Selective expression of NKG2-A and NKG2 - C mRNAs and novel alternative splicing of 5′ exons in rhesus monkey decidua

Kravitz, Rachel H.; Grendell, Richard L.; Slukvin, Igor I.; Golos, Thaddeus G.

doi:10.1007/s002510000289

Cited by 12 publications

(10 citation statements)

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“…Whereas HLA-G is recognized by several immunoglobulin (Ig)-superfamily receptors expressed on NK cells and macrophages (e.g., ILT-2/LIR-1 [29], ILT-4/ LIR-2 [30], KIR2DL4 [31]), HLA-E is recognized by heterodimeric receptors of the C-lectin superfamily [32], composed of one subunit of CD94 and one molecule of an NKG2 family member. To define the putative Mamu-E receptors in the rhesus decidua, we screened a decidual library for CD94 and NKG2 cDNAs [33]. Surprisingly, we only found NKG2-A and -C transcripts, suggesting selective expression of these genes in decidual leukocytes, because the expression of NKG2-B and D mRNAs in rhesus peripheral blood mononuclear cells has been demonstrated previously [34].…”

Section: Mhc Receptor Populations On Uterine Leukocytesmentioning

confidence: 82%

Nonhuman primate placental MHC expression: a model for exploring mechanisms of human Maternal-Fetal immune tolerance

Golos

2003

Human Immunology

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Section: Mhc Receptor Populations On Uterine Leukocytesmentioning

confidence: 82%

Nonhuman primate placental MHC expression: a model for exploring mechanisms of human Maternal-Fetal immune tolerance

Golos

2003

Human Immunology

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“…Genes related to human and chimpanzee CD94 and NKG2 have been described for rhesus monkey (48,49), mouse (50 -55), and rat (56 -58). Phylogenetic comparison of the genes from the five species gives trees with major branches corresponding to the three lineages: CD94, NKG2D, and a third lineage consisting of human NKG2A, C, E, F, and related genes from other species (Fig.…”

Section: Discussionmentioning

confidence: 99%

Conservation and Variation in Human and Common Chimpanzee CD94 and NKG2 Genes

Shum

Flodin

Muir

et al. 2002

The Journal of Immunology

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To assess polymorphism and variation in human and chimpanzee NK complex genes, we determined the coding-region sequences for CD94 and NKG2A, C, D, E, and F from several human (Homo sapiens) donors and common chimpanzees (Pan troglodytes). CD94 is highly conserved, while the NKG2 genes exhibit some polymorphism. For all the genes, alternative mRNA splicing variants were frequent among the clones obtained by RT-PCR. Alternative splicing acts similarly in human and chimpanzee to produce the CD94B variant from the CD94 gene and the NKG2B variant from the NKG2A gene. Whereas single chimpanzee orthologs for CD94, NKG2A, NKG2E, and NKG2F were identified, two chimpanzee paralogs of the human NKG2C gene were defined. The chimpanzee Pt-NKG2CI gene encodes a protein similar to human NKG2C, whereas in the chimpanzee Pt-NKG2CII gene the translation frame changes near the beginning of the carbohydrate recognition domain, causing premature termination. Analysis of a panel of chimpanzee NK cell clones showed that Pt-NKG2CI and Pt-NKG2CII are independently and clonally expressed. Pt-NKG2CI and Pt-NKG2CII are equally diverged from human NKG2C, indicating that they arose by gene duplication subsequent to the divergence of chimpanzee and human ancestors. Genomic DNA from 80 individuals representing six primate species were typed for the presence of CD94 and NKG2. Each species gave distinctive typing patterns, with NKG2A and CD94 being most conserved. Seven different NK complex genotypes within the panel of 48 common chimpanzees were due to differences in Pt-NKG2C and Pt-NKG2D genes.

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“…We have shown that homologs of these receptors for HLA-G are expressed in rhesus decidual leukocytes (Kravitz, et al ., 2001; Grendell et al ., 2001). In addition, the rhesus also expresses orthologs of CD94 and NKG2A, B, C, D, and E, some of which form heteodimeric receptors for HLA-E (Kravitz et al ., 2001; Labonte et al, 2000).…”

Section: Characterization Of the Rhesus Model: Maternal Componentsmentioning

confidence: 99%

“…In addition, the rhesus also expresses orthologs of CD94 and NKG2A, B, C, D, and E, some of which form heteodimeric receptors for HLA-E (Kravitz et al ., 2001; Labonte et al, 2000). Additional crucial reagents are required in order to move the field of experimental reproductive immunology forward with nonhuman primate models.…”

Section: Characterization Of the Rhesus Model: Maternal Componentsmentioning

confidence: 99%

On the role of placental Major Histocompatibility Complex and decidual leukocytes in implantation and pregnancy success using non-human primate models

Golos¹,

Bondarenko²,

Dambaeva³

et al. 2010

Int. J. Dev. Biol.

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While there is broad agreement that interactions of the human maternal immune system with the tissues and cells of the implanting embryo are likely to be critical contributors to pregnancy success, there remains a dearth of information which directly confirms this expectation. Although animal models of reproductive function often provide opportunities for confirming such hypotheses, progress in this area has been sporadic due to limitations of traditional laboratory or agricultural animal models, such as rodents, sheep, pigs and cattle. Many of these limitations derive from divergent modes of implantation and placentation across mammalian species. Over the past decade there has been progress in the development of the nonhuman primate as a model in which to address questions of pregnancy success in the area of immunology. The purpose of this review is to compare available model species, summarize current knowledge and recent progress with an emphasis on experimental in vivo manipulations, and suggest areas available for additional study and growth.

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Selective expression of NKG2-A and NKG2 - C mRNAs and novel alternative splicing of 5′ exons in rhesus monkey decidua

Cited by 12 publications

References 0 publications

Nonhuman primate placental MHC expression: a model for exploring mechanisms of human Maternal-Fetal immune tolerance

Nonhuman primate placental MHC expression: a model for exploring mechanisms of human Maternal-Fetal immune tolerance

Conservation and Variation in Human and Common Chimpanzee CD94 and NKG2 Genes

On the role of placental Major Histocompatibility Complex and decidual leukocytes in implantation and pregnancy success using non-human primate models

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