Selective cognitive deficits in adult rats after prenatal exposure to inhaled ethanol

Oshiro, Wendy M.; Beasley, Tracey E.; McDaniel, Katherine L.; Taylor, Miles G.; Evansky, Paul A.; Moser, Virginia C.; Gilbert, Mary E.; Bushnell, Philip J.

doi:10.1016/j.ntt.2014.07.001

Cited by 21 publications

(21 citation statements)

References 84 publications

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“…FAS is the most severe disorder in the fetal alcohol spectrum disorders (FASD) resulting from prenatal alcohol exposure. There are many FASD studies utilizing diverse alcohol injection methods and timings of injections; nevertheless, these animal models exhibit symptoms of FASD (Oshiro et al, 2014;Patten et al, 2014). Our results with the Morris water maze test to evaluate cognition in our model of FAS indicate that both control and ethanol-treated mice had learning and memory ability, but the ethanol-treated group had fewer achievements.…”

Section: Discussionmentioning

confidence: 71%

Effects of postnatal alcohol exposure on hippocampal gene expression and learning in adult mice

et al. 2015

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Fetal alcohol syndrome (FAS) is a condition resulting from excessive drinking by pregnant women. Symptoms of FAS include abnormal facial features, stunted growth, intellectual deficits and attentional dysfunction. Many studies have investigated FAS, but its underlying mechanisms remain unknown. This study evaluated the relationship between alcohol exposure during the synaptogenesis period in postnatal mice and subsequent cognitive function in adult mice. We delivered two injections, separated by 2 h, of ethanol (3 g/kg, ethanol/saline, 20% v/v) to ICR mice on postnatal day 7. After 10 weeks, we conducted a behavioral test, sacrificed the animals, harvested brain tissue and analyzed hippocampal gene expression using a microarray. In ethanol-treated mice, there was a reduction in brain size and decreased neuronal cell number in the cortex, and also cognitive impairment. cDNA microarray results indicated that 1,548 genes showed a > 2-fold decrease in expression relative to control, whereas 974 genes showed a > 2-fold increase in expression relative to control. Many of these genes were related to signal transduction, synaptogenesis and cell membrane formation, which are highlighted in our findings.

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Section: Discussionmentioning

confidence: 71%

Effects of postnatal alcohol exposure on hippocampal gene expression and learning in adult mice

et al. 2015

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“…The Nelson et al (1985a,b;1988) observations suggesting minimal toxicity of inhaled ethanol relative to ingested ethanol were supported by a recent series of studies designed to evaluate the role of ethanol in toxicity of gasoline-ethanol fuel blends Boyes et al, 2014;Oshiro et al, 2014). In these studies pregnant rats inhaled ethanol (5000 to 21,000 ppm) from GD 9 to 20, a critical period for CNS development (Rice and Barone, 2000).…”

Section: Introductionmentioning

confidence: 92%

“…Beginning after PND 76, assessments followed a two-day protocol as previously described (Gilbert, 2011;Oshiro et al, 2014). Animals were handled for 3-5 days prior to beginning these assessments.…”

Section: Trace Fear Conditioning [Cohort 1]mentioning

confidence: 99%

“…Spatial learning, reference memory, visual ability, and working memory were assessed in one male and one female randomly selected from each of 10 litters (n = 10/sex/concentration) in a Morris water maze (Morris, 1981), as previously described (Moser et al, 2001;Oshiro et al, 2014). These animals had previously been evaluated using functional observational battery and motor activity tests (Bushnell et al, 2015).…”

Section: Morris Water Maze [Cohort 2]mentioning

confidence: 99%

“…Working memory was also assessed in one male and one female from each of 8 litters (n = 8/sex/concentration) in the E0 experiment using a delayed match-to-sample appetitive operant procedure as previously described (Bushnell, 1990;Bushnell and Oshiro, 1996) except that discrimination trials were not used and only delayed matching trials were presented as in Oshiro et al (2014). Training began on PND 71.…”

Section: Delayed Matching-to-sample [Cohort 3 E0 Only]mentioning

confidence: 99%

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