2012
DOI: 10.2174/138527212804004625
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Selective Modifications of Steroids Performed by Oxidative Enzymes

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Cited by 30 publications
(28 citation statements)
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“…Monohydroxylation of testosterone at C11␣ or C15␣ had been discovered in other filamentous fungi [27,28], however hydroxylation at C11␣ was not observed in C. lini ST-1. According to previous reports, allylic hydroxylation at 6␤-position for 4-ene molecules was the predominant steroidal transformation [15,29]. However, no allylic oxidation and no 6␤-hydroxylation were observed among the 4-ene substrates (3 and 4) investigated in this study.…”
Section: Discussionsupporting
confidence: 73%
“…Monohydroxylation of testosterone at C11␣ or C15␣ had been discovered in other filamentous fungi [27,28], however hydroxylation at C11␣ was not observed in C. lini ST-1. According to previous reports, allylic hydroxylation at 6␤-position for 4-ene molecules was the predominant steroidal transformation [15,29]. However, no allylic oxidation and no 6␤-hydroxylation were observed among the 4-ene substrates (3 and 4) investigated in this study.…”
Section: Discussionsupporting
confidence: 73%
“…15 Several studies on the esterification and transesterification of a variety of substrates have shown that lipases are also useful in the steroid field, playing an important role in the mild and selective interconversion of functional groups via regio-and stereoselective transformation. 16,17 Taking into account these properties, in our laboratory we have modified pregnanes and androstanes, 18 synthesized fatty acid derivatives of dehydroepiandrosterone, hydrocortisone and 3,17-β-estradiol, a series of novel 20-succinates of pregnanes and acetyl cortexolone. 19 In the present paper, we want to report the results obtained through lipase-catalyzed esterification, acylation and alcoholysis reactions in the preparation of derivatives of three bile acids: chenodeoxycholic acid (CDCA, 1a), deoxycholic acid (DCA, 2a) and lithocholic acid (LCA, 3a).…”
mentioning
confidence: 99%
“…In recent years, with the increasing consumption of steroid drugs, the use of biotransformation in the production of steroid medicine intermediates has attracted more attention because it is highly efficient, safe, and environmentally friendly (Fernandes et al, 2003;Swizdor et al, 2012). The strain of ZAD stored in our lab could efficiently transform phytosterols to AD and ADD, the most important steroid intermediates.…”
Section: Discussionmentioning
confidence: 99%