Selective droplet sampling using a minimum number of horizontal pneumatic actuators in a high aspect ratio and highly flexible PDMS device

Yoon, Dong Hyun; Wakui, Daisuke; Nakahara, Asahi; Sekiguchi, Tetsushi; Shoji, Shuichi

doi:10.1039/c4ra11254g

Cited by 13 publications

(12 citation statements)

References 32 publications

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“…Compared to the previously reported two mechanical sorters using vertical wall based in-plane pneumatic valves, 12,13 our bilayer valve based sorter provided a higher sorting frequency than the one with five sampling outlets ($2 Hz), 12 but lower than the other with two sampling outlets ($250 Hz). 13 The moderate sorting frequency of our sorter may perhaps be caused by the indirect body contact of the droplets with the valves and the moderate number of sampling outlets.…”

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confidence: 55%

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Microfluidic droplet sorting using integrated bilayer micro-valves

Chen

Yang

et al. 2016

Applied Physics Letters

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This paper reports on a microfluidic device capable of sorting microfluidic droplets utilizing conventional bilayer pneumatic micro-valves as sorting controllers. The device consists of two micro-valves placed symmetrically on two sides of a sorting area, each on top of a branching channel at an inclined angle with respect to the main channel. Changes in transmitted light intensity, induced by varying light absorbance by each droplet, are used to divert the droplet from the sorting area into one of the three outlet channels. When no valve is activated, the droplet flows into the outlet channel in the direction of the main channel. When one of the valves is triggered, the flexible membrane of valve will first be deflected. Once the droplet leaves the detection point, the deflected membrane will immediately return to its default flattened position, thereby exerting a drawing pressure on the droplet and deviating it from its original streamline to the outlet on the same side as the valve. This sorting method will be particularly suitable for numerous large-scale integrated microfluidic systems, where pneumatic micro-valves are already used. Only few structural modifications are needed to achieve droplet sorting capabilities in these systems. Due to the mechanical nature of diverting energy applied to droplets, the proposed sorting method may induce only minimal interference to biological species or microorganisms encapsulated inside the droplets that may accompany electrical, optical and magnetic-based techniques. Published by AIP Publishing.

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confidence: 55%

“…6,7 Optical, acoustic, and mechanical methods have also been used to achieve sorting. [8][9][10][11][12][13] To improve sorting efficiency, some passive means of sorting also utilize external fields. [14][15][16] A modification to the pinched flow fractionation method involves applying a laser beam to particles for improved sorting efficiency.…”

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confidence: 99%

Microfluidic droplet sorting using integrated bilayer micro-valves

Chen

Yang

et al. 2016

Applied Physics Letters

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“…Subsequently, more devices developed using this method made use of the smaller valve length 87,88 . In 2015, Yoon et al 86 proposed a new design making use of the this device first uses microvalves to block the main channel to enable the droplet to move down towards the sorting channels. Following that, another set of microvalves are used to squeeze the walls of the collection chambers to reveal an opening for the droplet to enter.…”

Section: 4 2 Microvalvesmentioning

confidence: 99%

“…Pneumatic controls for droplet coalescence require microvalves as the droplets have to be trapped first before merging can take place. The microvalves for this purpose are also similar to the ones mentioned for droplet sorting where they are either on the side of the microchannels 85,86 or directly on top of it 84 . The former is used in conjunction with micropillar arrays that trap the droplets in their position due to the interfacial tension against the micropillars.…”

Section: 4 Pneumatic Controlmentioning

confidence: 99%

Technological Development – Droplet as a Tool

Teo

Tan

Nguyen

2020

Droplet Microfluidics

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The high uptake of droplet microfluidics in multidisciplinary research is mainly due to its capability of being a micro-scale laboratory with high versatility in controlling each microreactor. Through the implementation of three main manipulation methods, multiple reactions can be produced and subsequently used for different applications.Droplets of a predetermined mediums are first generated. Subsequently, the coalescence of different droplets can also take place to mix different reagents. Finally, sorting of droplets according to pre-set variables are carried out, facilitating analysis of results. Each manipulation method, however, can be carried out using a variety of active control methods. These can be categorised into electrical, magnetic, thermal, pneumatic, and occasionally acoustic and optical means. Further elaborations are provided in this chapter to illustrate these methods with the repertoire of mechanisms developed for these purposes. The advancement of such techniques enables high selectivity with minimal waste of resources, reducing the carbon footprint of laboratories while concurrently pursuing science.

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“…Of the numerous kinds of element technologies, target sorting or separation is one of the key technologies in enhancing the efficiency and reliability of the experiments. Specific targets are categorized by optical [ 6 , 7 ], electrical [ 8 , 9 ], thermal [ 10 , 11 ], acoustic [ 12 , 13 ], and pneumatic [ 14 , 15 ] detection or response.…”

Section: Introductionmentioning

confidence: 99%

Size-Dependent and Property-Independent Passive Microdroplet Sorting by Droplet Transfer on Dot Rails

et al. 2018

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A fully passive microdroplet sorting method is presented in this paper. On the rails with dot patterns, the droplets were sorted in different ways depending on their size. However, the effect of droplet properties on the threshold size of the sorting was eliminated. The droplet positions on two railways and the Laplace pressure of the droplets on the dot patterns allowed selective droplet transfer according to size. Different gaps between the rails altered the threshold size of the transfer. However, the threshold size was independent of the droplet’s surface tension and viscosity because the droplet transfer utilized only the droplet position and Laplace pressure without lateral flow to sort targets. This feature has a high potential for bio/chemical applications requiring categorization of droplet targets consisting of various mixtures as pre- or post-elements.

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Selective droplet sampling using a minimum number of horizontal pneumatic actuators in a high aspect ratio and highly flexible PDMS device

Abstract: This paper presents a droplet sampling device driven by horizontal pneumatic actuators.

Cited by 13 publications

References 32 publications

Microfluidic droplet sorting using integrated bilayer micro-valves

Microfluidic droplet sorting using integrated bilayer micro-valves

Technological Development – Droplet as a Tool

Size-Dependent and Property-Independent Passive Microdroplet Sorting by Droplet Transfer on Dot Rails

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