as acute phase protein associated with bovine leukaemia virus infection in dairy cows

Abstract

The aim of this study was to determine the ceruloplasmin (Cp) and vitamin C concentrations, the total antioxidant status (TAS), and selected biochemical parameters in dairy cows spontaneously infected with bovine leukaemia virus (BLV). Of the 27 cows included in the study, 18 animals were seropositive for enzootic bovine leukosis (EBL), whereas nine cows were seronegative and were used as controls. The serum aspartate aminotransferase (AST) (P = 0.003) and Cp concentrations (P = 0.03) decreased (65.17 ± 5.03 and 7.70 ± 0.72 respectively) in BLV-infected cows, as compared to healthy animals (100.67 ± 11.50 and 10.40 ± 0.70 respectively). A slight insignificant increase in alkaline phosphatase activity and unchanged levels of alanine aminotransferase, lactate dehydrogenase, calcium, magnesium, and TAS were demonstrated in EBL cows. As the TAS and vitamin C levels remained unchanged in EBL cows, it may be suggested that ruminants may compensate for the impaired oxidative/antioxidative balance. The results obtained also indicate that BLV may suppress AST and Cp synthesis or secretion in the liver through an unknown mechanism. The mechanism of action of BLV in hepatocytes, especially on AST and Cp, requires further investigation to elucidate the immune suppression caused by oncogenic retroviruses.

Haptoglobin, serum amyloid A and ceruloplasmin concentrations in cattle with suspicion of coryza gangrenosa bovum

“…In this study, serum hp, Saa and Cp concentrations were determined in the animals in the control group (table 2) while these values were seen to be within the scope of the limits indicated for healthy cattle by other researchers (AKALIN et al, 2015;AYTEKIN et al, 2016;BASBUG et al, 2016;CHAN et al, 2004;ECKERSALL and CONNER, 1988;HUSSEIN et al, 2012;NAZIFI et al, 2009;NISBET et al, 2008;SKINNER, 2001;ULUTAS et al, 2011).…”

“…also, an important correlation was detected between the clinical appearance of the disease and hp and Saa. akaLIN et al (2015) reported that Cp levels decreased in dairy cattle infected with bovine leukemia virus and this affected Cp synthesis of bovine leukemia virus, or it might suppress Cp secretion in the liver due to an unknown mechanism.…”

Serum Biochemistry of Lumpy Skin Disease Virus-Infected Cattle

“…The measurement and evaluation of the biochemical profile may be helpful in elucidating the pathogenesis and prognosis of the disease. Significant changes occur in the blood biochemical parameters of the animals exposed to viral diseases [ 31 – 33 ]. It has been reported that elevated serum cardiac troponin I is associated with myocardial injury during foot-and-mouth disease virus infection [ 34 ].…”

Impact of the copper industry on the content of selected heavy metals and biochemical indicators in the blood of dairy cows

“…zakażenie wirusem opryszczki bydła (BoHV-1) (16). Z kolei infekcja wirusem białaczki bydła istotnie obniża stężenie AST, bez wpływu na poziom LDH (1).…”

“…Z dostępnej literatury (1,18,48) wynika, że system utrzymania, pora roku, poziom laktacji czy nawet stan zdrowotny wywierają na ogół niewielki wpływ na koncentrację makroelementów w surowicy krwi krów. Wydaje się, że koncentracja głównych makroskładników w surowicy może ulegać niekorzystnym fizjologicznie zmianom, gdy niezbilansowany jest poziom żywienia mineralnego, np.…”