Selective radiofrequency ablation of tumor by magnetically targeting of multifunctional iron oxide–gold nanohybrid

Beyk, Jaber; Tavakoli, Hassan

doi:10.1007/s00432-019-02969-1

Cited by 15 publications

(16 citation statements)

References 36 publications

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“…Actually, two types of sources are generally recognized: (1) inductively coupled device that produces an alternating magnetic field (MF) inside a solenoid and (2) capacitively coupled device that produces an alternating electric field between parallel-plates [ 57 ]. Magnetic NPs, e.g., iron oxide NPs, could be stimulated by the MF, whereas non-magnetic ones, e.g., gold NPs, seem to be more responsive to electric fields [ 58 ]. For these reasons, magnetic and non-magnetic NP-mediated RF-hyperthermia are sometimes identified as two different approaches, e.g., as proposed by Beik, nanomagnetic hyperthermia (NMH) and nano-radio-frequency ablation (NaRFA) [ 59 ].…”

Section: Radiofrequency Responding Npsmentioning

confidence: 99%

“…Magnetic heating refers to the capability of magnetic NPs to generate heat under a magnetic stimulation. In the case of gold nanomaterials, they could become magnetic after a chemical oxidation [ 58 ]. Electrophoretic heating instead is due to the movement of charged species on the gold NPs surface because of the variations of the electric field: this effect causes the oscillation of the NPs and generates heat through mechanical friction [ 20 , 58 ].…”

Section: Radiofrequency Responding Npsmentioning

confidence: 99%

“…In the case of gold nanomaterials, they could become magnetic after a chemical oxidation [ 58 ]. Electrophoretic heating instead is due to the movement of charged species on the gold NPs surface because of the variations of the electric field: this effect causes the oscillation of the NPs and generates heat through mechanical friction [ 20 , 58 ]. The predominance of a mechanism over the other is probably associated to the features of the experimental setup, regarding both the RF source and the NPs [ 20 ].…”

Section: Radiofrequency Responding Npsmentioning

confidence: 99%

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Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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Cancer has nowadays become one of the leading causes of death worldwide. Conventional anticancer approaches are associated with different limitations. Therefore, innovative methodologies are being investigated, and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell death. The idea is to conjugate two different components, i.e., an external physical input and nanoparticles. Both are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest, thus also limiting the negative outcomes for the surrounding tissues. Tuning both the properties of the nanomaterial and the involved triggering stimulus, it is possible furthermore to achieve not only a therapeutic effect, but also a powerful platform for imaging at the same time, obtaining a nano-theranostic application. In the present review, we highlight the role of nanoparticles as therapeutic or theranostic tools, thus excluding the cases where a molecular drug is activated. We thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and nanoparticles. We perform a special focus on mechanical waves responding nanoparticles, in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

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Section: Radiofrequency Responding Npsmentioning

confidence: 99%

Section: Radiofrequency Responding Npsmentioning

confidence: 99%

Section: Radiofrequency Responding Npsmentioning

confidence: 99%

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Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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“…Cell viability was determined using the SRB analysis after incubated with 24 h, 48 h, and 72 h in 37 °C for a CO 2 atmosphere. The MFL underwent the same process without irradiation (Pantano et al., 2017 ; Chung et al., 2018 ; Prasad et al., 2018 ; Beyk & Tavakoli, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Synergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy

Zhang

et al. 2022

Drug Delivery

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The field of biomedical research has recently been interested in nanoplatforms with various functionalities, such as cancer drug carriers and MRI and optical imaging, as well as thermal treatment, among other things. As a result of the present investigation, a unique multifunctional liposome (MFL) was established in this investigation. Using radiofrequency-induced imaging and drug release based on magnetic field impact, a dual drug delivery targeted with tumor multi-mechanism treatment was made more effective. The C60 (fullerene) surface was coated with iron nanocomposites to establish the proposed nanosystems, and PEGylation was used (Fe 3 O 4 -C60-PEG 2000 ). For fullerene radiofrequency-triggered drug release, thermosensitive DPPC liposomes with folate-DSPE-PEG 2000 enveloped the binary nanosystems and doxorubicin (DOX). The in vitro cytotoxicity of the nanocomposites was confirmed by the liver metastasis in HT-29 colon cancer cells using radiofrequency. The flow cytometry analysis confirmed the apoptosis cell death mechanism. The thermal treatment combined chemotherapeutic MFL nano framework transformed radiofrequency radiation from thermoresponsive liposomes, which was noticed both in vivo and in vitro . Due to their superior active tumor targeting and magnetic targeting characteristics, the MFL could also selectively destroy cancerous liver cells in highly co-localized targets.

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“…[ 79 ] Furthermore, the properties of the NM itself can be employed in the targeted treatment of tumors for example through exploitation of the NM photothermal properties for the use in PTT. The enhanced photothermal properties of different NMs have been utilized in the development of a variety of noninvasive CRC tumor ablation strategies including radiofrequency‐based therapy [ 80 ] and NIR alone [ 81 ] or in combination with chemotherapeutic drug delivery. [ 82–84 ] Multimodal theranostics (coupling of in vivo diagnostics with therapy) represent attractive prospects for the future development of more effective anticancer interventions.…”

Section: Nanomedicines Designed For Targeting and Treatment Of Cancersmentioning

confidence: 99%

A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges

Kermanizadeh

Jacobsen

Murphy

et al. 2020

Advanced Therapeutics

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The design and utilization of nanomedicines offers great potential for treating various diseases including cancers. Current challenges with traditional cancer treatment strategies include but are not limited to lack of specific targeting, overt systemic toxicity and low efficacy. The use of nanomaterials show particular promise as candidates for cancer treatment due to their high surface to volume ratio and tuneable size, shape, and surface chemistry, which in combination, allow for improved tumor targeting and enhanced therapeutic efficacy. The scrutinization of the literature demonstrates the potential of nanosized carrier systems over traditional approaches (at the molecular level) for specific targeting of the tumors. Despite the great promise showing in preclinical studies, the number of nanomedicines reaching clinical testing is still very low. This review attempts to address this issue by using a weight of evidence approach to the different strategies for use of nanomedicines in combating cancer, as well as highlighting a number of areas that the field of nanomedicines is clearly lagging behind in, as compared to conventional drug discovery and development. It is hoped that the recommendations in this review will allow for better translation of nanomedicines reaching clinical trials.

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Selective radiofrequency ablation of tumor by magnetically targeting of multifunctional iron oxide–gold nanohybrid

Cited by 15 publications

References 36 publications

Remotely Activated Nanoparticles for Anticancer Therapy

Remotely Activated Nanoparticles for Anticancer Therapy

Synergic fabrication of multifunctional liposomes nanocomposites for improved radiofrequency ablation combination for liver metastasis cancer therapy

A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges

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