Determination of glioma cells’ malignancy and their response to TMZ via detecting exosomal BIGH3 by a TiO2-CTFE-AuNIs plasmonic biosensor

Xu, Chunping; Thakur, Abhimanyu; Li, Zebiao; Yang, Tian; Zhao, Chenghao; Li, Yangyang; Lee, Youngjin; Wu, Chi‐Man Lawrence

doi:10.1016/j.cej.2021.128948

Cited by 26 publications

(19 citation statements)

References 35 publications

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“…In addition to magnetic resonance imaging (MRI) and computed tomography (CT) scans, intracranial biopsies have been proposed for the diagnosis and prognosis of glioma [ 10 ]. Due to excellent improvement in sensitivity, the TiO2-CTFE-AuNIs real-time label‐free plasmonic biosensor demonstrated a good potential in detecting of prognostic biomarkers in GMs-derived exosomes for application in glioma liquid biopsy [ 11 ]. Exosomes derived from glioma which releases a great number of them in the tumor microenvironment (TME), are a type of extracellular vehicles (EVs) with a size range of 30–200 nm, and aggregates in a wide range of extracellular milieu and bio-fluids including blood, urine, and cerebrospinal fluid, with a crucial role in cell–cell communication [ 12 ].…”

Section: Exosomes and Extracellular Vesiclesmentioning

confidence: 99%

Exosome-based strategies for diagnosis and therapy of glioma cancer

et al. 2022

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Glioblastoma belongs to the most aggressive type of cancer with a low survival rate that is characterized by the ability in forming a highly immunosuppressive tumor microenvironment. Intercellular communication are created via exosomes in the tumor microenvironment through the transport of various biomolecules. They are primarily involved in tumor growth, differentiation, metastasis, and chemotherapy or radiation resistance. Recently several studies have highlighted the critical role of tumor-derived exosomes against immune cells. According to the structural and functional properties, exosomes could be essential instruments to gain a better molecular mechanism for tumor understanding. Additionally, they are qualified as diagnostic/prognostic markers and therapeutic tools for specific targeting of invasive tumor cells such as glioblastomas. Due to the strong dependency of exosome features on the original cells and their developmental status, it is essential to review their critical modulating molecules, clinical relevance to glioma, and associated signaling pathways. This review is a non-clinical study, as the possible role of exosomes and exosomal microRNAs in glioma cancer are reported. In addition, their content to overcome cancer resistance and their potential as diagnostic biomarkers are analyzed.

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Section: Exosomes and Extracellular Vesiclesmentioning

confidence: 99%

Exosome-based strategies for diagnosis and therapy of glioma cancer

et al. 2022

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“…ESCRT-mediated MVB biogenesis is the most extensively described pathway, and it depends on cell type or intracellular homeostasis ( 20 , 21 ). Some studies pointed out that exosomes were considered promising biomarkers for the diagnosis, treatment, and prognosis of various diseases, especially those that played a key role in the establishment of tumor microenvironment, tumor progression, invasion, metastasis, chemoresistance, and targeted drug delivery ( 14 , 22 – 26 ).…”

Section: Biogenesis and Function Of Exosomementioning

confidence: 99%

The Biological Functions and Clinical Values of Exosomal Circular RNAs in Hepatocellular Carcinoma

Zhao

Yao

2022

Front. Oncol.

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Hepatocellular carcinoma (HCC) exacts a heavy disease burden and is currently the second most common cause of cancer-related deaths worldwide. HCC usually lacks obvious symptoms in the early stage, and most HCC patients are diagnosed at advanced stages with poor prognosis. Circular RNAs (circRNAs) are single-stranded RNAs that form covalently closed loops and are stable in exosomes. Exosomes are known as important messengers of the cross-talk between tumor and immune cells. Accumulating studies have demonstrated the promoter or suppressor roles of exosomal circRNAs in the carcinogenesis, progression, and metastasis of HCC. In this review, we summarized the current studies on the biological functions and diagnostic and prognostic values of exosomal circRNAs in HCC progression.

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“…Thus, TiO2-CTFE-AuNIs was reported to be capable of quantifying the dynamic change in exosomal BIGH3 in response to hypoxia and TMZ therapy. This allows the measurement of BIGH3 levels in parent GMs, revealing TMZ’s anti-cancer impact; this makes the biosensor mentioned above show significant promise for its applicability to the identification of predictive biomarkers in GM-derived exosomes for glioma liquid biopsy ( 109 ). Even though there is a great job done about using exosomes as diagnostic and prognostic biomarkers, there is a need for deep researches to prove that exosomes can be used to monitor various therapies in glioma, which can be used in daily clinical life.…”

Section: The Application Of Exosomes As Future Biomarkers and Therapeutic Options For Gliomamentioning

confidence: 99%

The Roles of Exosomes as Future Therapeutic Agents and Diagnostic Tools for Glioma

Wang

et al. 2021

Front. Oncol.

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Glioma is a common type of tumor originating in the brain. Glioma develops in the gluey supporting cells (glial cells) that surround and support nerve cells. Exosomes are extracellular vesicles that contain microRNAs, messenger RNA, and proteins. Exosomes are the most prominent mediators of intercellular communication, regulating, instructing, and re-educating their surrounding milieu targeting different organs. As exosomes’ diameter is in the nano range, the ability to cross the blood–brain barrier, a crucial obstacle in developing therapeutics against brain diseases, including glioma, makes the exosomes a potential candidate for delivering therapeutic agents for targeting malignant glioma. This review communicates the current knowledge of exosomes’ significant roles that make them crucial future therapeutic agents and diagnostic tools for glioma.

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Determination of glioma cells’ malignancy and their response to TMZ via detecting exosomal BIGH3 by a TiO2-CTFE-AuNIs plasmonic biosensor

Cited by 26 publications

References 35 publications

Exosome-based strategies for diagnosis and therapy of glioma cancer

Exosome-based strategies for diagnosis and therapy of glioma cancer

The Biological Functions and Clinical Values of Exosomal Circular RNAs in Hepatocellular Carcinoma

The Roles of Exosomes as Future Therapeutic Agents and Diagnostic Tools for Glioma

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