Selection of Appropriate Computed Tomographic Image Reconstruction Algorithms for a Quantitative Multicenter Trial of Diffuse Lung Disease

Zhang, Jie; Bruesewitz, Michael R.; Bartholmai, Brian J.; McCollough, Cynthia H.

doi:10.1097/rct.0b013e3180690d89

Cited by 15 publications

(10 citation statements)

References 10 publications

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“…These studies included a variety of acquisition techniques depending upon whether the images were obtained for clinical purposes prior to LTRC enrollment, or whether the studies were obtained prospectively according to the high-resolution CT techniques specifically designed by the LTRC radiology core laboratory. 12 All prospective scans using the LTRC protocol were obtained using either General Electric (GE) or Siemens scanners with 16 or more detectors, and imaging parameters were standardized as much as possible among the enrollment centers (with slice thickness 1.25 mm or less with 50% overlapping reconstruction in a high spatial frequency-preserving algorithm). For viewing and analysis of both retrospective clinical scans and LTRC protocol scans, the acquisition with the thinnest slice reconstruction obtained during supine inspiration was utilized for evaluation of emphysema and other parenchymal abnormalities.…”

Section: Methodsmentioning

confidence: 99%

Correlation of Regional Emphysema and Lung Cancer: A Lung Tissue Research Consortium-Based Study

Hohberger¹,

Schroeder

Bartholmai

et al. 2014

Journal of Thoracic Oncology

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Background Chronic obstructive pulmonary disease (COPD) and lung cancer are linked since both airflow obstruction and emphysema, on computer tomography (CT), are independent risk factors for lung cancer. However, the local risk of malignancy relative to development of regional emphysema has not yet been defined. Specifically, it is not known if primary lung cancers are associated with regions of worse emphysema within individual patients. Methods We performed a database analysis evaluating the association between the degree of regional emphysema as scored on CT and development of primary lung cancer. We also studied the association between regional emphysema and benign lung nodules. We assembled two distinct cohorts using the National Heart, Lung, and Blood Institute’s Lung Tissue Research Consortium (LTRC) database, hypothesizing that lung malignancy will preferentially locate in the regions of the most severe emphysema. Results In the LTRC database, 624 cases met criteria for the malignant nodule cohort, and 64 were included in the benign nodule cohort. When comparing location of a malignant nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of lung cancer was 1.342 (95% CI 1.112–1.620; p=0.0022). When comparing location of a benign nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of the benign nodule was 1.118 (95% CI 0.725–1.725; p=0.6137). Conclusions Primary lung cancers are associated with areas of worse regional emphysema.

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Section: Methodsmentioning

confidence: 99%

Correlation of Regional Emphysema and Lung Cancer: A Lung Tissue Research Consortium-Based Study

Hohberger¹,

Schroeder

Bartholmai

et al. 2014

Journal of Thoracic Oncology

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“…Images were reconstructed to encompass the entire lung field in a 512×512 pixel matrix using the GE “bone” kernel at 0.625-mm section thickness and 0.625-mm interval. The “bone” kernel was used because of its ability to analyze both the parenchyma and airways [16]. …”

Section: Methodsmentioning

confidence: 99%

“…Examples demonstrating the performance of the computerised schemes [16–18] in lobe identification in the presence of severe emphysema (GOLD = 4 for all three examples). Each row shows a different CT examination.…”

Section: Figmentioning

confidence: 99%

Optimal threshold in CT quantification of emphysema

et al. 2012

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Objectives To determine the optimal threshold by quantitatively assessing the extent of emphysema at the level of the entire lung and at the level of individual lobes using a large, diverse dataset of CT examinations. Methods This study comprises 573 chest CT examinations acquired from different subjects (222 none, 83 mild, 141 moderate, 63 severe, and 64 very severe obstruction). The extent of emphysema was quantified using the percentage of the low attenuation area (LAA%) divided by the total lung or lobe volume(s). The correlations between the extent of emphysema, and pulmonary functions and the five-category classification were assessed using Pearson and Spearman’s correlation coefficients, respectively. When quantifying emphysema using a density mask, a wide range of thresholds from −850 to −1000 HU were used. Results The highest correlations of LAA% with the five-category classification and PFT measures ranged from −925 to −965 HU for each individual lobe and the entire lung. However, the differences between the highest r and those obtained at −950 HU are relatively small. Conclusion Although there are variations in the optimal cut-off thresholds for individual lobes, the single threshold of −950 HU is still an acceptable threshold for density-based emphysema quantification.

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“…The radiology core laboratory defined CT protocols for LTRC 27. CT scanners follow the American College of Radiology guidelines for accreditation (www.acr.org/accreditation/computed/).…”

Section: Methodsmentioning

confidence: 99%

Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD

Díaz

Bartholmai

Estépar

et al. 2010

Respiratory Medicine

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SUMMARY Objective To assess the association of emphysema and airway disease assessed by volumetric computed tomography (CT) with exercise capacity in subjects with chronic obstructive pulmonary disease (COPD). Methods We studied 93 subjects with COPD (Forced Expiratory Volume in 1 s [FEV1] %predicted mean ± SD 57.1 ± 24.3%, female gender = 40) enrolled in the Lung Tissue Research Consortium. Emphysema was defined as percentage of low attenuation areas less than a threshold of −950 Hounsfield units (%LAA-950) on CT scan. The wall area percentage (WA%) of the 3rd to 6th generations of the apical bronchus of right upper lobe (RB1) were analyzed. The six-minute walk distance (6MWD) test was used as a measure of exercise capacity. Results The 6MWD was inversely associated with %LAA-950 (r = −0.53, p<0.0001) and with the WA% of 6th generation of RB1 only (r = −0.28, p = 0.009). In a multivariate regression model including CT indices of emphysema and airway disease that were adjusted for demographic and physiologic variables as well as brand of CT scanner, only the %LAA-950 remained significantly associated with exercise performance. Holding other covariates fixed, this model showed that a 10% increase of CT emphysema reduced the distance walked in six minutes 28.6 meters (95% Confidence Interval = −51.2, −6.0, p = 0.01). Conclusion These results suggest that the extent of emphysema but not airway disease measured by volumetric CT contributes independently to exercise limitation in subjects with COPD.

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Selection of Appropriate Computed Tomographic Image Reconstruction Algorithms for a Quantitative Multicenter Trial of Diffuse Lung Disease

Abstract: A moderately sharp reconstruction algorithm (Bone/B46f) was selected for the evaluation of diffuse lung disease.

Cited by 15 publications

References 10 publications

Correlation of Regional Emphysema and Lung Cancer: A Lung Tissue Research Consortium-Based Study

Correlation of Regional Emphysema and Lung Cancer: A Lung Tissue Research Consortium-Based Study

Optimal threshold in CT quantification of emphysema

Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD

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