Selective detection of ascorbic acid with wet-chemically prepared CdO/SnO2/V2O5 micro-sheets by electrochemical approach

Abstract

Generally, ascorbic acid (AA) is a potent reducing and antioxidant agent that regulates in fighting against bacterial infections as well as detoxifying reactions, which is functioned in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries. Up to date, electrochemical enzymatic sensor are significantly used for enzymatic AA detection that exhibits an excellent selectivity, high reliability and handled under physiological conditions. However, considering some intrinsic disadvantages of using enzymes, such as high fabrication cost and poor stability, non-enzymatic AA sensors have attracted increasing research interest in recent years owing to their low cost, high stability, fast response, and low detection limit. Moreover, the development of nanotechnology has also offered new opportunities to develop the nanostructured sensor probes for enzyme-less AA sensing applications. With beneficial advantages, ternary-doped metal oxides have gathered an extensive effort in the development of cost-effective sensors with high stability, sensitivity and quick response for the determination of selective AA by enzyme-free detection. In this approach, the mixed metal oxides of CdO/SnO 2 /V 2 O 5 micro-sheets (MSs) were prepared by facile wet-chemical method in alkaline phase at low temperature. Later, it was subjected to detail characterize by using various methods such as XPS, FESEM, EDS, and XRD. The slurry of prepared MSs in ethanol was deposited initially onto the surface of glassy carbon electrode (GCE) to make a thin film with conducting nafion (5% suspension in ethanol) adhesive to result the working electrode of proposed AA sensor probe. The sensor sensitivity (21.3354 μA μM −1 cm −2) is calculated by using the slope (0.6742 μA μM −1) of the calibration curve by considering the active surface area of GCE (0.0316 cm 2) in the linear dynamic range (LDR; 0.1 nM to 0.01 mM). The limit of detection (LOD) (98.64 ± 4.98 pM) is obtained from the calibration curve. The proposed AA electrochemical sensor exhibits short response time, good reproducibility and successive outcome during the investigation of the real biological samples. The development of enzyme-free AA sensor by using CdO/ SnO 2 /V 2 O 5 MSs onto GCE is simple as well as reliable and practically able to detect the biological stuffs for the safety of human health in the field of biomedical and sensor technology.

High performance Pt-anchored MoS2 based chemiresistive ascorbic acid sensor

“…When the AA biomolecules were exposed to the fabricated device, AA biomolecules were absorbed on the surface of the sensing layer, which transferred an electron to MoS 2 and resulted in an increase in the current of the device. The free electrons that are produced enhance both the device response (I DS ) and the conductivity of the sensing layer [54]. Under the influence of applied bias voltage (V b ), AA begins to oxidize and produces dehydroascorbic acid, two free electrons, and two protons as shown in the equation (3),…”

Low Overpotential Amperometric Sensor Using Yb2O3.CuO@rGO Nanocomposite for Sensitive Detection of Ascorbic Acid in Real Samples

“…Previously, researchers have investigated various types of metal oxides, such as CuO [ 22 , 23 ], MnO 2 [ 24 ], NiO [ 25 ], Fe 2 O 3 [ 26 ], and ZnO [ 27 ], as electron mediators for sensing applications. Additionally, doped metal oxides, such as NiO.CoO nanocomposites [ 28 ], CdO.SnO 2 .V 2 O 5 [ 29 ], CuO.In 2 O 3 [ 30 ], CuO.Nd 2 O 5 [ 31 ], CuO.NiO [ 32 ], and CuO.ZnO [ 33 ], have been studied as efficient sensing materials with higher sensitivity, small detection limits, wide linear dynamic ranges, and quick response times. CuO, a p -type semiconductor, has shown particularly good performance as an electrocatalyst in sensing applications [ 34 ].…”

Iron/Iron(III) Oxide Decorated on Electrochemically Reduced Graphene Oxide: a Novel One-Step Electrosynthesis and a Fabrication of an Electrochemical Ascorbic Acid Sensor

“…[1][2][3][4][5]11,17 For electrochemical AA sensing, nanocomposite-based transition metals (such as rGO/PdNPs, 4 rGO-AuNPs, 3 rGO/polypyrrole-Pt 2 ) or transition metal oxides (such as Fe 2 O 3 /graphene, 5 Co 3 O 4 .Fe 2 O 3 nanospheres 1 ) have been widely used for modifying working electrodes. For example, M. M. Alam 18 has reported an electrochemical AA sensor using a glassy carbon electrode (GCE) modified by CdO/SnO 2 /V 2 O 5 micro-sheets (MSs). The developed sensor has a linear detection range from 0.10 nM to 0.01 mM with a sensitivity of 21.3354 μA μM −1 cm −2 and a limit of detection (LOD) of 98.64 ± 4.98 pM, meanwhile the required detection time is only 20 s. 17,19 In fact, Fe 2 O 3 nanoparticles is a semiconductor material with a narrow gap of 2.21 eV, 20 however, with high stability under alkaline or acidic conditions, low cost, easy availability, and environmentally friendly, the Fe 2 O 3 are considered as an attractive electrochemically capture probe for AA oxidation.…”