Malignant glioma is a fatal brain tumor whose pathological progression is closely associated with glycolytic reprogramming, leading to the high expression of monocarboxylate transporter 1 (MCT1) and its ancillary protein, cluster of differentiation 147 (CD147) for enhancing lactate efflux. In particular, malignant glioma cells (GMs) release tremendous number of exosomes, nanovesicles of 30 to 200 nm in size, promoting tumor progression by the transport of pro-oncogenic molecules to neighboring cells. In the present study, we found that hypoxia-induced malignant GMs strongly enhanced MCT1 and CD147 expression, playing a crucial role in promoting calcium-dependent exosome release. Furthermore, it was first identified that hypoxic GMs-derived exosomes contained significantly high levels of MCT1 and CD147, which could be quantitatively detected by noninvasive localized surface plasmon resonance and atomic force microscopy biosensors, demonstrating that they could be precise surrogate biomarkers for tracking parent GMs’ metabolic reprogramming and malignant progression as liquid biopsies.

A flexible wood-templated piezoelectric ultrasonic energy harvester exhibits a high output voltage and power, demonstrating potential applications in implantable devices.

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Ultraviolet (UV) illumination can effectively shorten the statistical lag and jitter in gas breakdown processes. The spark gap discharge can produce abundant spectrum including UV waveband. In this paper, a simple but reliable spark gap operating with N 2 at atmospheric pressure is used to test optical radiation characteristics, such as spectrum intensity, rise time, fall time, and duration of optical pulse, which are adjusted by changing the circuit or configuration parameters. Three UV-illuminated switches with different UV spark gap configurations have been tested. The experimental results approve our assumption. With a uniform electric field UV spark gap, the breakdown voltage standard deviation percentage of the switch is 0.74%.Index Terms-Breakdown characteristics, jitter, optical pulse parameter, pulsed power technology, pulsed switch, ultraviolet (UV) illumination.

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