Selection of cord blood unit(s) for transplantation

Wall, Donna A.; Chan, Ka Wah

doi:10.1038/bmt.2008.100

Cited by 38 publications

(15 citation statements)

References 54 publications

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“…25,26 This suggestion, however, is not supported by our analysis. We found no difference in the likelihood or speed of neutrophil A higher level of HLA match between the units was associated with engraftment of both units, and this finding was detected at both levels of resolution of HLA match.…”

Section: Discussioncontrasting

confidence: 97%

Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts

Avery¹,

Shi

Lubin³

et al. 2011

Blood

121

130

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The influence of cell dose and human leukocyte antigen (HLA) match on doubleunit cord blood (CB) engraftment is not established. Therefore, we analyzed the impact of cell dose and high-resolution HLA match on neutrophil engraftment in 84 double-unit CB transplant recipients. The 94% sustained engraftment rate was accounted for by 1 unit in nearly all patients. Higher CD3 ؉ cell doses (P ‫؍‬ .04) and percentage of CD34 ؉ cell viability (P ‫؍‬ .008) were associated with unit dominance. After myeloablative conditioning, higher dominant unit total nucleated cell (TNC), CD34 ؉ cell, and colony-forming unit doses were associated with higher sustained engraftment and faster neutrophil recovery (P ‫؍‬ .07, P ‫؍‬ .0008, and P < .0001, respectively). Total infused TNC (P ‫؍‬ .0007) and CD3 ؉ cell doses (P ‫؍‬ .001) also significantly influenced engraftment. At high-resolution extensive donor-recipient HLA disparity was frequent, but had no influence on engraftment (P ‫؍‬ .66), or unit dominance (P ‫؍‬ .13). Although the unit-unit HLA match also did not affect sustained engraftment (P ‫؍‬ 1.0), recipients of units closely (7-10 to 10-10) HLA-matched to each other were more likely to demonstrate initial engraftment of both units (P < .0001). Our findings have important implications for unit selection and provide further insight into double-unit biology. (Blood. 2011;117(12): 3277-3285)

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Section: Discussioncontrasting

confidence: 97%

Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts

Avery¹,

Shi

Lubin³

et al. 2011

Blood

121

130

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Recently several reviews including the clinical results of adult CBT have been published. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] In this review, we focus on recent results of myeloablative CBT in adults.…”

Section: Introductionmentioning

confidence: 99%

Cord blood transplantation in adults

Ooi

2009

Bone Marrow Transplant

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Umbilical cord blood has several advantages of immediate availability, no risk to donors, a lower risk for acute and chronic GVHD despite major human leukocyte Ag (HLA) disparity, and a lower risk of transmitting infections. As a result of the early successes with pediatric cord blood transplantation (CBT), cord blood from unrelated donors have been increasingly used as an alternative stem cell source for adult patients with hematological malignancies. Recent single-institute and registry-based studies suggest that CBT is a safe, feasible and effective strategy for adult patients without suitable related or unrelated BM donors. In this review, we focus on recent results of myeloablative CBT in adults.

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“…Thus, it is now a major goal of public cord blood banking to provide a large and diverse inventory of HLA typing to extend transplant access to racial and ethnic minorities. 9,10 For transplant programs in countries in which no national BM registries or cord blood banks are established, the only available option is to search for suitable donors or UCB transplantation units in foreign registries and banks, but the diversity of the genetic background in different ethnicities around the world may diminish the probabilities of finding suitable matches. Thus, many such countries are now supporting the establishment of national cord blood banks to enhance the probability of finding suitable units for their nationals who need SCT but have no suitable matched family donor.…”

Section: Introductionmentioning

confidence: 99%

Unrelated cord blood transplantation in pediatric patients: a report from Saudi Arabia

Ayas

Al-Seraihi

Al‐Jefri

et al. 2009

Bone Marrow Transplant

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In unrelated cord blood (UCB) transplantation, survival has been shown to correlate with the degree of HLA matching. Thus, to extend transplant access to different ethnic backgrounds, many western UCB transplantation banks now encourage donation from non-Caucasians. Until recently, Saudi Arabia did not have a national UCB bank. In this study we report our experience in UCB transplantation in children using units procured from western cord blood banks. A total of 97 children underwent unrelated UCB transplantation at King Faisal Specialist Hospital and Research Center (KFSHRC), of which 95 were of Arab ethnicity. A total of 30 patients had malignant disorders, 25 patients had non-malignant hematological disorders and 42 patients had inborn errors. Conditioning was according to disease, with six patients receiving reduced-intensity regimens. In all, 46 patients received one-Ag-mismatched units and 51 received twoAg-mismatched units. Engraftment occurred in 93% of patients, the 100-TRM was 15%, acute GVHD developed in 20% of patients and chronic GVHD occurred in 9% of patients. The 5-year OS and EFS estimates were 52 and 43%, respectively. The search for UCB transplantation units for Saudi patients in western banks yielded reasonably compatible units for our patients; the results are consistent with published data. Our data are encouraging for UCB transplant programs in countries in which there are no national UCB transplantation banks.

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Selection of cord blood unit(s) for transplantation

Cited by 38 publications

References 54 publications

Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts

Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts

Cord blood transplantation in adults

Unrelated cord blood transplantation in pediatric patients: a report from Saudi Arabia

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