The American Journal of Cardiology

1985

DOI: 10.1016/0002-9149(85)90491-6

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Selective absorption of ultraviolet laser energy by human atherosclerotic plaque treated with tetracycline

Douglas Murphy-Chutorian

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Fluorescence Spectral Analysis Of Arteriosclerotic Lesions U1

Mechanism Of Doxycycline Accumulation In Arteriosclerotic Le1

Accumulation Of Porfimer Sodium In Atheroma1

Introduction1

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1986

1986

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Cited by 69 publications

(12 citation statements)

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“…19 In the present study, because the yellow-green DOXY specific fluorescence was seen in specimens obtained from DCA, this is the first time that the accumulation of DOXY in coronary atheroma has been confirmed clinically. Watari et al reported that they measured HpD fluorescence in the aortae of arteriosclerotic rabbits in vitro and in vivo, and that it is possible to estimate from its intensity the degree of intimal hypertrophy.…”

Section: Fluorescence Spectral Analysis Of Arteriosclerotic Lesions Usupporting

confidence: 52%

“…19 In the present study, DOXY was accumulated in coronary atheroma 4 h postadministration, but further study is needed to determine the optimum time after administration.…”

Section: Mechanism Of Doxycycline Accumulation In Arteriosclerotic Lementioning

confidence: 79%

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Fluorescence Spectrum Analysis of Atherosclerotic Plaque Using Doxycycline

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arious interventional therapies are presently used in the treatment of ischemic heart disease. In clinical trials in the US, percutaneous transluminal laser coronary angioplasty (PTLCA) was performed on 3,000 patients and 3,592 lesions using excimer laser, with a reported success rate of 84%. 1 When this method is compared with percutaneous transluminal coronary angioplasty (PTCA) using a balloon, PTLCA can be performed on diffuse lesions in which PTCA is difficult, and it may be possible to use the laser to recanalize a chronic total occlusion, a lesion in which the passage of a guide wire would be very difficult. In addition, PTCA is contraindicated in ostial stenosis, and PTLCA is considered the first choice in closed chest treatment. In PTLCA, however, unexpected coronary perforation occurs in between 1.2 to 2.4% of cases, 1-4 a rate which is obviously higher than for PTCA. As avoidance of coronary perforation is the paramount consideration in PTLCA, the requirement is for an appropriate guidance system to show the condition of the hypertrophic intima and the degree of ablation in real time, so that the atheroma alone is selectively ablated and the tunica media not irradiated.At present, evaluation of coronary arteriosclerotic lesions is made using angioscopy and intravascular ultrasound, neither of which can be inserted into the coronary artery at the same time as the laser irradiation system and so cannot be the appropriate guidance system. Fluorescence spectrum analysis is a method by which the fluorescence induced by irradiation at specific wavelengths of an arteriosclerotic lesion is examined in detail to make the diagno-

“…19 In the present study, because the yellow-green DOXY specific fluorescence was seen in specimens obtained from DCA, this is the first time that the accumulation of DOXY in coronary atheroma has been confirmed clinically. Watari et al reported that they measured HpD fluorescence in the aortae of arteriosclerotic rabbits in vitro and in vivo, and that it is possible to estimate from its intensity the degree of intimal hypertrophy.…”

Section: Fluorescence Spectral Analysis Of Arteriosclerotic Lesions Usupporting

confidence: 52%

“…19 In the present study, DOXY was accumulated in coronary atheroma 4 h postadministration, but further study is needed to determine the optimum time after administration.…”

