Selection and characterisation of a xylitol-derepressed Aspergillus niger mutant that is apparently impaired in xylitol transport

Vondervoort, Peter J. I. van de; Groot, M.J.; Ruijter, George J. G.; Visser, Jaap

doi:10.1007/s00253-006-0527-y

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Moreover, L-arabinose is a major component of sugars present in several specialized feedstocks that are produced in large amounts every year. For example, L-arabinose constitutes 32% of the sugars in spent brewery grains (Carvalheiro et al 2004), 28% in corn fiber (Park et al 2001), 13.5% in wheat bran (Palmarola-Adrados et al 2005), and 6.6% in rice straw (Sulbaran-de-Ferrer et al 2003). Thus, conversion of L-arabinose to ethanol would greatly increase the economic viability of biomass to ethanol fermentation.…”

Section: Introductionmentioning

confidence: 98%

Utilization and transport of l-arabinose by non-Saccharomyces yeasts

et al. 2009

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L-Arabinose is one of the sugars found in hemicellulose, a major component of plant cell walls. The ability to convert L-arabinose to ethanol would improve the economics of biomass to ethanol fermentations. One of the limitations for L-arabinose fermentation in the current engineered Saccharomyces cerevisiae strains is poor transport of the sugar. To better understand L-arabinose transport and use in yeasts and to identify a source for efficient L-arabinose transporters, 165 non-Saccharomyces yeast strains were studied. These yeast strains were arranged into six groups based on the minimum time required to utilize 20 g/L of L-arabinose. Initial transport rates of L-arabinose were determined for several species and a more comprehensive transport study was done in four selected species. Detailed transport kinetics in Arxula adeninivorans suggested both low and high affinity components while Debaryomyces hansenii var. fabryii, Kluyveromyces marxianus and Pichia guilliermondii possessed a single component, high affinity active transport systems.

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Section: Introductionmentioning

confidence: 98%

Utilization and transport of l-arabinose by non-Saccharomyces yeasts

et al. 2009

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Bioconversion of d-xylose to d-xylonate with Kluyveromyces lactis

Nygård

Toivari

Penttilä

et al. 2011

Metabolic Engineering

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Incidence and Risk Factors of Lumbosacral Complications Following Long‐Segment Spinal Fusion in Adult Degenerative Scoliosis

Jiang,

Zhang,

et al. 2024

Orthopaedic Surgery

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PurposeLong‐segment spinal fusions are associated with lumbosacral complications (LSC), but the associated risk factors are not known. This study aimed to identify the risk factors for LSC after long‐segment instrumented fusion with distal fixation to the L5 vertebral body in adult degenerative scoliosis (ADS).MethodsWe retrospectively evaluated 294 patients with ADS who underwent long‐segment floating fusion between January 2014 and March 2022, with follow‐up for at least 2 years. Patients were matched to the baseline data using fusion level > 5 as a grouping variable. Patients who completed matching were divided into two groups according to the presence or absence of LSC. Univariate logistic regression was applied to identify potential risk factors for LSC, and multivariate logistic regression was used to identify independent risk factors for postoperative LSC.ResultsThe overall incidence of LSC was 21.77% in the 294 patients, with disc degeneration in 28 (9.52%) and radiographic ASD in 44 (14.97%) patients. The mean time to LSC development after surgery was 26.91 ± 8.43 months. A total of 54 pairs of patients were matched and grouped, and the complication group had higher Oswestry Disability Index (ODI) and visual analog scale (VAS) scores at the last follow‐up. Multivariate analysis showed that gender (OR = 0.274, p = 0.026 [0.087, 0.859]); levels of fusion > 5 (OR = 3.127, p = 0.029 [1.120, 8.730]), main curve correction rate (OR = 0.009, p = 0.005 [0.000, 0.330]), and postoperative pelvic incidence minus lumbar lordosis (PI‐LL) > 15° (OR = 3.346, p = 0.022 [1.195, 9.373]) were independent risk factors for postoperative LSC. The area under the curve value of the prediction model was 0.804, with a 95% confidence interval of 0.715–0.892, indicating that the model had a high prediction accuracy. Collinearity statistics showed no collinearity between variables.ConclusionSex, level of fusion > 5, main curve correction rate, and postoperative PI‐LL > 15° were independent risk factors for the development of LSC after long‐segment floating fusion. These results will improve our ability to predict personal risk conditions and provide better medical optimisation for surgery.

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Selection and characterisation of a xylitol-derepressed Aspergillus niger mutant that is apparently impaired in xylitol transport

Cited by 3 publications

References 21 publications

Utilization and transport of l-arabinose by non-Saccharomyces yeasts

Utilization and transport of l-arabinose by non-Saccharomyces yeasts

Bioconversion of d-xylose to d-xylonate with Kluyveromyces lactis

Incidence and Risk Factors of Lumbosacral Complications Following Long‐Segment Spinal Fusion in Adult Degenerative Scoliosis

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