Selective advantage of HLA matching in successful uncomplicated oocyte donation pregnancies

Lashley, Lisa E.E.L.O.; Haasnoot, Geert W.; Spruyt-Gerritse, Marijke; Claas, Frans H.J.

doi:10.1016/j.jri.2015.05.006

Cited by 31 publications

(20 citation statements)

References 29 publications

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“…In has been suggested that human leukocyte antigen (HLA) matching of oocyte donors and their recipients may hinder the immunologic mismatch between mother and fetus, thus lowering the risk of placental pathology and HDP . This is supported by a recent finding of a significantly higher level of HLA matching between mother and child than would be expected by chance in successful, uncomplicated OD pregnancies with unrelated donors …”

Section: Discussionsupporting

confidence: 60%

Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta‐analysis

Storgaard

Loft

Bergh

et al. 2016

BJOG

140

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Section: Discussionsupporting

confidence: 60%

Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta‐analysis

Storgaard

Loft

Bergh

et al. 2016

BJOG

140

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“…, ; Lashley et al . ). The Hutterite results are in line with the hypothesis of mate selection disfavouring extreme MHC similarity (Derti et al .…”

Section: Discussionmentioning

confidence: 97%

“…For example, only 10 haplotypes make up the high-frequency majority for the Hutterite community (N = 1891 sampled) where a significant preference for MHC haplotype-dissimilar mating was detected (Ober et al 1997). Matching at six alleles (for six-locus haplotypes) could severely limit the potential antigenic detection range and/or interfere with maternal-foetal interactions (Ober et al 1988(Ober et al , 1997Lashley et al 2015). The Hutterite results are in line with the hypothesis of mate selection disfavouring extreme MHC similarity (Derti et al 2010), and our results also show that experimental study preferences for MHC-similar individuals had relatively few matching alleles between mates (average of 1-3 alleles).…”

Section: Evidence For Mate Choice For Mhc Optimality?mentioning

confidence: 99%

Patterns ofMHC‐dependent mate selection in humans and nonhuman primates: a meta‐analysis

et al. 2016

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Genes of the major histocompatibility complex (MHC) in vertebrates are integral for effective adaptive immune response and are associated with sexual selection. Evidence from a range of vertebrates supports MHC-based preference for diverse and dissimilar mating partners, but evidence from human mate choice studies has been disparate and controversial. Methodologies and sampling peculiarities specific to human studies make it difficult to know whether wide discrepancies in results among human populations are real or artefact. To better understand what processes may affect MHC-mediated mate choice across humans and nonhuman primates, we performed phylogenetically controlled meta-analyses using 58 effect sizes from 30 studies across seven primate species. Primates showed a general trend favouring more MHC-diverse mates, which was statistically significant for humans. In contrast, there was no tendency for MHC-dissimilar mate choice, and for humans, we observed effect sizes indicating selection of both MHC-dissimilar and MHC-similar mates. Focusing on MHC-similar effect sizes only, we found evidence that preference for MHC similarity was an artefact of population ethnic heterogeneity in observational studies but not among experimental studies with more control over sociocultural biases. This suggests that human assortative mating biases may be responsible for some patterns of MHC-based mate choice. Additionally, the overall effect sizes of primate MHC-based mating preferences are relatively weak (Fisher's Z correlation coefficient for dissimilarity Zr = 0.044, diversity Zr = 0.153), calling for careful sampling design in future studies. Overall, our results indicate that preference for more MHC-diverse mates is significant for humans and likely conserved across primates.

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“…One hypothesis is that in these HDP pregnancies the genetically foreign fetus induces immunological reactions and placental pathology, such as villitis, chronic deciduitis, and ischemic changes, in the oocyte recipient (Gundogan et al 2010;van der Hoorn et al 2010;Savasi et al 2016). Lashley et al suggested that HLA matching between donor and recipient might prevent the immunologic mismatch between mother and fetus thereby decreasing the risk of HDP and other obstetric and perinatal complications (Lashley et al 2015).…”

Section: Oocyte Donationmentioning

confidence: 99%

The health of children conceived by ART: ‘the chicken or the egg?’

Berntsen

Söderström‐Anttila

Wennerholm

et al. 2019

Human Reproduction Update

321

226

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Long-term health Neurodevelopmental health Cardiovascular function and metabolism Growth Respiratory and allergic disorders Malignancies Reproductive health Controlled ovarian stimulation Laboratory factors Culture media Culture time Number of embryos transferred Oocyte donation and gestational surrogacy Oocyte vitrification Epigenetics Imprinting disorders The chicken or the egg? Subfertility and sibling studies Future research Conclusion The conclusion we can reach from the well designed studies aimed at disentangling the influence on child health of parental and ART factors is that both the chicken and the egg matter.

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Selective advantage of HLA matching in successful uncomplicated oocyte donation pregnancies

Cited by 31 publications

References 29 publications

Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta‐analysis

Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta‐analysis

Patterns ofMHC‐dependent mate selection in humans and nonhuman primates: a meta‐analysis

The health of children conceived by ART: ‘the chicken or the egg?’

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