Selective Preoperative Magnetic Resonance Imaging in Women With Breast Cancer

Weber, João Batista Blessmann; Bellin, Lisa; Milbourn, David E.; Verbanac, Kathryn M.; Wong, Jan H.

doi:10.1001/archsurg.2012.1660

Cited by 27 publications

(20 citation statements)

References 33 publications

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“…The majority of these reports showed no differences 3,10,11,13,15,16 , except for one by Mann et al where a significantly lower rate of re-excision at 5% was seen for patients who received pMRI in comparison to 15% for those who did not. 12 Two recent European randomized trials evaluated the efficacy of pMRI among BC patients.…”

Section: Discussionmentioning

confidence: 94%

Role of Preoperative Magnetic Resonance Imaging in the Surgical Management of Early-Stage Breast Cancer

et al. 2014

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Purpose To examine the role of pre-operative magnetic resonance imaging (pMRI) on time to surgery and rates of re-operation and contralateral prophylactic mastectomy (CPM) using a population-based study of New Jersey breast cancer (BC) patients. Methods The study included 289 African-American and 320 white women who participated in the Breast Cancer Treatment Disparity Study and underwent breast surgery for newly diagnosed early stage BC between 2005 and 2010. Patients were identified through rapid case ascertainment by the New Jersey State Cancer Registry. Association between pMRI and time to surgery was examined using linear regression, and with re-operation and CPM using binomial regression. Results Half (49.9%) of the study population received pMRI, with higher use for whites compared to African-Americans (62.5% versus 37.5%). After adjusting for potential confounders, patients with pMRI than those without, experienced significantly longer time to initial surgery (geometric mean= 38.7 days; 95% confidence interval: 34.8, 43.0 versus 26.5 days; 95% confidence interval: 24.3, 29.0), significantly higher rate of CPM (relative risk [RR]= 1.82; 95% confidence interval: 1.06, 3.12), and non-significant lower rate of re-operation (RR= 0.76; 95% confidence interval [CI]: 0.54, 1.08). Conclusions pMRI was associated with significantly increased time to surgery and higher rate of CPM, but it did not affect the rate of re-operation. Physicians and patients should consider these findings when making surgical decisions based on pMRI findings.

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Section: Discussionmentioning

confidence: 94%

Role of Preoperative Magnetic Resonance Imaging in the Surgical Management of Early-Stage Breast Cancer

et al. 2014

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“…Two of the eligible studies were based on young women 15;16 and another 2 studies 14;26 were based on older women from overlapping datasets (SEER Medicare data in women aged 66 years and older); only one of the 2 overlapping studies was included in each analysis (online Appendix-1 provides additional details). Most studies specified that patients who received neoadjuvant therapy were excluded 14;16;21;22;25;27;30–34 (only one study included patients who had neoadjuvant therapy 15 ). Two studies excluded patients with BRCA gene mutations 23;31 , otherwise this information was not explicitly reported.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of pre-operative magnetic resonance imaging (MRI) and surgical treatment for breast cancer

Houssami

Turner

Morrow

2017

Breast Cancer Res Treat

171

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Background Although there is no consensus on whether pre-operative MRI in women with breast cancer (BC) benefits surgical treatment, MRI continues to be used pre-operatively in practice. This meta-analysis examines the association between pre-operative MRI and surgical outcomes in BC. Methods A systematic review was performed to identify studies reporting quantitative data on pre-operative MRI and surgical outcomes (without restriction by type of surgery received or type of BC) and using a controlled design. Random-effects logistic regression calculated the pooled odds ratio (OR) for each surgical outcome (MRI versus no-MRI groups), and estimated ORs stratified by study-level age. Subgroup analysis was performed for invasive lobular cancer (ILC). Results Nineteen studies met eligibility criteria: 3 RCTs and 16 comparative studies that included newly diagnosed BC of any type except for 3 studies restricted to invasive lobular cancer (ILC). Primary analysis (85975 subjects) showed that pre-operative MRI was associated with increased odds of receiving mastectomy [OR 1.39 (1.23, 1.57); p<0.001]; similar findings were shown in analyses stratified by study-level median age. Secondary analyses did not find statistical evidence of an effect of MRI on the rates of re-excision, re-operation, or positive margins; however MRI was significantly associated with increased odds of receiving contralateral prophylactic mastectomy [OR 1.91 (1.25, 2.91); p= 0.003]. Subgroup analysis for ILC did not find any association between MRI and the odds of receiving mastectomy [OR 1.00 (0.75, 1.33); p= 0.988] or the odds of re-excision [OR 0.65 (0.35, 1.24); p= 0.192]. Conclusions Pre-operative MRI is associated with increased odds of receiving ipsilateral mastectomy and contralateral prophylactic mastectomy as surgical treatment in newly diagnosed BC patients.

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“…We did not correlate our findings with any outcome measure such as re‐excision rates or local recurrence. However, many studies including a randomized clinical trial have not shown that MRI affects re‐excision rates, or recurrence rates . A meta‐analysis of over 3,000 patients also did not show that preoperative MRI reduced risk of local or distant recurrence compared to patients who did not get MRI .…”

Section: Discussionmentioning

confidence: 95%

Clinical accuracy of preoperative breast MRI for breast cancer

Tseng

Kyrillos

Liederbach

et al. 2017

Journal of Surgical Oncology

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Selective Preoperative Magnetic Resonance Imaging in Women With Breast Cancer

Abstract: The use of preoperative magnetic resonance (MR) imaging may have an effect on the reoperation rate in women with operable breast cancer.

Cited by 27 publications

References 33 publications

Role of Preoperative Magnetic Resonance Imaging in the Surgical Management of Early-Stage Breast Cancer

Role of Preoperative Magnetic Resonance Imaging in the Surgical Management of Early-Stage Breast Cancer

Meta-analysis of pre-operative magnetic resonance imaging (MRI) and surgical treatment for breast cancer

Clinical accuracy of preoperative breast MRI for breast cancer

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