Synchronous Multiple Primary Cancers of the Lung: The Rare Association of Non-Small Cell Carcinoma With a Carcinoid Tumor

Parsi, Meghana; Vivacqua, Raymond J.

doi:10.7759/cureus.9888

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…The non‐small‐cell carcinomas included two adenocarcinomas, one squamous cell carcinoma, one adenosquamous carcinoma plus adenocarcinoma and one adenocarcinoma plus squamous cell carcinoma. In the remaining cases, squamous cell carcinoma was observed in the dissected lymph node with an unknown primary tumour 3 . The remaining six cases were composed of bronchial carcinoid and peripheral adenocarcinoma; small‐cell carcinoma was also observed in one case 4 .…”

Section: Discussionmentioning

confidence: 99%

“…In the remaining cases, squamous cell carcinoma was observed in the dissected lymph node with an unknown primary tumour. 3 The remaining six cases were composed of bronchial carcinoid and peripheral adenocarcinoma; small‐cell carcinoma was also observed in one case. 4 To the best of our knowledge, a combination of bronchial carcinoid and peripheral squamous cell carcinoma was only noted in the current case.…”

Section: Discussionmentioning

confidence: 99%

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Notably small bronchial carcinoid accompanied by peripheral squamous cell carcinoma

Miura¹,

Miura

Goto³

et al. 2021

Respirology Case Reports

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Our report presents the smallest bronchial carcinoid thus far associated with peripheral squamous cell carcinoma. A 79‐year‐old Japanese man presented with an abnormal shadow on chest radiography. Chest computed tomography revealed an ill‐defined nodule at the left S9a area without lymph node involvement. At the time of bronchoscopy, a nodule of ~1 mm in diameter with a smooth surface was observed at the orifice of the left B8. Left lower lobectomy was performed. Pathologically, the S9a tumour was keratinizing squamous cell carcinoma with surgical stage IA3, and the left B8 tumour was a typical bronchial carcinoid. The patient was alive without recurrence 2 years after the surgery. Cases of combined carcinoid and lung cancer are rare. It may be possible to identify bronchial carcinoids early by careful observation of the bronchi during bronchoscopy for peripheral neoplastic lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Notably small bronchial carcinoid accompanied by peripheral squamous cell carcinoma

Miura¹,

Miura

Goto³

et al. 2021

Respirology Case Reports

View full text Add to dashboard Cite

show abstract

“…Despite the aggressive treatment regimen, the half-decade survival metrics offer a somber picture, delineating a survival rate that languishes between 25% and 30%. Sterilized rare earth carbonate (REC) is a mixture of rare earth carbonates and is widely used in various fields such as industry and medicine (12)(13)(14)(15). Due to the high cost-effectiveness and strategic value of RCE, REC is considered an important resource in industrial production.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic efficacy of rare earth carbonate with chemoradiotherapy in late-stage non-small cell lung cancer: a cohort prospective study

Cao,

Ye,

et al. 2023

Front. Endocrinol.

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ObjectiveTo compare the therapeutic effects and adverse reactions of sterilizing rare earth carbonate combined with concurrent chemoradiotherapy and simple concurrent chemoradiotherapy in the treatment of late-stage non-small cell lung cancer (NSCLC), and to analyze the reasons for the differences.MethodA total of 817 patients with pathologically diagnosed late-stage NSCLC from June 1, 2021 to December 30, 2022, in the affiliated hospital of Kunming University of Science and Technology, were selected. They were randomly divided into a control group of 394 people and an experimental group of 423 people. The control group was given concurrent chemoradiotherapy (cisplatin + etoposide), while the experimental group simultaneously took a low dose of sterilized rare earth carbonate (0.05mg/Kg). The χ² test and Fisher’s test were used to compare the clinical pathological features, objective response rate (ORR), ECOG score, and adverse reactions of the two groups of patients, while survival analysis was used to compare the progression-free survival (PFS) of the two groups. Cox regression analysis was used to test factors related to prognosis.ResultsThe differences in clinical pathological features between the two groups of patients were not statistically significant, with all P>0.05. The ORR of the control group was 45.18% (178/394), and the experimental group was 89.83% (380/423), with a statistically significant difference (P=0.001). After treatment, the ECOG score of the experimental group was lower than that of the control group, P<0.001. The adverse reaction grading of patients in both groups was below level 3 after treatment, and no treatment-related fatalities occurred. The risk of pulmonary infection and bone marrow suppression in the experimental group was lower than that in the control group.ConclusionIn late-stage NSCLC patients, compared with simple concurrent chemoradiotherapy, the combination of concurrent chemoradiotherapy and sterilizing rare earth carbonate can significantly improve the short-term therapeutic effect and prognosis of patients, with good safety.

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Synchronous Multiple Primary Cancers of the Lung: The Rare Association of Non-Small Cell Carcinoma With a Carcinoid Tumor

Cited by 2 publications

References 9 publications

Notably small bronchial carcinoid accompanied by peripheral squamous cell carcinoma

Notably small bronchial carcinoid accompanied by peripheral squamous cell carcinoma

Therapeutic efficacy of rare earth carbonate with chemoradiotherapy in late-stage non-small cell lung cancer: a cohort prospective study

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