"Selective" Pituitary Insufficiency Secondary to Busulfan

Vivacqua, Raymond J.

doi:10.7326/0003-4819-67-2-380

Cited by 25 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This animal model and prior human studies do not support adrenal cortical insufficiency as the cause of zidovudine-induced hyperpigmentation, although the pattern of mucocutaneous hyperpigmentation induced by zidovudine and other drugs, eg, busulfan, is similar to that seen with adrenal cortical insufficiency. 16 Image cytometry proved a useful method to quantify melanin-induced pigmentation in situ. Melanin ap¬ peared first and in the greatest concentration in the basal layer of the epidermis.…”

Section: Resultsmentioning

confidence: 99%

Selective Cutaneous Hyperpigmentation in Mice Following Zidovudine Administration

Obuch

Baker²,

Roth³

et al. 1992

Arch Dermatol

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Selective Cutaneous Hyperpigmentation in Mice Following Zidovudine Administration

Obuch

Baker²,

Roth³

et al. 1992

Arch Dermatol

View full text Add to dashboard Cite

show abstract

“…In some cases, isolated ACTH deficiency appeared secondary to head trauma (22) and as a complication of chemotherapy for myeloproliferative (23,24) and postpartum disorders (15).…”

Section: Discussionmentioning

confidence: 99%

Isolated Adrenocorticotropin Deficiency Associated with Polyglandular Failure

Kojima

Nejima

Ogata

1982

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

A female patient presented with isolated ACTH deficiency and diabetes mellitus. During the course of a year's replacement with hydrocortisone, goiter developed, which, on biopsy, was diagnosed as typical Hashimoto's thyroiditis. Four years later, she experienced tetany, and the diagnosis of idiopathic hypoparathyroidism was made. Immunological studies revealed the presence of antithyroid antibodies in the serum and cell-mediated immunity to the thyroid and parathyroid. These data strongly suggest that the autoimmune process is involved in the genesis of some, though not all, forms of isolated ACTH deficiency.

show abstract

“…In the majority of cases in which endocrine imbalance has been reported in patients undergoing chemotherapy, effects are probably due to the action of the drugs at the pitui-tary15*29, 34,35 or, in the case of amenorrhea, a combination of inhibition of pituitary gonadotrophins and chemical oophorectomy. 14319m The mitotically quiescent cells of the adrenal cortex can, on the basis of this study, probably be excluded as a major target in most cases excepting the aforementioned antimetabolites, thus confirming directly inferences drawn from several clinical s t~d i e s .~~,~~ No confirmation of the proposition, based on animal ~t u d i e s , l *~~ that antimicrotubular agents such as vinblastine can directly stimulate adrenal steroidogenesis was forthcoming from the present study.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic drugs and the human adrenal cortex.A cell culture study

Morgan

O’Hare

1979

Cancer

View full text Add to dashboard Cite

Primary monolayer cultures of nonproliferating adult human adrenocortical cells have been used to screen 18 cytotoxic drugs used in cancer chemotherapy for direct effects on corticosteroidogenesis. None of the drugs tested, with the exception of 5-fluorouracil (5-FU) and its metabolite 5-fluorodeoxyuridine, showed significant activity at levels compatible with cortical cell viability and/ or likely to be encountered during therapy. These two antimetabolites, however, resulted in a slow but long-lived reversible suppression of corticosteroidogenesis in both ACTH-and monobutyryl cyclic AMP-stimulated, as well as unstimulated cultures of human cells. Thus 10 pg/ml resulted in <80% inhibition after seven days treatment without any evidence of overt cytotoxicity. High-pressure liquid chromatography showed a suppression of all UVabsorbing steroids secreted. Examination of the ultrastructure of the treated cells showed significant changes in mitochondria1 morphology, suggesting a possible site of action for the antisteroidogenic effects of 5-fluorouracil. These in vitro results suggest the possibility of adrenal suppression in vivo during long-term or high dose infusion 5-FU chemotherapy.Cancer 43:969-979. 1979.A N Y HUMAN BREAST CANCERS show evi-

show abstract

"Selective" Pituitary Insufficiency Secondary to Busulfan

Cited by 25 publications

References 21 publications

Selective Cutaneous Hyperpigmentation in Mice Following Zidovudine Administration

Selective Cutaneous Hyperpigmentation in Mice Following Zidovudine Administration

Isolated Adrenocorticotropin Deficiency Associated with Polyglandular Failure

Cytotoxic drugs and the human adrenal cortex.A cell culture study

Contact Info

Product

Resources

About