Selective Determination of Phenylpropanolamine Hydrochloride in Pharmaceutical Dosage Forms by Reaction with Ninhydrin

Burke, D.; Venturella, Vincent S.; Senkowski, Bernard Z.

doi:10.1002/jps.2600630221

Journal of Pharmaceutical Sciences

1974

DOI: 10.1002/jps.2600630221

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Selective Determination of Phenylpropanolamine Hydrochloride in Pharmaceutical Dosage Forms by Reaction with Ninhydrin

D. Burke

Vincent S. Venturella

Bernard Z. Senkowski

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1978

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Cited by 8 publications

(1 citation statement)

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“…As per the literature [7], present com pound has antifungal potency which was stimulated by the injection of amino group in ethyl part. By the application of biological reaction mechanism, the present molecule possessed bioactivity [8] and also acted as catalytic ability.…”

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confidence: 94%

Molecular structure analysis and biological properties investigation on antiseptic drug; 2-amino-1-phenyl-1-propanol using spectroscopic and computational research analysis

Manthiri¹,

Ramalingam²,

George³

et al. 2021

Heliyon

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The inducement of physical, chemical, structural and biological properties to entice of pharmaceutical property was analyzed by Vibrational spectroscopic, biological and theoretical tools. The structural arrangement for describing structure activity was investigated by injecting ligand groups in internal coordinate system by molecular tools (FT adopted IR, Raman, and NMR). Bond length and bond angle strain was pronounced much due to the chemical equivalent forces extension due to the injection of substitutional groups on base compound and thus non-Centro symmetry was processed. The molecular charge depletion profile was thoroughly studied to persuade protonic and electronic delocalization setup for arranging the drug potential. The chemi-equivalent potential exchange was monitored among different parts of the molecule for obtaining drug mechanism. The biological profile was keenly observed to look at the biological ambiance of the present molecule to fabricate advanced drug. The Lipinski five rule parameters; M V = 137.18, LogP = 0.27, HBD = 2, HBA = 2 and TPSA = 46.2 A 2 showed the enhancement of additive drug quality. The exchange of oscillating chemical energy in the core and allied carbons of the base skeleton was keenly noted to find the prearranged chemical environment for successful drug mechanism. The non bonded transitions between Lewis acid and base of bonded molecular system were observed to determine the restoring potential to customize drug potential. The drug assistance for enantiomer characteristics of chirality sequence was displayed to expose the toxicity effect of the molecule. The active molecular bondings on different sites of molecule were measured by estimating polarizability and associated biological inhibition was validated.

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mentioning

confidence: 94%

Molecular structure analysis and biological properties investigation on antiseptic drug; 2-amino-1-phenyl-1-propanol using spectroscopic and computational research analysis

Manthiri¹,

Ramalingam²,

George³

et al. 2021

Heliyon

View full text Add to dashboard Cite

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Quantitative Determinations of Two Decongestants and an Antihistamine in Combination Using Paired Ion High-Pressure Liquid Chromatography

Ghanekar

Gupta

1978

Journal of Pharmaceutical Sciences

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Determination of Phenylpropanolamine Salts in Dosage Forms through Fluorescent Derivative Formation

Shankle

1978

Journal of Pharmaceutical Sciences

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Selective Determination of Phenylpropanolamine Hydrochloride in Pharmaceutical Dosage Forms by Reaction with Ninhydrin

Cited by 8 publications

References 9 publications

Molecular structure analysis and biological properties investigation on antiseptic drug; 2-amino-1-phenyl-1-propanol using spectroscopic and computational research analysis

Molecular structure analysis and biological properties investigation on antiseptic drug; 2-amino-1-phenyl-1-propanol using spectroscopic and computational research analysis

Quantitative Determinations of Two Decongestants and an Antihistamine in Combination Using Paired Ion High-Pressure Liquid Chromatography

Determination of Phenylpropanolamine Salts in Dosage Forms through Fluorescent Derivative Formation

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