Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics

Gädke, Johannes; Thies, J.-W.; Kleinfeldt, Lennart; Schulze, Torben; Biedendieck, Rebekka; Rustenbeck, Ingo; Garnweitner, Georg; Krull, Rainer; Dietzel, Andreas

doi:10.1016/j.ejpb.2017.09.008

Cited by 8 publications

(6 citation statements)

References 95 publications

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“…Higher sensitivity with a detection limit of 10 ng/mL [50][51][52] enable capturing, transportation, marking, and detection of biological molecules from physiological samples [38][39][40]. Additionally, the flexibility of functionalization with diverse biological agents makes them an ideal candidate as signaling and capturing material in miniaturized on-chip biosensing systems [41,42].…”

Section: Typesmentioning

confidence: 99%

“…Such magnetic beadbased biochemical detection a system can be applied to ultrasensitive protein detection [43]. Table 2 summarizes useful information about the original state-of-the-art technological advancement in the field of microfluidics [44][45][46][47][48][49][50][51][52]. Currently, intense efforts have been undertaken to develop innovations in handling and manipulation of MNPs in microfluidic devices for future investigation and analysis applications.…”

Section: Typesmentioning

confidence: 99%

“…Such magnetic bead‐based biochemical detection a system can be applied to ultrasensitive protein detection [43]. Table 2 summarizes useful information about the original state‐of‐the‐art technological advancement in the field of microfluidics [44‐52].…”

Section: Introductionmentioning

confidence: 99%

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Magnetic nanoparticles in microfluidic and sensing: From transport to detection

et al. 2020

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Superparamagnetic nanoparticles are attracting significant attention. Therefore, being explored in microsystems for a wide range of applications. Typical examples include labon-a-chip and microfluidics for synthesis, detection, separation, and transportation of different bioanalytes, such as biomolecules, cells, and viruses to develop portable, sensitive, and cost-effective biosensing systems. Particularly, microfluidic systems incorporated with magnetic nanoparticles and, in combination with magnetoresistive sensors, shift diagnostic and analytical methods to a microscale level. In this context, nanotechnology enables the miniaturization and integration of a variety of analytical functions in a single chip for manipulation, detection, and recognition of bioanalytes reliably and flexibly. In consideration of the above, recent development and benefits are elaborated herein to discuss the role of magnetic nanoparticles inside the microchannels to design highly efficient disposable point-of-care applications from transportation to the detection of bioanalytes.

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Section: Typesmentioning

confidence: 99%

Section: Typesmentioning

confidence: 99%

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Magnetic nanoparticles in microfluidic and sensing: From transport to detection

et al. 2020

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“…[18][19][20][21][22][23][24][25][26][27] MNP aggregation produces changes in magnetic and physical properties, which may include an enhanced capacity for rotation and translational movement in response to a dynamic magnetic field. 10,17,[26][27][28] Most MNPs, and certainly MNP aggregates, would be expected to have limited capacity for moving through solid tissue. [29][30][31] However, fluid-filled conduits and reservoirs within the body offer potential avenues for MNP-enhanced drug delivery.…”

Section: Introductionmentioning

confidence: 99%

<p>Rotating Magnetic Nanoparticle Clusters as Microdevices for Drug Delivery</p>

Willis¹,

Pernal²,

Gaertner³

et al. 2020

IJN

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Background: Magnetic nanoparticles (MNPs) hold promise for enhancing delivery of therapeutic agents, either through direct binding or by functioning as miniature propellers. Fluid-filled conduits and reservoirs within the body offer avenues for MNP-enhanced drug delivery. MNP clusters can be rotated and moved across surfaces at clinically relevant distances in response to a rotating magnet. Limited data are available regarding issues affecting MNP delivery by this mechanism, such as adhesion to a cellular wall. Research reported here was initiated to better understand the fundamental principles important for successful implementation of rotational magnetic drug targeting (rMDT). Methods: Translational movements of four different iron oxide MNPs were tested, in response to rotation (3 Hz) of a neodymium-boron-iron permanent magnet. MNP clusters moved along biomimetic channels of a custom-made acrylic tray, by surface walking. The effects of different distances and cellular coatings on MNP velocity were analyzed using videography. Dyes (as drug surrogates) and the drug etoposide were transported by rotating MNPs along channels over a 10 cm distance. Results: MNP translational velocities could be predicted from magnetic separation times. Changes in distance or orientation from the magnet produced alterations in MNP velocities. Mean velocities of the fastest MNPs over HeLa, U251, U87, and E297 cells were 0.24 ± 0.02, 0.26 ± 0.02, 0.28 ± 0.01, and 0.18 ± 0.03 cm/sec, respectively. U138 cells showed marked MNP adherence and an 87.1% velocity reduction at 5.5 cm along the channel. Dye delivery helped visualize the effects of MNPs as microdevices for drug delivery. Dye delivery by MNP clusters was 21.7 times faster than by diffusion. MNPs successfully accelerated etoposide delivery, with retention of chemotherapeutic effect. Conclusion: The in vitro system described here facilitates side-by-side comparisons of drug delivery by rotating MNP clusters, on a human scale. Such microdevices have the potential for augmenting drug delivery in a variety of clinical settings, as proposed.

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“…The average diameters of Fe 3 O 4 -pDMC calculated by nano measure was 11.53 nm (Fig. S1 †).Moreover, the small particle size of Fe 3 O 4 -pDMC (particle size <20 nm) indicated that Fe 3 O 4 -pDMC was a superparamagnetic material [32][33][34]. VSM analysis was conducted to further identify the magnetic properties of Fe 3 O 4 -pDMC, and the results are shown in Fig.S2 †and Table 1.…”

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confidence: 99%

Novel Fe₃O₄–poly(methacryloxyethyltrimethyl ammonium chloride) adsorbent for the ultrafast and efficient removal of anionic dyes

et al. 2021

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Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics

Cited by 8 publications

References 95 publications

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

<p>Rotating Magnetic Nanoparticle Clusters as Microdevices for Drug Delivery</p>

Novel Fe₃O₄–poly(methacryloxyethyltrimethyl ammonium chloride) adsorbent for the ultrafast and efficient removal of anionic dyes

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Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics

Cited by 8 publications

References 95 publications

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

<p>Rotating Magnetic Nanoparticle Clusters as Microdevices for Drug Delivery</p>

Novel Fe3O4–poly(methacryloxyethyltrimethyl ammonium chloride) adsorbent for the ultrafast and efficient removal of anionic dyes

Contact Info

Product

Resources

About

Novel Fe₃O₄–poly(methacryloxyethyltrimethyl ammonium chloride) adsorbent for the ultrafast and efficient removal of anionic dyes