Selective inducible nitric oxide synthase (iNOS) inhibition attenuates remote acute lung injury in a model of ruptured abdominal aortic aneurysm1

Hepatosplanchnic Ischemia/Reperfusion is a Major Determinant of Lung Vascular Injury After Aortic Surgery

“…Indeed, animal experimental studies suggest up-regulation of cytokine production, inducible nitric oxide synthase, mediators of apoptosis, and others in the lungs after gut and/or hepatic ischemia/reperfusion, resulting in increased permeability edema [12,13,20,27,28]. On the other hand, our results may also agree with the studies suggesting that lower body or leg ischemia/reperfusion results in activation of inflammatory factors adversely affecting pulmonary function [17,19,21,23,24].…”

“…The pulmonary changes are believed to be caused, at least in part, by permeability edema of the lungs following release of proinflammatory factors and contributing to acute lung injury/acute respiratory distress syndrome (ALI/ARDS) [4][5][6][7][8][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. The factors may originate from lower body or abdominal organs, subjected to ischemia/reperfusion and subsequent local inflammatory responses, perhaps depending on the type and extent of the vascular surgery [21].…”

Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats

“…In previous studies, aspirations of gastric components lead to activation of macrophages and release of proinflammatory cytokines such as NO. In these animal aspiration models selective iNOS inhibition were prevented lung injury and a significant increase in the metabolism of NO, nitrite and nitrate was also observed in bronchoalveolar lavage fluid of acid-instilled rats or canines [19,[28][29][30][31]. Several animal studies have shown different iNOS activity in lung diseases.…”

The effect of hyperbaric oxygen treatment on aspiration pneumonia

“…In these animal aspiration models selective Kruskal-Wallis test was used for statistical analysis. Values are expressed as means ± SD, n = 10 for each group a P \ 0.05 compared to untreated groups b P \ 0.01 compared to saline control group iNOS inhibition prevented lung injury and a significant increase in the metabolism of NO, nitrite and nitrate was also observed in bronchoalveolar lavage fluid of acidinstilled rats or dogs (Lee et al 1998;Kudoh et al 2001;Miyakawa et al 2002;Speyer et al 2003;Harkin et al 2004). Our data indicate that there is a significant increase in iNOS activity in lung tissue of different aspiration materials such as lipid content formula BIO and especially HCl.…”