Selective breeding for infant vocal response: A role for postnatal maternal effects?

Brunelli, Susan A.; Hofer, Myron A.; Weller, Aron

doi:10.1002/dev.1016

Cited by 17 publications

(13 citation statements)

References 30 publications

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“…This extended vocalization response, and inability of these pups to reduce ultrasonic calls prior to weaning (day 21) possibly reflects a subtle developmental delay produced by REMSR. These results strongly suggest an early onset of anxiety behaviour in these pups which is supported by evidences from previously published work [30], [42]. Report of reduced USVs on postnatal day 9 in the vasopressin 1b knockout mice shows the vulnerability of ultrasonic vocalizations, and possibly social bonding, during early development [43].…”

Section: Discussionsupporting

confidence: 86%

Reduction in Ultrasonic Vocalizations in Pups Born to Rapid Eye Movement Sleep Restricted Mothers in Rat Model

et al. 2014

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The effects of rapid eye movement sleep restriction (REMSR) in rats during late pregnancy were studied on the ultrasonic vocalizations (USVs) made by the pups. USVs are distress calls inaudible to human ears. Rapid eye movement (REM) sleep was restricted in one group of pregnant rats for 22 hours, starting from gestational day 14 to 20, using standard single platform method. The USVs of male pups were recorded after a brief isolation from their mother for two minutes on alternate post-natal days, from day one till weaning. The USVs were recorded using microphones and were analysed qualitatively and quantitatively using SASPro software. Control pups produced maximum vocalization on post-natal days 9 to 11. In comparison, the pups born to REMSR mothers showed not only a reduction in vocalization but also a delay in peak call making days. The experimental group showed variations in the types and characteristics of call types, and alteration in temporal profile. The blunting of distress call making response in these pups indicates that maternal sleep plays a role in regulating the neural development involved in vocalizations and possibly in shaping the emotional behaviour in neonates. It is suggested that the reduced ultrasonic vocalizations can be utilized as a reliable early marker for affective state in rat pups. Such impaired vocalization responses could provide an important lead in understanding mother-child bonding for an optimal cognitive development during post-partum life. This is the first report showing a potential link between maternal REM sleep deprivation and the vocalization in neonates and infants.

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Section: Discussionsupporting

confidence: 86%

Reduction in Ultrasonic Vocalizations in Pups Born to Rapid Eye Movement Sleep Restricted Mothers in Rat Model

et al. 2014

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“…Overall, the present findings are in line with studies of successful selective breeding for high or low calling rates in isolation (Brunelli 2005;Brunelli et al 1997Brunelli et al , 2001Brunelli et al , 2002Hofer et al 2001). Also, genetic analyses using reciprocal hybrids (Hahn et al 1987(Hahn et al , 1997(Hahn et al , 1998Hahn and Schanz 2002;Roubertoux et al 1996;Thornton et al 2005) revealed an influence of the genetic background on ultrasonic call emission; a finding, which is supported by studies on knockout mice.…”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andsupporting

confidence: 78%

“…With respect to the rat study by Brunelli et al (2001) it has to be mentioned that they bred their animals for high or low calling rates by using a within-litter selection procedure which minimizes maternal effects . Despite this selection procedure, however, Rojowsky et al (2000) found that dams from the line with high calling rates showed reduced maternal responsiveness compared to dams from lines with random or low calling rates.…”

Section: Within-strain Embryo-transfer: Comparison Between B6jola Andmentioning

confidence: 99%

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

et al. 2008

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Infant rodents emit ultrasonic vocalizations when isolated from dam and littermates. Due to the context of their occurrence and the well described bidirectional modulation by substances known for their capability to influence emotionality, it was postulated that such calls reflect a negative affective state akin anxiety. Comparative studies observed pronounced differences in calling behavior between strains, which were paralleled by differences in maternal care. Therefore, it was recently hypothesized that early environmental factors may have strong impact on call production. Here, the relative contributions of genetic background, gender, and early environmental factors on calling behavior in C57BL/6JOlaHsd and C57BL/6NCrl were studied by using an embryo-transfer procedure. The results show that these sub-strains differ in the amount of calling and specific call features, like call frequency and amplitude. The embryo-transfer procedure indicated that the observed differences in the amount of ultrasonic calling are dependent on the dyadic interaction between mother and pup. Conversely, call features were primarily dependent on the genotype of the pup. Thus, call frequency and frequency modulation were solely dependent on the pup, i.e. its genotype and gender. However, there was one exception, namely call amplitude, which was solely dependent on the genotype of the mother, i.e. on early environmental factors. Furthermore, it was shown that particularly changes in call amplitude might be of high functional relevance, since a sub-strain dependent preference towards pups emitting calls with high amplitudes was observed. In total, it can be concluded that both genomic and nongenomic factors can tune calling behavior in mouse pups.

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“…Pups in the S13 generation were cross-fostered within 48 h of birth between dams of the two lines, that is, Low-pups to High-dams and High-pups to Low-dams (Brunelli, Hofer, & Weller, 2001). To control for fostering effects, other groups of pups were fostered to dams within their own lines (in-fostered).…”

Section: A Possible Role For Epigenetic Effectsmentioning

confidence: 99%

Developmental Effects of Selective Breeding for an Infant Trait

Brunelli

Zimmerberg

Hofer

2010

Handbook of Developmental Science, Behavior, and Genetics

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Selective breeding for infant vocal response: A role for postnatal maternal effects?

Cited by 17 publications

References 30 publications

Reduction in Ultrasonic Vocalizations in Pups Born to Rapid Eye Movement Sleep Restricted Mothers in Rat Model

Reduction in Ultrasonic Vocalizations in Pups Born to Rapid Eye Movement Sleep Restricted Mothers in Rat Model

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

Developmental Effects of Selective Breeding for an Infant Trait

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