Selective and non-extractive spectrophotometric determination of cefdinir in formulations based on donor-acceptor complex formation

Abstract

Recebido em 29/9/09; aceito em 22/3/10; publicado na web em 30/7/10Cefdinir has broad spectrum of activity and high prescription rates, hence its counterfeiting seems imminent. We have proposed a simple, fast, selective and non-extractive spectrophotometric method for the content assay of cefdinir in formulations. The method is based on complexation of cefdinir and Fe under reducing condition in a buffered medium (pH 11) to form a magenta colored donoracceptor complex (l max = 550 nm; apparent molar absorptivity = 3720 L mol -1 cm -1). No other cephalosporins, penicillins and common excipients interfere under the test conditions. The Beer's law is followed in the concentration range 8-160 µg mL -1 .

Optimizing the spectrofluorimetric determination of cefdinir through a Taguchi experimental design approach

“…The literature reveals some methods for the determination of CFN in pharmaceutical preparations including: spectrophotometry , spectrofluorimetry , HPLC and electrochemical methods .…”

“…Most of the methods reported in the literature use sophisticated equipment like HPLC and electrochemical analysis , suffer from poor stability of the formed colored product or are time‐consuming . In addition, only one spectrofluorimetric method has been reported for the analysis of CFN, but it required a long reaction time (1 h) and high temperature (95°C).…”

Development and Validation of a Liquid Chromatographic Method for the Determination of Cefdinir Residues on Manufacturing Equipment Surfaces

“…The same equipment may be used for processing in different products, the cleaning procedure validation describe aresponsibilities, facilities, cleaning strategies, It is of great impotence to evaluate carefully the material to be used Chemically, Cefdinir is [6R- Non-extractive visible spectrophotometric method was proposed for the determination of cefdinir based on the formation of donoracceptor complex between Cefdinir and Fe in a buffered medium [2][3][4][5][6][7][8].…”

A New Chemometric Strategy in Electrochemical Method Optimization for the Quantification of Cefdinir in Tablets, Effervescent Tablets and Suspension Samples

“…In the literature, various analytical methods were described for the quantification of cefdinir alone and in combination with other drugs in pharmaceutical preparations and biological fluids using spectrofluorimetry [2], spectrophotometry [3][4][5], high-performance liquid chromatography [5][6][7][8][9][10][11], liquid chromatography-mass spectrometry [12][13][14], capillary electrophoresis-mass spectrometry [14]. Electrochemical behavior of cefdinir has been well reported in the literature [15][16][17][18].…”