Section: Mechanism Of Doxycycline Accumulation In Arteriosclerotic Lementioning

confidence: 79%

Fluorescence Spectrum Analysis of Atherosclerotic Plaque Using Doxycycline

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,

²

,

³

et al. 1999

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arious interventional therapies are presently used in the treatment of ischemic heart disease. In clinical trials in the US, percutaneous transluminal laser coronary angioplasty (PTLCA) was performed on 3,000 patients and 3,592 lesions using excimer laser, with a reported success rate of 84%. 1 When this method is compared with percutaneous transluminal coronary angioplasty (PTCA) using a balloon, PTLCA can be performed on diffuse lesions in which PTCA is difficult, and it may be possible to use the laser to recanalize a chronic total occlusion, a lesion in which the passage of a guide wire would be very difficult. In addition, PTCA is contraindicated in ostial stenosis, and PTLCA is considered the first choice in closed chest treatment. In PTLCA, however, unexpected coronary perforation occurs in between 1.2 to 2.4% of cases, 1-4 a rate which is obviously higher than for PTCA. As avoidance of coronary perforation is the paramount consideration in PTLCA, the requirement is for an appropriate guidance system to show the condition of the hypertrophic intima and the degree of ablation in real time, so that the atheroma alone is selectively ablated and the tunica media not irradiated.At present, evaluation of coronary arteriosclerotic lesions is made using angioscopy and intravascular ultrasound, neither of which can be inserted into the coronary artery at the same time as the laser irradiation system and so cannot be the appropriate guidance system. Fluorescence spectrum analysis is a method by which the fluorescence induced by irradiation at specific wavelengths of an arteriosclerotic lesion is examined in detail to make the diagno-

“…[24][25][26] The pattern of accumulation of HpD in atherosclerotic tissue has been reported to show the greatest red fluorescence in the lumenal side of the intima, then gradually decrease towards the media, with no medial accumulation. 8,9 The mechanisms of HpD accumulation in atherosclerotic tissue include: (1) porphyrin accumulates in response to rapidly proliferating tissues such as malignancies; (2) vascular endothelial permeability is increased in atherosclerotic areas; (3) porphyrin possesses affinity for fibrinogen and platelets; and (4) porphyrin bound to lipoproteins is phagocytosed by macrophages.…”

Section: Accumulation Of Porfimer Sodium In Atheromamentioning

confidence: 99%

Photodynamic Therapy of Atherosclerosis Using YAG-OPO Laser and Porfimer Sodium, and Comparison With Using Argon-Dye Laser

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We performed photodynamic therapy (PDT) using the Yttrium Aluminium Garnet-Optical Parametric Oscillated (YAG-OPO) laser in cases of atherosclerosis, and examined its efficacy in vivo. We also performed PDT using an Argon-dye (Ar-dye) laser with the same output, and compared the efficacies. Following balloon denudation injury of the thoracoabdominal aorta, rabbits were raised on a cholesterol diet for 16 weeks, producing atheroma in that region. At 24 h following the administration of Photofrin 5 mg/kg, PDT was performed, and animals were sacrificed at 1 day, 1 week, and 2 weeks following the procedure to examine its efficacy. This was compared with the efficacy of PDT using the Ar-dye laser. Following PDT using a YAG-OPO laser, an increase in the vessel lumen was seen due to reduction of the hypertrophic intima and media, without the appearance of inflammatory cells. This result was seen more strongly in PDT using the pulse wave YAG-OPO laser than with the continuous wave Ar-dye laser, affecting not just the intima but also the media. These data demonstrated that PDT can effectively regress atherosclerotic lesions. (Jpn Circ J 1999; 63: 288 -295)

“…Fluorescence compounds known to localize in atherosclerotic plaque include hematoporphrin derivative (HpD)[fl , tetracyclin [2], chlortetracycline (CTC-HCI) [3] and other new compounds which are under further investigation. Different modes of porphyrin accumulation plaques have been suggested.…”

Section: Introductionmentioning

confidence: 99%

Tissue discrimination by laser-induced fluorescence method

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SPIE Proceedings

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On the basis of the differentiation of molecular structures between healthy and diseased tissue, spectroscopic information could be used for tissue discrimination. The experimental results on laser induced fluorescence of atherosclerotic deposits through the new exogenous photosensitizer Hypocrellin A (HA) was reported and algorithms implemented to on the arterial fluorescence spectra has been developed to be capable of discriminating normal from atherosclerotic tissue in this paper, indicating that Hypocrellin (HA) could be used as a clinical probe for both atherosclerotic lesions. Better discriminatory effect was found on fatty and calcified tissue.

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