Selective induction of IL-6 by aluminum-induced oxidative stress can be prevented by selenium

Vieželienė, Dalė; Beekhof, Piet; Gremmer, Eric R.; Rodovičius, Hiliaras; Sadauskienė, Ilona; Jansen, Eugène; Ivanov, Leonid

doi:10.1016/j.jtemb.2012.11.001

Cited by 24 publications

(18 citation statements)

References 30 publications

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“…One of the functions of IL-6 is an anti-inflammatory action stimulating regeneration and repair through the STAT 3 pathway [17]. It has been suggested that by this pathway IL-6 is involved in the repair process responding to oxidative stress and depletion of reduced glutathione [18,19]. This observation is in agreement with the intracellular decrease in GSH in the brain observed in this study.…”

Section: Discussionsupporting

confidence: 92%

Biomarkers of Selenium Toxicity after Sub-Acute Exposure in Mice

Viezeliene¹

2013

J Mol Biomark Diagn

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Section: Discussionsupporting

confidence: 92%

Biomarkers of Selenium Toxicity after Sub-Acute Exposure in Mice

Viezeliene¹

2013

J Mol Biomark Diagn

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“…In a rat model, Al administration also disrupted the distribution of Se and decreased GPx activity, which increased oxidative damage in target tissues [23]. Al exposure increases oxidative stress and pro-inflammatory cytokine concentrations that are ameliorated by Se treatment [24], whereas Se does not have a protective effect against the toxic effects of Al [41]. …”

Section: Discussionmentioning

confidence: 99%

“…Oxidative phenomena can be triggered by Al, which decreases both Zn and Se status and promotes inflammatory processes in animals [22,23]. In rat models, administering Se or Zn have protected tissues from Al-induced inflammation and oxidative damage [24,25]. Thus, elevated Al concentrations may be related to interactions with Zn and Se and result in a further increase in oxidative stress and inflammation in patients.…”

Section: Introductionmentioning

confidence: 99%

Zinc Supplementation Alters Plasma Aluminum and Selenium Status of Patients Undergoing Dialysis: A Pilot Study

Guo¹,

Chen²,

Hsu³

et al. 2013

Nutrients

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End stage renal disease patients undergoing long-term dialysis are at risk for abnormal concentrations of certain essential and non-essential trace metals and high oxidative stress. We evaluated the effects of zinc (Zn) supplementation on plasma aluminum (Al) and selenium (Se) concentrations and oxidative stress in chronic dialysis patients. Zn-deficient patients receiving continuous ambulatory peritoneal dialysis or hemodialysis were divided into two groups according to plasma Al concentrations (HA group, Al > 50 μg/L; and MA group, Al > 30 to ≤ 50 μg/L). All patients received daily oral Zn supplements for two months. Age- and gender-matched healthy individuals did not receive Zn supplement. Clinical variables were assessed before, at one month, and after the supplementation period. Compared with healthy subjects, patients had significantly lower baseline plasma Se concentrations and higher oxidative stress status. After two-month Zn treatment, these patients had higher plasma Zn and Se concentrations, reduced plasma Al concentrations and oxidative stress. Furthermore, increased plasma Zn concentrations were related to the concentrations of Al, Se, oxidative product malondialdehyde (MDA), and antioxidant enzyme superoxide dismutase activities. In conclusion, Zn supplementation ameliorates abnormally high plasma Al concentrations and oxidative stress and improves Se status in long-term dialysis patients.

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“…B). This indicated that selenium may reduce aluminium toxicity in these cetaceans, as was found for other mammals (Abubakar et al ., ; Viezeliene et al ., 2011; 2013). Similarly, we found that the Al : Zn ratio of the skin was significantly less among the non‐colonized than among the colonized samples (Fig.…”

Section: Resultsmentioning

confidence: 99%

Linking the occurrence of cutaneous opportunistic fungal invaders with elemental concentrations in false killer whale (Pseudorca crassidens) skin

Mouton

Przybyłowicz

Mesjasz‐Przybyłowicz

et al. 2015

Environ Microbiol Rep

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Cetaceans, occupying the top levels in marine food chains, are vulnerable to elevated levels of potentially toxic trace elements, such as aluminium (Al), mercury (Hg) and nickel (Ni). Negative effects associated with these toxic metals include infection by opportunistic microbial invaders. To corroborate the link between the presence of cutaneous fungal invaders and trace element levels, skin samples from 40 stranded false killer whales (FKWs) were analysed using culture techniques and inductively coupled plasma-mass spectroscopy. Twenty-two skin samples yielded 18 clinically relevant fungal species. While evidence for bioaccumulation of Hg in the skin of the FKWs was observed, a strong link was found to exist between the occurrence of opportunistic fungal invaders and higher Al : Se and Al : Zn ratios. This study provides indications that elevated levels of some toxic metals, such as Al, contribute to immunotoxicity rendering FKWs susceptible to colonization by cutaneous opportunistic fungal invaders.

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Selective induction of IL-6 by aluminum-induced oxidative stress can be prevented by selenium

Cited by 24 publications

References 30 publications

Biomarkers of Selenium Toxicity after Sub-Acute Exposure in Mice

Biomarkers of Selenium Toxicity after Sub-Acute Exposure in Mice

Zinc Supplementation Alters Plasma Aluminum and Selenium Status of Patients Undergoing Dialysis: A Pilot Study

Linking the occurrence of cutaneous opportunistic fungal invaders with elemental concentrations in false killer whale (Pseudorca crassidens) skin

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