Selective Effects of Ionizing Radiations on Immunoregulatory Cells

Doria, Gino; Agarossi, G.; Adorini, Luciano

doi:10.1111/j.1600-065x.1982.tb00426.x

Cited by 50 publications

(15 citation statements)

References 64 publications

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“…The results showed that macrophages of irradiated mice, regardless of their age, facilitated the PHA response of macrophage-deficient indicator cultures in the presence of excess IL-2 to the same ex tent as macrophages from unirradiated con trol mice. This confirms earlier findings demonstrating the radioresistance of macro phages and radiosensitivity of their precur sors [6],…”

Section: Discussionsupporting

confidence: 81%

A T Cell Model for Age-Related Loss of Homeostasis: Identification of the Cell Type Responsible for Age-Related Delay in Recovery of the PHA-Induced Mitogenic Response from Radiation Injury

Peterson¹,

Yelin²,

Crawford³

1986

Gerontology

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Immunologic recovery from radiation injury was used to assess age-related loss of immunologic homeostasis. Mice were exposed to 500 rad to determine whether macrophages, T helper cells and/or T responder cells were responsible for the age-related delay in recovery of PHA-induced mitogenesis. Recovery of macrophages was determined by facilitation of macrophage-deficient cultures, recovery of T helper cells by interleukin 2 production, and recovery of T responder cells by incorporation of tritiated thymidine. The results showed that in old mice (a) macrophages are resistant to radiation and aging, (b) T helper cells recover completely from radiation, and (c) recovery is incomplete for T responder cells.

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Section: Discussionsupporting

confidence: 81%

A T Cell Model for Age-Related Loss of Homeostasis: Identification of the Cell Type Responsible for Age-Related Delay in Recovery of the PHA-Induced Mitogenic Response from Radiation Injury

Peterson¹,

Yelin²,

Crawford³

1986

Gerontology

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“…The inhibition of antibody generation by the ioniz ing radiation is in agreement with the well-known high radiosensitivity of B cells [8]. B cells are more ra diosensitive than T cells.…”

Section: Discussionsupporting

confidence: 71%

“…Two groups of suppres sor cells should be distinguished, namely antigen-spe cific suppressor T cells (Tsag) and nonspecific sup pressor T cells (Tsns). Antigen-activated Tsag cells are more radiosensitive than the other T cell population [8]. There is some evidence that Tsns cells as induced by Freund's adjuvant might be radioresistant.…”

Section: Discussionmentioning

confidence: 93%

Protection against Experimental Allergic Encephalomyelitis with Complete Freund’s Adjuvant Is Unaffected by Ionizing Irradiation

Weber¹,

Hempel²

1987

Int Arch Allergy Immunol

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Long-lasting resistance to experimental allergic encephalomyelitis (EAE) was obtained in Lewis rats either by an immunization with complete Freund’s adjuvant blended with aluminum hydroxide (ALU-CFA) or by convalescence from EAE. Total body irradiation at a dose of 500 R given both 1 day after ALU-CFA (or disease induction) and EAE challenge did not abrogate the protection. No antibodies against myelin basic protein could be detected in irradiated animals. In contrast high antibody titers were measured in non-irradiated controls recovered from EAE and subsequently resistant to the disease. Therefore it is unlikely that antibodies against myelin basic proteins are of any importance in protection from EAE. The studies suggest that unspecific radioresistant suppressor cells play a role in resistance to EAE.

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“…Suppressor T cells are known to be more radiosensitive than other T cell subpopulations (Basten et al, 1975;Dutton, 1975) and this is thought to explain observed augmentation of immune responses following low-dose ionizing radiation (Anderson et al, 1981;Doria et al, 1982). Radiation may also enhance antigen processing by macrophages, leaving their phagocytic and migratory behaviour intact (Anderson & Warner, 1976).…”

Section: Discussionmentioning

confidence: 99%

In vivo detection and partial characterization of effector and suppressor cell populations in spleens of mice with large metastatic fibrosarcomas

Dent¹,

Finlay‐Jones²

1985

Br J Cancer

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Summary The MC-2 fibrosarcoma, which is a transplantable tumour syngeneic for BALB/c mice, metastasizes to lymph nodes draining subcutaneous inoculation sites, and also to the lungs. T cell-mediated immunity was detected in Winn assays using spleens from excision immunized mice. T cell-mediated antitumour immunity was also detected in spleens from mice with small tumours but disappeared as the tumour burden increased. Protective immune spleen cell activity in the Winn assay was inhibited by prior addition of spleen cells from mice with large tumours, causing increased tumour incidence. Splenic metastases occasionally occurred in the MC-2 model, but were not demonstrable by bioassay in any of the experiments detecting splenic suppressor cell activity. In vivo protective activity was restored to advanced-stage tumourbearer spleens by whole-body ionizing irradiation (0.5 and 2.5 Gy) of donor mice 15 h before sampling. Spleen cells from mice with small tumours remained protective after 1.5, 2.5 and 4.0 Gy of irradiation in vivo. These results are consistent with the properties of radiosensitive suppressor T cells. In contrast to reports in other tumour models, suppressor cells were not detected until late in the course of MC-2 development. This is surprising in view of the aggressively metastatic nature of MC-2. It is postulated that modulation of the antitumour immune response by the suppressor cells is associated with metastasis in this tumour model. The late appearance of both suppressor cells and metastatic cells in the spleen may reflect similar processes occurring earlier in regional lymph nodes.

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Selective Effects of Ionizing Radiations on Immunoregulatory Cells

Cited by 50 publications

References 64 publications

A T Cell Model for Age-Related Loss of Homeostasis: Identification of the Cell Type Responsible for Age-Related Delay in Recovery of the PHA-Induced Mitogenic Response from Radiation Injury

A T Cell Model for Age-Related Loss of Homeostasis: Identification of the Cell Type Responsible for Age-Related Delay in Recovery of the PHA-Induced Mitogenic Response from Radiation Injury

Protection against Experimental Allergic Encephalomyelitis with Complete Freund’s Adjuvant Is Unaffected by Ionizing Irradiation

In vivo detection and partial characterization of effector and suppressor cell populations in spleens of mice with large metastatic fibrosarcomas

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