Selection of DNA aptamers for breast cancer

Zamay, Galina S.; Belyanina, Irina V.; Zamay, Anna S.; Комарова, М. А.; Krat, Alexey V.; Еремина, Е. Н.; Зуков, Р. А.; Соколов, А. Е.; Zamay, Tatiana N.

doi:10.1134/s1990750816020128

Cited by 3 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functionally, aptamers are analogues of antibodies, but in many respects, aptamers are superior. They are selected through an in vitro evolution process in a few days, without prior knowledge of the cell-specific biomarkers to live cells, tissues, viruses, bacteria, proteins, and small molecules [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. The resulting aptamers are chemically synthesized with simple chemical procedures in high purity and at low cost; therefore, they are considered to be synthetic chemical products, rather than biological.…”

Section: Aptamersmentioning

confidence: 99%

Targeted Magnetic Nanotheranostics of Cancer

et al. 2017

View full text Add to dashboard Cite

Current advances in targeted magnetic nanotheranostics are summarized in this review. Unique structural, optical, electronic and thermal properties of magnetic materials in nanometer scale are attractive in the field of biomedicine. Magnetic nanoparticles functionalized with therapeutic molecules, ligands for targeted delivery, fluorescent and other chemical agents can be used for cancer diagnostic and therapeutic purposes. High selectivity, small size, and low immunogenicity of synthetic nucleic acid aptamers make them attractive delivery agents for therapeutic purposes. Properties, production and functionalization of magnetic nanoparticles and aptamers as ligands for targeted delivery are discussed herein. In recent years, magnetic nanoparticles have been widely used in diagnostic methods, such as scintigraphy, single photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI), and Raman spectroscopy. Therapeutic purposes of magnetic nanoconstructions are also promising. They are used for effective drug delivery, magnetic mediated hypertermia, and megnetodynamic triggering of apoptosis. Thus, magnetic nanotheranostics opens a new venue for complex differential diagnostics, and therapy of metastatic cancer.

show abstract