Selection of Patient for Cardiac Resynchronization Therapy: Role of QT Corrected Dispersion

Timineri, Salvatore; Mulè, Massimiliano; Puzzangara, Euglena; Santangelo, Gloria; Dugo, Daniela; Schillaci, Vincenzo; Grazia, Angelo Di; Liotta, Caudio; Scandura, Salvatore; Tempio, Donatella; Tamburino, Corrado; Calvi, Valéria

doi:10.1111/j.1540-8159.2012.03402.x

Pacing Clinical Electrophis

2012

DOI: 10.1111/j.1540-8159.2012.03402.x

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Selection of Patient for Cardiac Resynchronization Therapy: Role of QT Corrected Dispersion

Salvatore Timineri

Massimiliano Mulè

Euglena Puzzangara

et al.

Abstract: This study suggests that QTc dispersion in addition to QRS duration could improve the sensitivity of electrocardiogram in a patient's selection for CRT.

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“…Electrocardiography parameters, especially QRS duration is very important to patient selection for CRT implantation6. Besides, other parameters reflecting the abnormal ventricular repolarization potentially predict CRT non-response7, e.g. QT interval, TpTe, and J wave, etc.…”

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Electro-echocardiographic Indices to Predict Cardiac Resynchronization Therapy Non-response on Non-ischemic Cardiomyopathy

Chen

Han

et al. 2017

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Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a retrospective study to review a total of 227 patients of dyssynchronous heart failure underwent CRT implantation. Logistic analysis was performed between CRT responders and CRT non-responders. The primary outcome was the occurrence of improved left ventricular ejection fraction 1 year after CRT implantation. We concluded that LVEDV > 255 mL (OR = 2.236; 95% CI, 1.016–4.923) rather than LVESV > 160 mL (OR = 1.18; 95% CI, 0.544–2.56) and TpTe/QTc > 0.203 (OR = 5.206; 95% CI, 1.89–14.34) significantly predicted CRT non-response. Oppositely, S wave > 5.7 cm/s (OR = 0.242; 95% CI, 0.089–0.657), E/A > 1 (OR = 0.211; 95% CI, 0.079–0.566), E’/A’ > 1 (OR = 0.054; 95% CI, 0.017–0.172), CLBBB (OR = 0.141; 95% CI, 0.048–0.409), and QRS duration >160 ms (OR = 0.52; 95% CI, 0.305–0.922) surprisingly predicted low-probability of CRT non-response.

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mentioning

confidence: 99%

Electro-echocardiographic Indices to Predict Cardiac Resynchronization Therapy Non-response on Non-ischemic Cardiomyopathy

Chen

Han

et al. 2017

Sci Rep

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Selection of Patient for Cardiac Resynchronization Therapy: Role of QT Corrected Dispersion

Abstract: This study suggests that QTc dispersion in addition to QRS duration could improve the sensitivity of electrocardiogram in a patient's selection for CRT.

Cited by 1 publication

References 37 publications

Electro-echocardiographic Indices to Predict Cardiac Resynchronization Therapy Non-response on Non-ischemic Cardiomyopathy

Electro-echocardiographic Indices to Predict Cardiac Resynchronization Therapy Non-response on Non-ischemic Cardiomyopathy

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