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A 68-year-old female patient diagnosed with lung cancer in the left upper lobe with associated mediastinal adenopathy. The cancer was pathologically diagnosed as stage pT1bN0 typical carcinoid. Investigation of the mediastinal lymph nodes revealed an isolated metastatic non-small cell squamous cell carcinoma (NSCLC). A primary NSCLC was not found. The patient underwent successful surgical resection of both synchronous tumors, with no residual disease or recurrence. This case not only expands the histological field of combined neuroendocrine tumors, but it also highlights the importance of distinguishing various tumor types for disease treatment and prognosis.

A patient with a classical salivary gland benign lymphoepithelial lesion (BLL) that converted to a lymphoblastic lymphoma (LSA) localized to the salivary glands is described. The malignant transformation of the BLL was preceded by Dilantin anticonvulsant therapy, and in vitro tests subsequent to the development of LSA demonstrated positive Dilantin-induced lymphocyte transformation. The lymphoma was treated successfully by local irradiation, chemotherapy, and discontinuation of Dilantin. The case illustrates the "prelymphomatous" nature of BLL in certain patients, as well as the possible potential danger of Dilantin and other lymphoid-stimulating drugs in discussed. Further study of drugs capable lymphocyte transformation in patients with prelymphomatous disorders is warranted.

Familial testicular neoplasia is reported in a father and his son. This represents only the fifth published case of father-son testicular cancer. The father had bilateral testicular seminoma with embryonal cell elements while the son had teratocarcinoma. The clinical significance of familial testicular neoplasia is discussed and the subject of father and son testicular cancer is reviewed. This case of father-son testicular neoplasia illustrates the following important points: 1) there is a continuing need to document and describe each case of familial testicular cancer in order to better evaluate the pathogenesis of this familial occurrence; 2) prospective genetic and laboratory studies will be needed to definitively clarify the specific factors involved in the familial clustering or transmission of this type of cancer; and 3) this tendency for testicular cancer to affect multiple kindred must be considered in the proper guidance and counseling of affected patients and their high-risk family members.