Selective action of a CCK‐B/gastrin receptor antagonist, S‐0509, on pentagastrin‐, peptone meal‐ and beer‐stimulated gastric acid secretion in dogs

Sasaki, Nobuo; Matsuno, Kuniharu; Okabe, Susumu

doi:10.1046/j.1365-2036.2000.00732.x

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…As reported in our previous study, 18 15 min after separate administrations of peptone meal and beer, the plasma gastrin levels were approximately 200 pg/mL and 230 pg/mL, respectively. Fifteen minutes following the combined treatment with peptone and beer, the plasma gastrin level significantly increased by nearly 4‐fold compared with the basal level, demonstrating that this combination of stimulants resulted in an additive effect on the plasma gastrin level.…”

Section: Discussionsupporting

confidence: 84%

Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal – the role of endogenous gastrin

Matsuno

Sasaki

Okabe

2000

Aliment Pharmacol Ther

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Aim: To examine the effects of beer, ethanol, peptone meal and combinations of either peptone meal and beer or peptone meal and ethanol on gastric acid secretion in vagally denervated pouch dogs. Methods and Results: The oral administration of either 200 mL of beer, 5% ethanol or 10% peptone meal signi®cantly stimulated gastric acid secretion for 60± 90 min in these dogs. With 5% ethanol the plasma gastrin concentration was not affected for 90 min. Combinations of 10% peptone and beer (peptone±beer) or 10% peptone and 5% ethanol (peptone±ethanol) potentiated the acid secretion and increased the plasma gastrin level. While a selective cholecystokinin-B/gastrin receptor antagonist, S-0509, had no effect on ethanolstimulated acid secretion, the compound markedly inhibited both peptone±beer-stimulated and peptone± ethanol-stimulated gastric acid secretion. Famotidine and atropine signi®cantly inhibited gastric acid secretion stimulated by 5% ethanol, peptone±beer and peptone± ethanol. Conclusions: The mechanisms by which peptone±beer and peptone±ethanol stimulate gastric acid secretion may be mediated not only by increased plasma gastrin, but also by the action of histamine and acetylcholine coupled with the increased plasma gastrin. Ethanolstimulated secretion appears to be unrelated to circulating gastrin, yet may be related to the acid regulatory mechanism involving histamine and acetylcholine.

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Section: Discussionsupporting

confidence: 84%

Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal – the role of endogenous gastrin

Matsuno

Sasaki

Okabe

2000

Aliment Pharmacol Ther

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“…Indeed, we have already reported that S-0509 significantly inhibits gastric acid secretion induced by beer in Heidenhain pouch dogs. 11,12 Nonetheless, in the present study, S-0509 as well as atropine had little or no effect on wine-stimulated acid secretion in IBMX-pretreated glands. It is of interest that only famotidine significantly inhibited the wine-stimulated gastric acid secretion.…”

Section: Discussioncontrasting

confidence: 65%

“…Until now, it has been thought that alcoholic beverage‐induced stimulation of gastric acid secretion is principally mediated by circulating gastrin. Indeed, we have already reported that S‐0509 significantly inhibits gastric acid secretion induced by beer in Heidenhain pouch dogs 11 , . 12 Nonetheless, in the present study, S‐0509 as well as atropine had little or no effect on wine‐stimulated acid secretion in IBMX‐pretreated glands.…”

Section: Discussionmentioning

confidence: 91%

“…[7][8][9][10] It has been found that circulating gastrin levels are regularly increased after beer or wine administration and that a selective CCK-2 receptor antagonist inhibits beer-stimulated acid secretion in a dose-dependent manner in dogs. 11,12 Accordingly, an increase in gastrin level has been postulated to be the main driving force behind increased acid secretion. Against this, however, several compounds, including maleic acid and succinic acid, in fermented alcoholic beverages, have been found to stimulate gastric acid secretion without increasing gastrin levels.…”

Section: Introductionmentioning

confidence: 99%

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Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways

Matsuno¹,

Tomita²,

Okabe³

2002

Aliment Pharmacol Ther

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Background & aims: Alcoholic beverages such as beer and wine are well known to potently stimulate gastric acid secretion, most probably through an increase in circulating gastrin level. The present study examined whether or not wine stimulates gastric acid secretion by a direct effect on parietal cells, enterochromaffin‐like (ECL) cells or both. Methods: Gastric mucosa was isolated from female Japanese white rabbits and gland specimens were prepared by the collagenase digestion method. Acid secretion was assessed by gland accumulation of [14C] aminopyrine. The effects of red wine, ethanol, non‐alcoholic wine and drugs were determined by incubating gastric glands with aminopyrine. Radioactivity in solubilized glands was determined by a liquid scintillation counting. Results: Neither wine nor ethanol (diluted 1 : 102 to 1 : 104) had any effect on gastric acid secretion, whereas non‐alcoholic wine stimulated acid secretion in a dose‐dependent manner. All substances, however, significantly stimulated gastric acid secretion in IBMX (phosphodiesterase inhibitor)‐pretreated glands. S‐0509 (a CCK‐2 receptor antagonist) and atropine had no effect on acid secretion stimulated by wine, ethanol or non‐alcoholic wine in IBMX‐pretreated glands. Famotidine and omeprazole significantly inhibited the acid secretion resulting from all of the above stimulants. BAPTA (an intracellular Ca2+ chelator) inhibited acid secretion stimulated with wine or ethanol in a dose‐dependent manner, but did not inhibit secretion stimulated by non‐alcoholic wine. Conclusions: Wine was found to stimulate gastric acid secretion in gastric glands via two pathways, by an ethanol‐induced increase in the concentration of intracellular Ca2+ in parietal cells, and by histamine release from ECL cells potentially induced by constituents present in wine.

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“…The extract may act by blocking H 2 receptor and prevent histamine from binding, causing decreased in gastric acid secretion. It is established that inhibition of histamine release as a result of blockage of H 2 receptors, inhibit intracellular adenylate cyclase, Na + -K + ATPase and proton pump of parietal cells, thereby reduce the gastric acid secretion [39] , [40] .…”

Section: Discussionmentioning

confidence: 99%

Gastro-protective effect of methanol extract of Vernonia amygdalina (del.) leaf on aspirin-induced gastric ulcer in Wistar rats

et al. 2017

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Selective action of a CCK‐B/gastrin receptor antagonist, S‐0509, on pentagastrin‐, peptone meal‐ and beer‐stimulated gastric acid secretion in dogs

Abstract: S-0509 is a selective CCK-B/gastrin receptor antagonist in dogs that inhibits gastric acid secretion stimulated by pentagastrin and gastrin-releasing substances, but does not inhibit histamine-stimulated and carbachol-stimulated acid secretion.

Cited by 8 publications

References 28 publications

Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal – the role of endogenous gastrin

Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal – the role of endogenous gastrin

Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways

Gastro-protective effect of methanol extract of Vernonia amygdalina (del.) leaf on aspirin-induced gastric ulcer in Wistar rats

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