Selective disappearance of essential tremor after ischaemic stroke

Pira, Francesco Le; Giuffrida, Salvatore; Panetta, M. R.; Bartolo, Michelangelo; Politi, G

doi:10.1111/j.1468-1331.2004.00824.x

Cited by 12 publications

(7 citation statements)

References 10 publications

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“…Le Pira et al4 reported the observation of a patient with a disabling familial ET. After a transitory paresis, tremor of the right hand but not of the foot disappeared during 6 months, and reappeared as a discrete tremor within 2 years of follow‐up.…”

Section: Discussionmentioning

confidence: 99%

Disappearance of essential tremor after stroke

et al. 2010

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Improvement of a patient's essential tremor (ET) after a stroke has rarely been reported. In such patients, cerebral imaging could help to identify structures involved in the maintenance of ET and improves the knowledge of its physiopathology. This article reports the disappearance of ET, after a stroke in 4 patients and reviews similar previously published cases. These cases suggest that the interruption of cerebellar loops during a stroke could be responsible for the disappearance of ET.

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Section: Discussionmentioning

confidence: 99%

Disappearance of essential tremor after stroke

et al. 2010

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“…Studies using electrophysiological and functional neuroimaging observations suggest an association between abnormal activations in the central nervous system, for example, the cerebellum, the thalamus, and the medulla, and ET 1, 6, 7. In addition, it is well known that a tremor can be abolished by a stereotaxic lesion of the contralateral nucleus ventralis intermedius of the thalamus or by a vascular lesion involving the thalamus, cerebellum, pons, corona radiate, or frontal lobe 2–4, 8–10…”

Section: Discussionmentioning

confidence: 99%

Disappearance of essential tremor after frontal cortical infarct

Kim¹,

Park²,

Kim³

et al. 2006

Mov Disord.

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“…1 The pathophysiology of ET is uncertain, although cerebellar dysfunction has been reported in many imaging and animal studies. 2,3 However, the disappearance of ET after cortical infarction has been reported, 4,5 and ET reportedly was reset by a single magnetic shock over the primary motor cortex (M1). 6 Moreover, regional cortical activity reportedly was correlated with tremor frequency.…”

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confidence: 99%

Reduced cortical plasticity and GABAergic modulation in essential tremor

Chuang

Huang

et al. 2014

Movement Disorders

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Essential tremor (ET) is the most common movement disorder among adults. Cerebellar dysfunction is thought to be involved in the pathogenesis of ET; however, imaging, electrophysiological studies, and clinical observations have suggested that the cerebral cortex also may participate. We sought to investigate the possible motor cortical contribution to ET by assessing response to continuous theta-burst stimulation (cTBS), a recognized tool that can produce transient plastic changes, in the primary motor and premotor cortex of patients with ET. We compared parameters, including motor-evoked potential amplitude, cortical silent period, and short-interval intracortical inhibition, before and after applying cTBS in healthy controls and patients with ET. We found that, although cTBS applied to either the motor or premotor cortex was capable of producing a suppressive effect on motor cortical excitability in ET patients, the effects lasted for a significantly shorter time compared with the effect produced in healthy individuals. The change seen in measures of intracortical inhibition after motor cortical or premotor cTBS in healthy controls was reduced or absent in the ET patients. Tremor amplitude was decreased significantly after applying cTBS over either the motor or premotor cortex, but the tremor frequency remained unchanged. These findings suggest that inhibitory circuits within the motor cortex are aberrant and less modifiable in ET patients. The reduced plasticity in response to motor and premotor TBS supports the theory of abnormal gamma-aminobutyric acid (GABA) modulation in ET.

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Selective disappearance of essential tremor after ischaemic stroke

Cited by 12 publications

References 10 publications

Disappearance of essential tremor after stroke

Disappearance of essential tremor after stroke

Disappearance of essential tremor after frontal cortical infarct

Reduced cortical plasticity and GABAergic modulation in essential tremor

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