Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?

Biliński, S; Kloc, Małgorzata; Tworzydło, Wacław

doi:10.1007/s10815-017-1006-3

Cited by 48 publications

(50 citation statements)

References 61 publications

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“…A more widely conserved function of the Bb is mitochondrial selection, which are therefore highly represented in the Bb (Bilinski et al, 2017). In Xenopus, they are embedded in a matrix formed by Xvelo (Boke et al, 2016).…”

Section: Tdrd6a Is Essential For Bb and Gp Integritymentioning

confidence: 99%

Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification

Roovers

Kaaij

Redl

et al. 2018

Preprint

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In recent years, it has become clear that phase separation represents an important class of subcellular compartmentalization. However, relatively little is known about how the formation or disassembly of such compartments is regulated. In zebrafish, the Balbiani body (Bb) and the germ plasm (Gp) are phase-separated structures essential for germ cell specification and home to many germ cell-specific mRNAs and proteins. Throughout development, these structures range from a single large aggregate (Bb), to a dispersed state and back to relatively large assemblies (Gp). Formation of the Bb requires Bucky ball (Buc), a protein with prion-like properties. We found that the multi-tudor domain-containing protein Tdrd6a interacts directly with Buc, affecting its mobility and aggregation properties. Importantly, lack of this regulatory interaction leads to significant defects in germ cell development. Our work presents a new mechanism for how prion-like protein-aggregations can be regulated and highlights the biological relevance of such regulatory events.

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Section: Tdrd6a Is Essential For Bb and Gp Integritymentioning

confidence: 99%

Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification

Roovers

Kaaij

Redl

et al. 2018

Preprint

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“…In many cases, the cystoblasts continue mitotic division (karyokineses), however, cytokinesis is not complete, and the female germline cysts composed of cystocytes are formed. In the ovaries of teleost fish, and also of other vertebrates and of invertebrates, some cystocytes are eliminated by cell death, the remaining begin meiosis and continue the development as the oocytes (Bilinski, Kloc, & Tworzydlo, ; Elkouby, ; Elkouby, Jamieson‐Lucy, & Mullins, ; Elkouby & Mullins, ; Ikami, Nuzhat, & Lei, ; Kloc, Bilinski, Dougherty, Brey, & Etkin, ; Lei & Spradling, ; Marlow & Mullins, ; Mazzoni, Grier, & Quagio‐Grassiotto, ; Nakamura et al, ; Żelazowska & Fopp‐Bayat, ). The karyokineses of cystoblasts that lead to the formation of cysts are sometimes stopped in the ovaries and the cystoblasts enter meiosis without producing the cysts (Grier, Porak, Carroll, & Parenti, ).…”

Section: Introductionmentioning

confidence: 99%

“…remaining begin meiosis and continue the development as the oocytes (Bilinski, Kloc, & Tworzydlo, 2017;Elkouby, 2017;Elkouby, Jamieson-Lucy, & Mullins, 2016;Elkouby & Mullins, 2017;Ikami, Nuzhat, & Lei, 2017;Kloc, Bilinski, Dougherty, Brey, & Etkin, 2004;Lei & Spradling, 2016;Marlow & Mullins, 2008;Mazzoni, Grier, & Quagio-Grassiotto, 2010;Nakamura et al, 2011;Żelazowska & Fopp-Bayat, 2017b). The karyokineses of cystoblasts that lead to the formation of cysts are sometimes stopped in the ovaries and the cystoblasts enter meiosis without producing the cysts (Grier, Porak, Carroll, & Parenti, 2018).…”

mentioning

confidence: 99%

“…In this species, the cells covering the surface of the oocyte at its vegetal pole differ from all other FCs and are engaged in the formation of attaching filaments in the eggshell (Iwamatsu & Nakashima, 1996). It participates also in the elimination of the dysfunctional mitochondria from the oocytes (Bilinski, Kloc, & Tworzydlo, 2017). The Balbiani body always assembles around a pair of centrioles (the centrosome; Kloc et al, 2004Kloc et al, , 2008Kloc et al, , 2014.…”

mentioning

confidence: 99%

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Previtellogenic oocytes of South African largemouth bass Micropterus salmoides Lacépède 1802 (Actinopterygii, Perciformes) ‐ the Balbiani body, cortical alveoli and developing eggshell

