Selective rather than universal screening for gestational diabetes mellitus?

Miailhe, G.; Kayem, Gilles; Girard, G.; Legardeur, Hélène; Mandelbrot, Laurent

doi:10.1016/j.ejogrb.2015.05.003

Cited by 47 publications

(38 citation statements)

References 47 publications

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“…The frequency of hypertension in subjects with GDM differed from the control group, being higher (14.9% vs 4.8%, respectively, P = 0.007). GDM group also had a higher family history of DM (approximately 70%) when compared with Euro-descendant healthy pregnant women from Portugal (16%) (27) and France (19%) (28). The median (control vs GDM) of fasting glucose and 2-h, 75g glucose, 84 (79-88) vs 88 (81-95) mg/dL and 86.2 (79-102) vs 161.0 (149-176) mg/dL, showed higher concentration in GDM group (P < 0.001).…”

Section: Resultsmentioning

confidence: 99%

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Anghebem-Oliveira

Martins

Alberton

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO) rs1421085, leptin receptor (LEPR) rs1137100, rs1137101, peroxisome proliferator-activated receptor gamma (PPARg) rs1801282, and transcription factor 7-like 2 (TCF7L2) rs7901695 with GDM. Subjects and methods: 252 unrelated Euro-Brazilian pregnant women were classified into two groups according to the 2015 criteria of the American and Brazilian Diabetes Association: healthy pregnant women (n = 125) and pregnant women with GDM (n = 127), matched by age. The polymorphisms were genotyped using fluorescent probes (TaqMan ® ). Results: All groups were in Hardy-Weinberg equilibrium. The genotype and allele frequencies of the studied polymorphisms did not show significant differences between the groups (P > 0.05). In the healthy and GDM groups, the C allele frequencies (95% CI) of the FTO rs1421085 polymorphism were 36.8% [31-43%]

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Section: Resultsmentioning

confidence: 99%

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Anghebem-Oliveira

Martins

Alberton

et al. 2017

Arch. Endocrinol. Metab.

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“…In Denmark, selective screening for diabetes in pregnant women is performed with an oral glucose tolerance test in case of glycosuria or if the woman has other known risk factors . Such selective screening approach will, however, not identify all cases of diabetes in pregnancy . The high risk of pregnancy loss in women with diabetes observed in the present study adds to the hypothesis that insufficiently treated or undetected and untreated maternal endocrine disease was an underlying mechanism in the increased risk of pregnancy loss in diabetes as well as in hypo‐ and hyperthyroidism.…”

Section: Discussionmentioning

confidence: 62%

Hypothyroidism and pregnancy loss: comparison with hyperthyroidism and diabetes in a Danish population‐based study

Andersen

Olsen

Laurberg

2016

Clinical Endocrinology

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“…GDM patients were older (median age 32 vs 30 years) and heavier (BMI 32.6 vs 26.1 kg/m 2 ) compared with healthy pregnant controls. A history of family diabetes was high in the GDM group (66.7%) when compared to other Euro-descendent healthy pregnant women from Portugal (16%) (Ribeiro et al, 2015) and France (16%) (Miailhe et al, 2015). This information for the control group was not available.…”

Section: Resultsmentioning

confidence: 87%

Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes

et al. 2017

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ABSTRACT. Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. Women with gestational diabetes are at moderate risk of developing diabetes type 1 and 2 after pregnancy, in addition to complications to the fetus. We investigated the association of the polymorphisms rs7799039 (LEP) and rs13266634 (SLC30A8) in a case-control study in Euro-Brazilians with gestational diabetes (GDM, N = 180). Realtime PCR with fluorescent probes (TaqMan system) was applied to genotyping. All polymorphisms were in Hardy-Weinberg equilibrium. The minor allele frequencies, for healthy and GDM, respectively, for the A-allele (LEP gene rs7799039) were 40.3% (95%CI = 35-45%) vs 36.6% (95%CI = 31-42%), P = 0.345; and for the T-allele (SLC30A8 gene rs13266634) were 27.8% (95%CI = 23-32%) vs 23.5% (95%CI = 18-29%), P = 0.227. Genotype comparisons for both polymorphisms showed no significant difference (P > 0.05). The polymorphisms rs7799039 and rs13266634 were not associated with GDM in the population studied (P > 0.05). The minor allele frequencies for both polymorphisms were similar to those of other Caucasian populations.

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Selective rather than universal screening for gestational diabetes mellitus?

Cited by 47 publications

References 47 publications

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Hypothyroidism and pregnancy loss: comparison with hyperthyroidism and diabetes in a Danish population‐based study

Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes

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