Selective IgA Deficiency: Clinical and Laboratory Features of 118 Children in Turkey

Aytekin, Caner; Tuygun, Nilden; Gökçe, Selim; Doğu, Figen; İkincioğulları, Aydan

doi:10.1007/s10875-012-9702-3

Cited by 61 publications

(64 citation statements)

References 37 publications

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“…In our stud, all IgA-deficient children manifested cutaneous symptoms of food allergy and while atopic dermatitis occurred in patients with all kinds of hypogammaglobulinemia, solely in IgA-deficient children studied; the correlation between symptoms and immunodeficiency was statistically significant. This finding is consistent with observations also made by other authors who reported an association of impaired antibody production with atopic dermatitis in children [6,18], and which was also found in our previous study [19]. Interestingly, it has been shown recently that cutaneous sensitization may predispose patients to an intestinal allergy by the increased production of thymic stromal lymphopoietin (TSLP) and subsequent T-helper type 2 (Th2)-dependent immune responses to food antigens in the skin [20,21].…”

Section: Discussionsupporting

confidence: 94%

IgA deficiency: a risk factor for food allergy-related atopic dermatitis in infants and young children

Szczawińka-Popłonyk¹,

Komasińska²,

Bręborowicz³

2016

pdia

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A b s t r a c t Introduction:The impaired immunosurveillance and dysfunctional antigen compartmentalization in primary immunodeficiencies may predispose affected children to allergic sensitization. Aim: The growing problem of allergic reactions to foods and the increase in non-IgE-mediated gastrointestinal disorders prompted us to investigate the impact of hypogammaglobulinemia on the prevalence and clinical phenotypes of food allergy. Material and methods:We performed a retrospective analysis of medical records of 78 infants and young children with deficiencies of one or more immunoglobulin isotypes and of 132 age-matched patients with normal immunoglobulin production in terms of prevalence and clinical manifestation of food allergy, atopic sensitization and physical development. Results: The symptoms of allergy to foods were demonstrated with a comparable frequency in children with hypogammaglobulinemia and with normal immunoglobulin levels (51% vs. 48%). The most prominent clinical phenotype of children with hypogammaglobulinemia was atopic dermatitis, whereas in children with normal immunoglobulin production, gastrointestinal symptomatology predominated. Uniquely, IgA deficiency showed a statistically significant (p < 0.05) correlation with food allergy and with cutaneous symptomatology. A striking predominance of non-IgE-mediated food allergy was demonstrated in both groups of the children studied, with elevated serum total IgE levels seen more commonly in children with normogammaglobulinemia than in those with hypogammaglobulinemia. Conclusions: The rate of non-IgE mediated allergic sensitization to foods in the population of infants and young children is high and clinically relevant. A selective IgA deficiency should alert physicians to assess affected children with respect to diverse phenotypes of food allergy.

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Section: Discussionsupporting

confidence: 94%

IgA deficiency: a risk factor for food allergy-related atopic dermatitis in infants and young children

Szczawińka-Popłonyk¹,

Komasińska²,

Bręborowicz³

2016

pdia

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“…However, different studies report different prevalences of autoimmunity in sIgAD. While Shkalim et al [107] reported that 20.6% of IgAD children in Israel showed manifestations of autoimmunity, Edwards et al [108] reported 28%, Aytekin et al [109] reported 17%, and more recently Abolhassani et al [8] reported 29.8%. In this study the most common autoimmune manifestations were thyroiditis, vitiligo, and AIHA, followed by celiac disease, juvenile rheumatoid arthritis, dermatomyositis, autoimmune alopecia, and T1D.…”

Section: Autoimmunity In Padsmentioning

confidence: 99%

Autoimmunity in Primary Antibody Deficiencies

Azizi¹,

Ahmadi²,

Abolhassani³

et al. 2016

Int Arch Allergy Immunol

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Primary antibody deficiencies (PADs) are the most common inherited primary immunodeficiencies in humans, characterized by hypogammaglobulinemia, an inability to produce specific antibodies, and recurrent infections mainly caused by encapsulated bacteria. However, it has been shown that inflammatory disorders, granulomatous lesions, lymphoproliferative diseases, cancer, and autoimmunity are associated with the various types of PAD. Both systemic and organ-specific autoimmune diseases could be attributed to B-cell defects in PAD patients. Immune thrombocytopenic purpura and autoimmune hemolytic anemia are the most common autoimmune disorders in this group of patients. The aim of this review is to describe the proposed mechanisms for autoimmunity and to review the literature with respect to the reported autoimmune disorders in each type of PAD.

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“…Most affected individuals are asymptomatic, whereas approximately one third of patients suffer from recurrent mucosal infections, allergies, and autoimmune diseases (2)(3)(4). Secretory IgA, which is present in mucosal secretions, has a broad protective function, and in the case of sIgAD the mucosa appears to be less protected and more vulnerable to enteric toxins and pathogenic microorganisms (5).…”

Section: Introductionmentioning

confidence: 99%

Allergic and autoimmune disorders in families with selective IgA deficiency

et al. 2017

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Background/aim: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their firstdegree relatives (FDRs). Materials and methods:The study included 81 children diagnosed with sIgAD and 274 of their FDRs. The presence of allergic and autoimmune disorders was evaluated and serum antithyroglobulin and antithyroid peroxidase levels were measured in both patients and their first-degree relatives. Results:The mean age of the patients was 9.9 ± 3.9 years. Among the patients with sIgAD, 45.7% of them had at least one allergic disorder and 17.3% of them had at least one autoimmune disorder. The frequencies of asthma, allergic rhinitis, and eczema in the FDRs of sIgAD patients were 10.9%, 9.1%, and 7.7%, respectively. Among their FDRs, 14.6% had autoimmunity, compared to an estimate of 5% in the general population. Conclusion:Increased frequency of allergic and autoimmune disorders in patients with sIgAD and their FDRs suggests a possible common predisposing genetic component for sIgAD and autoimmunity in these families.

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Selective IgA Deficiency: Clinical and Laboratory Features of 118 Children in Turkey

Cited by 61 publications

References 37 publications

IgA deficiency: a risk factor for food allergy-related atopic dermatitis in infants and young children

IgA deficiency: a risk factor for food allergy-related atopic dermatitis in infants and young children

Autoimmunity in Primary Antibody Deficiencies

Allergic and autoimmune disorders in families with selective IgA deficiency

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