Żelazowska

Halajian

2019

Journal of Morphology

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The ovaries of the largemouth bass Micropterus salmoides, an alien and invasive species in South Africa, contain a germinal epithelium which consists of germline and somatic cells, as well as previtellogenic and late vitellogenic ovarian follicles. The ovarian follicle consists of an oocyte surrounded by follicular cells and a basal lamina; thecal cells adjacent to this lamina are covered by an extracellular matrix. In this article, we describe the Balbiani body and the polarization and ultrastructure of the cytoplasm (ooplasm) in previtellogenic oocytes. The nucleoplasm in all examined oocytes contains lampbrush chromosomes, nuclear bodies and several nucleoli near the nuclear envelope. The ultrastructure of the nucleoli is described. Numerous nuage aggregations are present in the perinuclear cytoplasm in germline cells as well as in the ooplasm. Possible roles of these aggregations are discussed. The ooplasm contains the Balbiani body, which defines the future vegetal region in early previtellogenic oocytes. It is comprised of nuage aggregations, rough endoplasmic reticulum, Golgi apparatus, mitochondria, complexes of mitochondria with nuage‐like material, and lysosome‐like organelles. In mid‐previtellogenic oocytes, the Balbiani body surrounds the nucleus and later disperses in the ooplasm. The lysosome‐like organelles fuse and transform into vesicles containing material which is highly electron dense. As a result of the fusion of the vesicles of Golgi and rough endoplasmic reticulum, the cortical alveoli arise and distribute uniformly throughout the ooplasm of late previtellogenic oocytes. During this stage, the deposition of the eggshell (zona radiata) begins. The eggshell is penetrated by canals containing microvilli and consists of the following: the internal and the external egg envelope. In the external envelope three sublayers can be distinguished.

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“…Alternatively, it has been proposed that the purifying filter is based on the existence of a subpopulation of mtDNAs or mitochondria that is tagged for replication or inheritance by PGCs (Wai et al, 2008;Hill et al, 2014;Ma et al, 2014;Kang et al, 2016;Wolf et al, 2017). In several species, oocytes harbor a perinuclear structure called the mitochondrial cloud or Balbiani body that supports the existence of such mechanism (Cox and Spradling, 2003;Pepling et al, 2007;Zhang et al, 2008;Lei and Spradling, 2016;Bilinski et al, 2017). This structure is comprised of mitochondria and determinants of future germ cells, which tags the organelles to be inherited by the germline.…”

Section: Mitochondrial Inheritancementioning

confidence: 99%

The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases

Chiaratti

Garcia

Carvalho

et al. 2018

Cell Biology International

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Mitochondria play a fundamental role during development of the female germline. They are fragmented, round, and small. Despite these characteristics suggesting that they are inactive, there is accumulating evidence that mitochondrial dysfunctions are a major cause of infertility and generation of aneuploidies in humans. In addition, mitochondria and their own genomes (mitochondrial DNA-mtDNA) may become damaged with time, which might be one reason why aging leads to infertility. As a result, mitochondria have been proposed as an important target for evaluating oocyte and embryo quality, and developing treatments for female infertility. On the other hand, mutations in mtDNA may cause mitochondrial dysfunctions, leading to severe diseases that affect 1 in 4,300 people. Moreover, very low levels of mutated mtDNA seem to be present in every person worldwide. These may increase with time and associate with late-onset degenerative diseases such as Parkinson disease, Alzheimer disease, and common cancers. Mutations in mtDNA are transmitted down the maternal lineage, following a poorly understood pattern of inheritance. Recent findings have indicated existence in the female germline of a purifying filter against deleterious mtDNA variants. Although the underlying mechanism of this filter is largely unknown, it has been suggested to rely on autophagic degradation of dysfunctional mitochondria or selective replication/transmission of non-deleterious variants. Thus, understanding the mechanisms regulating mitochondrial inheritance is important both to improve diagnosis and develop therapeutic tools for preventing transmission of mtDNA-encoded diseases.

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Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?

Cited by 48 publications

References 61 publications

Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification

Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification

Previtellogenic oocytes of South African largemouth bass Micropterus salmoides Lacépède 1802 (Actinopterygii, Perciformes) ‐ the Balbiani body, cortical alveoli and developing eggshell

The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases

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