Selective beta1 and beta2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs

Abstract

(6,34 +--0,74 vs 8,40 +--1,13Epinephrine exerts its effects on the heart through adrenergic receptors. Myocardial beta receptors have been considered to be one of the responsible receptors mediating the catecholamine-induced arrhythmias.l"4 Propranolol, a nonselective beta antagonist, l and 1-metoprolol, a selective beta I antagonist, 2 have been shown to prevent epinephrine-induced arrhythmia during halothane anaesthesia. Recent reports 5 have described the existence of both beta 1 and beta 2 adrenoceptors in the heart. 5-7 The effect of selective beta 2 antagonism on the genesis of the arrhythmias is controversial. Sharma, 3 using H 35/25 as a beta 2 antagonist, reported a weak protective effect against halothane-epinephrine arrhythmias and concluded that this action was attributed to its non-specific effect. On the other hand, we s examined the effect of a selective beta 2 antagonist, ICI-118,551, on the genesis of the arrhythmias provoked by various combinations of phenylephrine and isoproterenol, and showed that ICI-118,551 potentiated isoproterenol-induced arrhythmias in the presence of a low CAN J ANAESTH t992 / 39:8 / pp 873-6

Landiolol decreases a dysrhythmogenic dose of epinephrine in dogs during halothane anesthesia

“…is Several investigators have studied the dysrhythmogenicity and prevention of epinephrine-induced arrhythmias during halothane anesthesia. 12, 13 Dimich et all 2 demonstrated that esmolol prevented and suppressed arrhythmias in dogs during anesthesia with halothane, and also demonstrated that the dysrhythmogenic dose of epinephrine increased 10-fold and 30-fold above control values by administration of 150 pg.kg-~.min -1 and 200 pg-kg-l-min -1 esmolol, respectively. 12 We showed that the dysrhythmogenic dose of epinephrine increased 10-fold above the control values with an infusion of 10 pg-kgq.min -1 landiolol.…”

Efficacy of landiolol in attenuating hemodynamic responses to local epinephrine infiltration in patients undergoing vaginal total hysterectomy

“…Although no arrhythmias were observed following epinephrine infiltration in the present study, the worst adverse reaction to epinephrine is a life-threatening arrhythmia [2][3][4]. In addition, since it has been reported that 1 -adrenoceptors may be involved in the mechanism of epinephrine-induced arrhythmia [5], 1 -blockers could be effective for such arrhythmias [6] if they occur. Moreover, Takahashi et al [14] reported that landiolol increased the dysrhythmogenic dose of epinephrine in dogs during halothane anesthesia.…”