Selection of Patients for Re-Irradiation with Local Implants in Carcinomas of Oropharynx and Tongue

Langlois, Denis; Hoffstetter, S.; Pernot, M.

doi:10.3109/02841868809093590

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…These studies consisted of conventional and/or hyperfractionated courses of 50-65 Gy. 18,19 Some series yielded 5-year locoregional control rates up to 50%-70%. [15][16][17] Late toxicity consisted of mostly neck fibrosis, soft tissue necrosis, and osteoradionecrosis.…”

Section: Historical Series Of Reirradiation Without Chemotherapymentioning

confidence: 99%

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Reirradiation of head and neck cancer using modern highly conformal techniques

Phan

2018

Head & Neck

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Locoregional disease recurrence or development of a second primary cancer after definitive radiotherapy for head and neck cancers remains a treatment challenge. Reirradiation utilizing traditional techniques has been limited by concern for serious toxicity. With the advent of newer, more precise radiotherapy techniques, such as intensity-modulated radiotherapy (IMRT), proton radiotherapy, and stereotactic body radiotherapy (SBRT), there has been renewed interest in curative-intent head and neck reirradiation. However, as most studies were retrospective, single-institutional experiences, the optimal modality is not clear. We provide a comprehensive review of the outcomes of relevant studies using these 3 head and neck reirradiation techniques, followed by an analysis and comparison of the toxicity, tumor control, concurrent systemic therapy, and prognostic factors. Overall, there is evidence that IMRT, proton therapy, and SBRT reirradiation are feasible treatment options that offer a chance for durable local control and survival. Prospective studies, particularly randomized trials, are needed.

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Section: Historical Series Of Reirradiation Without Chemotherapymentioning

confidence: 99%

“…Local control and survival rates varied considerably, from 0%-70%. 18,19 Some series yielded 5-year locoregional control rates up to 50%-70%. 18,20,21 In 1 series of patients treated for regional neck recurrences with brachytherapy, almost 75% died of uncontrolled neck disease.…”

Section: Historical Series Of Reirradiation Without Chemotherapymentioning

confidence: 99%

Reirradiation of head and neck cancer using modern highly conformal techniques

Phan

2018

Head & Neck

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“…In several institutions the low-dose-rate brachytherapy technique is performed, and doses and results of different brachytherapy systems are simply not comparable (Dutreix, 1988). In addition, results in patients suffering from tongue-base recurrence are usually worse than in patients suffering from recurrence in the mobile tongue or the faucial arch (Mazeron et al, 1987;Langlois et al, 1988). Therefore, our results show that recurrent cancer of the tongue-base is an indication for afterloading brachytherapy, too.…”

Section: Figmentioning

confidence: 76%

“…Therefore, our results show that recurrent cancer of the tongue-base is an indication for afterloading brachytherapy, too. So we cannot follow Langlois et al who do not recommend brachytherapy on this specific indication (Langlois et al, 1988). In the future, results of brachytherapy may be improved by simultaneous interstitial hyperthermia (Seegenschmidt et al, 1992), but up to now this technique has been available at a few centres only.…”

Section: Figmentioning

confidence: 93%

Endoscopic ultrasound-guided brachytherapy of head and neck tumours. A new procedure for controlled application

Maier

Henne²,

Krebs

et al. 1999

J. Laryngol. Otol.

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Brachytherapy is an established procedure in primary and in recurrent cancer. We perform afterloading brachytherapy during general anaesthesia. The target organ is punctured with hollow needles which are loaded with 192iridium via remote control. The depth and number of needles depend on tumour extension. In the interdisciplinary approach of our departments, this method has been improved and supplied by B-scan ultrasound control. Needles are positioned under continuous ultrasonographic guidance, and adjacent structures (e.g. the carotid artery) are localized ultrasonographically. Thus violation of the large vessels is avoided and the exact position of the needles within the tumour is improved.In this paper, we report results on 22 patients suffering from recurrent carcinoma of the head and neck following surgery and curative radiation, and 17 patients with first onset of cancer. We did not observe any severe complications such as haemorrhage, osteomyelitis, or dyspnoea. The only side-effect was temporary oedema, sometimes associated with a short-term increase of pain. No systemic side-effects occurred.The method is described and results from both patient groups are reported in detail. We conclude from our data that ultrasonographically-controlled endoscopic brachytherapy is a valuable procedure in locally-advanced primary, and in recurrent head and neck cancer.

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