1983
DOI: 10.1007/bf00426391
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Selective brain noradrenaline depletion induced by the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP 4) does not prevent the memory facilitation induced by a muscarinic agonist in mice

Abstract: These experiments investigated the effects of central noradrenaline (NA) depletion and its interaction with cholinergic and dopaminergic mechanisms upon retention of a passive-avoidance response in mice. The NA selective neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP 4) (50 mg/kg IP, 7 days) was injected into mice to produce depletion of NA in frontal cortex, hypothalamus, cerebellum, midbrain and brain stem without any significant change in dopamine (DA) levels in frontal cortex, striatum, hypot… Show more

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Cited by 10 publications
(1 citation statement)
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“…The same con clusion seems to be true for other cholinergics too (e.g. oxotremorine, physostigmine, eserine) [Essman, 1971;Introini et al. 1984], The direction of the effect of cholin ergic drugs (impaired or enhanced performance) seems to be strongly dependent on dosage and the kind of task [Gold and Zornetzer, 1983;Warburton and Wesnes.…”
Section: Cholinergic Drugsmentioning
confidence: 96%
“…The same con clusion seems to be true for other cholinergics too (e.g. oxotremorine, physostigmine, eserine) [Essman, 1971;Introini et al. 1984], The direction of the effect of cholin ergic drugs (impaired or enhanced performance) seems to be strongly dependent on dosage and the kind of task [Gold and Zornetzer, 1983;Warburton and Wesnes.…”
Section: Cholinergic Drugsmentioning
confidence: 96%