Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation

Smink, Alexandra M.; Haan, Bart J. de; Paredes-Juarez, Genaro A.; Wolters, Anouk H. G.; Kuipers, Jeroen; Giepmans, Ben N. G.; Schwab, Leendert W.; Engelse, Marten A.; Apeldoorn, Aart van; Koning, Eelco J.P. de; Faas, Marijke M.; Vos, Paul de

doi:10.1088/1748-6041/11/3/035006

Cited by 30 publications

(19 citation statements)

References 56 publications

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“…Some of the problems associated with non‐highly vascularized sites, e.g., poor oxygen supply, are currently being addressed with the use of scaffolds and extracellular matrix support to the islets, with promising results .…”

Section: Immune Reactions Toward Pancreatic Islet Grafts In Human Andmentioning

confidence: 99%

Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human

et al. 2019

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These authors equally contributed to the work. SUMMARYPancreatic islet allotransplantation is a treatment for patients with severe forms of type 1 diabetes. As long-term graft function and survival are not yet optimal, additional studies are warranted in order to continue improving transplant outcomes. The mechanisms of islet graft loss and tolerance induction are often studied in murine diabetes models. Despite numerous islet transplantation studies successfully performed over recent years, translation from experimental mouse models to human clinical application remains elusive. This review aims at critically discussing the strengths and limitations of current mouse models of diabetes and experimental islet transplantation. In particular, we will analyze the causes leading to diabetes and compare the immunological mechanisms responsible for rejection between mouse and human. A better understanding of the experimental mouse models should facilitate translation to human clinical application. Transplant International 2019; 32: 903-912

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Section: Immune Reactions Toward Pancreatic Islet Grafts In Human Andmentioning

confidence: 99%

Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human

et al. 2019

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“…Pancreatic islet isolation at LUMC was performed as previously described [13]. Human donor islets were used if deemed unsuitable for CIT and if research consent was present according to national laws and regulations.…”

Section: Human Islet Retrievalmentioning

confidence: 99%

“…Indeed, the biomaterial used for manufacturing an islet encapsulation device requires careful selection [13]. The device itself should be suitable for handling during surgery, which means it should be compliant and resistant to breakage.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress in alpha and beta cells as a selection criterion for biocompatible biomaterials

Sthijns

Jetten

Mohammed

et al. 2019

Preprint

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The clinical success of islet transplantation is limited by factors including acute ischemia, stress upon transplantation, and delayed vascularization. Islets experience high levels of oxidative stress due to delayed vascularization after transplantation and this can be further aggravated by their encapsulation and undesirable cell-biomaterial interactions. To identify biomaterials that would not further increase oxidative stress levels and that are also suitable for manufacturing a beta cell encapsulation device, we studied five clinically approved polymers for their effect on oxidative stress and islet (alpha and beta cell) function. We found that 300 poly(ethylene oxide terephthalate) 55/poly(butylene terephthalate) 45 (PEOT/PBT300) was more resistant to breakage and more elastic than other biomaterials, which is important for its immunoprotective function. In addition, PEOT/PBT300 did not induce oxidative stress or reduce viability in MIN6 beta cells, and even promoted protective endogenous antioxidant expression over 7 days. Importantly, PEOT/PBT300 is one of the biomaterials we studied that did not interfere with insulin secretion in human islets. These data indicate that PEOT/PBT300 may be a suitable biomaterial for an islet encapsulation device. PEOT/PBT4000

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“…Also, current research is conducted on three different types of polymers, but only to evaluate the viability of seeded human islets (Table 1) [21]. The impact of the shape is unknown.…”

Section: The Role Of Scaffoldmentioning

confidence: 99%

Use of 3D bioprinting in biomedical engineering for clinical application

Karzyński¹,

Kosowska²,

Ambrożkiewicz³

et al. 2018

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Tissue engineering is a widely developing scientific field, which combines technological solutions with the biology of the living organism. Regenerative medicine that uses tools of tissue engineering offers alternative means of therapy enhancing damaged tissues or organs. One of the development directions of contemporary chemical engineering is the scientific description of novel technologies that will enable production of porous structures -with high utility for biomedical engineering. 3D printing is one of the most popular methods used to produce scaffolds for cell culture. Nowadays a research team, in which authors are currently working, is dealing with the problem of manufacturing 3D constructs that play the role of artificial organ, obtained via 3D bioprinting. In the current article we present the possibilities and limitations of 3D bioprinting method in the context of possible application of manufactured structures as fully functional organs. StreszczenieInżynieria tkankowa stanowi dynamicznie rozwijającą się dziedzinę nauki łączącą rozwiązania techniki z biologią żywe-go organizmu. Medycyna regeneracyjna, korzystając z narzędzi inżynierii tkankowej, oferuje alternatywne podejście do terapii wspomagających odbudowę zniszczonych tkanek czy narządów. Jednym z kierunków rozwoju współczesnej inży-nierii chemicznej jest opracowanie nowoczesnych technologii umożliwiających wywarzanie struktur porowatych o wysokiej użyteczności w inżynierii biomedycznej. Wśród najbardziej popularnych metod wykorzystywanych do wytwarzania rusztowań do hodowli komórek jest technika druku 3D. Obecnie zespół badawczy, w którym pracują autorzy, opracowuje technikę wytwarzania za pomocą biodruku 3D konstruktów spełniających funkcję sztucznych narządów. W artykule przedstawiono zestawienie możliwości i ograniczeń omawianej metody biodruku 3D w kontekście możliwości zastosowania wytworzonych struktur jako funkcjonalnych sztucznych organów.

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Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation

Cited by 30 publications

References 56 publications

Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human

Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human

Oxidative stress in alpha and beta cells as a selection criterion for biocompatible biomaterials

Use of 3D bioprinting in biomedical engineering for clinical application

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