Selected Mutations by Nemonoxacin and Fluoroquinolone Exposure Among Relevant Gram-Positive Bacterial Strains in Taiwan

Yang, Jen-Jia; Cheng, Aristine; Tai, Hui-Ming; Chang, Li-Wen; Hsu, Ming‐Chu; Sheng, Wang‐Huei

doi:10.1089/mdr.2019.0048

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…Staphylococcus aureus can become drug-resistant by genetic mutations that alter the target DNA gyrase or reduce outer membrane proteins, thereby reducing drug accumulation (Kime et al, 2019;Yang et al, 2019). For example, the principle of resistance to clindamycin and erythromycin is caused by a modification in ribosomal RNA methylase (Heelan et al, 2004;Martinez et al, 2018).…”

Section: Resistance By Mutationsmentioning

confidence: 99%

Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus

Guo

Song

Sun

et al. 2020

Front. Cell. Infect. Microbiol.

551

350

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Infectious diseases are the second most important cause of human death worldwide; Staphylococcus aureus (S. aureus) is a very common human pathogenic microorganism that can trigger a variety of infectious diseases, such as skin and soft tissue infections, endocarditis, osteomyelitis, bacteremia, and lethal pneumonia. Moreover, according to the sensitivity to antibiotic drugs, S. aureus can be divided into methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). In recent decades, due to the evolution of bacteria and the abuse of antibiotics, the drug resistance of S. aureus has gradually increased, the infection rate of MRSA has increased worldwide, and the clinical anti-infective treatment for MRSA has become more difficult. Accumulating evidence has demonstrated that the resistance mechanisms of S. aureus are very complex, especially for MRSA, which is resistant to many kinds of antibiotics. Therefore, understanding the drug resistance of MRSA in a timely manner and elucidating its drug resistance mechanism at the molecular level are of great significance for the treatment of S. aureus infection. A large number of researchers believe that analyzing the molecular characteristics of S. aureus can help provide a basis for designing effective prevention and treatment measures against hospital infections caused by S. aureus and further monitor the evolution of S. aureus. This paper reviews the research status of MSSA and MRSA, the detailed mechanisms of the intrinsic antibiotic resistance and the acquired antibiotic resistance, the advanced research on anti-MRSA antibiotics and novel therapeutic strategies for MRSA treatment.

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Section: Resistance By Mutationsmentioning

confidence: 99%

Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus

Guo

Song

Sun

et al. 2020

Front. Cell. Infect. Microbiol.

551

350

View full text Add to dashboard Cite

show abstract

“…S. aureus can become resistant to antibiotics through genetic mutations that alter the target DNA gyrase or reduce outer membrane proteins, thus reducing drug accumulation [ 46 , 47 ]. Martin et al [ 48 ] reported a marked increase in resistance to trimethoprim-sulfamethoxazole in clinical isolates of Staphylococcus aureus and 7 genera of Enterobacteriaceae, including E. coli , from 1988-1995 at a hospital in California.…”

Section: Resultsmentioning

confidence: 99%

Potentiation of the Activity of Antibiotics against ATCC and MDR Bacterial Strains with (+)-α-Pinene and (-)-Borneol

Leite-Sampaio

Gondim

Martins

et al. 2022

BioMed Research International

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The increasing rates of antimicrobial resistance have demanded the development of new drugs as conventional antibiotics have become significantly less effective. Evidence has identified a variety of phytocompounds with the potential to be used in the combat of infections caused by multidrug-resistant (MDR) bacteria. Considering the verification that terpenes are promising antibacterial compounds, the present research aimed to evaluate the antibacterial and antibiotic-modulating activity of (+)-α-pinene and (-)-borneol against MDR bacterial strains. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the compounds and antibiotics and further evaluate the intrinsic and associated antibiotic activity. These analyses revealed that (+)-α-pinene showed significant antibacterial activity only against E. coli ( MIC = 512 μ g . m L − 1 ), while no significant inhibition of S. aureus and P. aeruginosa growth was observed ( MIC ≥ 1024 μ g m L − 1 ). However, when combined with antibiotics, this compound induced a significant improvement in the activity of conventional antibiotics, as observed for ciprofloxacin, amikacin, and gentamicin against Staphylococcus aureus, as well as for amikacin and gentamicin against Escherichia coli, and amikacin against Pseudomonas aeruginosa. On the other hand, (-)-borneol was found to inhibit the growth of E. coli and enhance the antibiotic activity of ciprofloxacin and gentamicin against S. aureus. The present findings indicate that (+)-α-pinene and (-)-borneol are phytocompounds with the potential to be used in the combat of antibacterial resistance.

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“…One of these was used for experiments on the evolution of β-lactamase, where the antibiotic resistance protein TEM-1 evolved towards resisting the antibiotic cefotaxime in an E. coli strain with a high mistranslation rate [39]. Other experiments have demonstrated that substitutions at residues 69, 130, 165, 244, 275, and 276 from bla TEM-1 are all believed to play an exclusive role in inhibitor resistance [40,41], and most of them are found at a high frequency in the dataset of clinical isolates. However, it is worth noting that the TV1 substitution with respect to TV2 occurs at residue 116.…”

Section: Discussionmentioning

confidence: 99%

Beta-Lactam Antibiotic Resistance Genes in the Microbiome of the Public Transport System of Quito, Ecuador

Hernández-Alomía

Bastidas-Caldes

Ballesteros

et al. 2023

IJERPH

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Multidrug-resistant bacteria present resistance mechanisms against β-lactam antibiotics, such as Extended-Spectrum Beta-lactamases (ESBL) and Metallo-β-lactamases enzymes (MBLs) which are operon encoded in Gram-negative species. Likewise, Gram-positive bacteria have evolved other mechanisms through mec genes, which encode modified penicillin-binding proteins (PBP2). This study aimed to determine the presence and spread of β-lactam antibiotic resistance genes and the microbiome circulating in Quito’s Public Transport (QTP). A total of 29 station turnstiles were swabbed to extract the surface environmental DNA. PCRs were performed to detect the presence of 13 antibiotic resistance genes and to identify and to amplify 16S rDNA for barcoding, followed by clone analysis, Sanger sequencing, and BLAST search. ESBL genes blaTEM-1 and blaCTX-M-1 and MBL genes blaOXA-181 and mecA were detected along QPT stations, blaTEM being the most widely spread. Two subvariants were found for blaTEM-1, blaCTX-M-1, and blaOXA-181. Almost half of the circulating bacteria found at QPT stations were common human microbiota species, including those classified by the WHO as pathogens of critical and high-priority surveillance. β-lactam antibiotic resistance genes are prevalent throughout QPT. This is the first report of blaOXA-181 in environmental samples in Ecuador. Moreover, we detected a new putative variant of this gene. Some commensal coagulase-negative bacteria may have a role as mecA resistance reservoirs.

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Selected Mutations by Nemonoxacin and Fluoroquinolone Exposure Among Relevant Gram-Positive Bacterial Strains in Taiwan

Cited by 9 publications

References 21 publications

Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus

Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus

Potentiation of the Activity of Antibiotics against ATCC and MDR Bacterial Strains with (+)-α-Pinene and (-)-Borneol

Beta-Lactam Antibiotic Resistance Genes in the Microbiome of the Public Transport System of Quito, Ecuador

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