Selective removal of common cyanotoxins: a review

Wang, Shulian; Jiao, Yiying; Rao, Zihe

doi:10.1007/s11356-021-13798-6

Cited by 9 publications

(8 citation statements)

References 111 publications

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“…The Microcystis aeruginosa. FACHB905 was selected as the experimental object of algae killing in an expanded environment system; it had the largest frequency and amplitude of cyanobacterial blooms . Furtherly, we explored whether A3 with high algicidal activity in the microenvironment (96-well micro plate) had the same level of activity in the extended environmental system (100 mL culture system).…”

Section: Methodsmentioning

confidence: 99%

Design, Synthesis, and Mode of Action of Thioacetamide Derivatives as the Algicide Candidate Based on Active Substructure Splicing Strategy

Huang,

Zuo,

Zhang

et al. 2024

J. Agric. Food Chem.

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Lakes and reservoirs worldwide are experiencing a growing problem with harmful cyanobacterial blooms (HCBs), which have significant implications for ecosystem health and water quality. Algaecide is an effective way to control HCBs effectively. In this study, we applied an active substructure splicing strategy for rapid discovery of algicides. Through this strategy, we first optimized the structure of the lead compound S5, designed and synthesized three series of thioacetamide derivatives (series A, B, C), and then evaluated their algicidal activities. Finally, compound A3 with excellent performance was found, which accelerated the process of discovering and developing new algicides. The biological activity assay data showed that A3 had a significant inhibitory effect on M. aeruginosa. FACHB905 (EC 50 = 0.46 μM) and Synechocystis sp. PCC6803 (EC 50 = 0.95 μM), which was better than the commercial algicide prometryn (M. aeruginosa. FACHB905, EC 50 = 6.52 μM; Synechocystis sp. PCC6803, EC 50 = 4.64 μM) as well as better than lead compound S5 (M. aeruginosa. FACHB905, EC 50 = 8.80 μM; Synechocystis sp. PCC6803, EC 50 = 7.70 μM). The relationship between the surface electrostatic potential, chemical reactivity, and global electrophilicity of the compounds and their activities was discussed by density functional theory (DFT). Physiological and biochemical studies have shown that A3 might affect the photosynthesis pathway and antioxidant system in cyanobacteria, resulting in the morphological changes of cyanobacterial cells. Our work demonstrated that A3 might be a promising candidate for the development of novel algicides and provided a new active skeleton for the development of subsequent chemical algicides.

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Section: Methodsmentioning

confidence: 99%

Design, Synthesis, and Mode of Action of Thioacetamide Derivatives as the Algicide Candidate Based on Active Substructure Splicing Strategy

Huang,

Zuo,

Zhang

et al. 2024

J. Agric. Food Chem.

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“…Their cyclic structure confers resistance to degradation at high temperatures and pH values. Rapid chemical hydrolysis occurs in highly acidic conditions (HCl 6 mol L –1 ) at temperatures ≥40 °C. ,, …”

Section: Microcystinsmentioning

confidence: 99%

“…Rapid chemical hydrolysis occurs in highly acidic conditions (HCl 6 mol L −1 ) at temperatures ≥40 °C. 9,49,50 Freshwater bodies affected by cyanobacterial bloom can be treated through conventional methods, 51,52 but the total removal of algae biomass and the associated MCs cannot be fully achieved. 41 MC-contaminated water is odorless and tasteless, and these cyanotoxins are not destroyed by cooking.…”

Section: ■ Microcystinsmentioning

confidence: 99%

Microcystins Detection Methods: A Focus on Recent Advances Using Molecularly Imprinted Polymers

et al. 2021

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“…Activated carbon (AC) is among the commonly used adsorbents for effective MC removal, due to its porous nature and large specific surface area [18]. Several studies have shown that AC adsorption is extensively applied for removal of residual organic pollutants, including dissolved MCs from water sources, due to its high mesoporosity [21].…”

Section: Introductionmentioning

confidence: 99%

Adsorbents Used for Microcystin Removal from Water Sources: Current Knowledge and Future Prospects

et al. 2022

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The increasing occurrence of toxic cyanobacteria in water sources, driven by climate change and eutrophication, is of great concern worldwide today. Cyanobacterial blooms can negatively affect water bodies and generate harmful secondary metabolites, namely microcystins (MCs), which significantly impair water quality. Various adsorbents used for MC removal from water sources were assessed in this investigation. Activated carbon constitutes the most widely used adsorbent for treating contaminated waters due to its high affinity for adsorbing MCs. Alternative adsorbents have also been proposed and reported to provide higher efficiency, but the studies carried out so far in this regard are still insufficient. The mechanisms implicated in MC adsorption upon different adsorbents should be further detailed for a better optimization of the adsorption process. Certainly, adsorbent characteristics, water pH and temperature are the main factors influencing the adsorption of MCs. In this context, optimization studies must be performed considering the effectiveness, economic aspects associated with each adsorbent. This review provides guidelines for more practical field applications of the adsorption in the treatment of waters actually contaminated with MCs.

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Selective removal of common cyanotoxins: a review

Cited by 9 publications

References 111 publications

Design, Synthesis, and Mode of Action of Thioacetamide Derivatives as the Algicide Candidate Based on Active Substructure Splicing Strategy

Design, Synthesis, and Mode of Action of Thioacetamide Derivatives as the Algicide Candidate Based on Active Substructure Splicing Strategy

Microcystins Detection Methods: A Focus on Recent Advances Using Molecularly Imprinted Polymers

Adsorbents Used for Microcystin Removal from Water Sources: Current Knowledge and Future Prospects

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