We describe a framework for understanding how age-related changes in adult development affect work motivation, and, building on recent lifespan theories and research on cognitive abilities, personality, affect, vocational interests, values, and self-concept, identify four intraindividual change trajectories (loss, gain, reorganization, and exchange). We discuss implications of the integrative framework for the use and effectiveness of different motivational strategies with midlife and older workers in a variety of jobs, as well as abiding issues and future research directions.