2012
DOI: 10.2147/ijn.s28242
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Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles

Abstract: Background: Nanoparticle-based systems are promising for the development of imaging and therapeutic agents. The main advantage of nanoparticles over traditional systems lies in the possibility of loading multiple functionalities onto a single molecule, which are useful for therapeutic and/or diagnostic purposes. These functionalities include targeting moieties which are able to recognize receptors overexpressed by specific cells and tissues. However, targeted delivery of nanoparticles requires an accurate syst… Show more

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Cited by 33 publications
(9 citation statements)
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References 45 publications
(70 reference statements)
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“…Two different groups have attempted cell-specific targeting of melanoma cells in vivo, demonstrating methods that could potentially reduce systemic toxicity in chemotherapeutic drug delivery. Alpha-melanocyte stimulating hormone has been conjugated to human ferritin nanoparticles; this approach demonstrated in vivo melanoma tumor-accumulation at 24 hours (31). Another group used EP1, a monoclonal antibody to the human melanoma-specific antigen CSPG4, conjugated to a single ferritin cage and encapsulating cisplatin (32).…”
Section: Discussionmentioning
confidence: 99%
“…Two different groups have attempted cell-specific targeting of melanoma cells in vivo, demonstrating methods that could potentially reduce systemic toxicity in chemotherapeutic drug delivery. Alpha-melanocyte stimulating hormone has been conjugated to human ferritin nanoparticles; this approach demonstrated in vivo melanoma tumor-accumulation at 24 hours (31). Another group used EP1, a monoclonal antibody to the human melanoma-specific antigen CSPG4, conjugated to a single ferritin cage and encapsulating cisplatin (32).…”
Section: Discussionmentioning
confidence: 99%
“…Vannucci et al. [ 86 ] incubated ferritin with methoxypolyethylene glycol maleimide to prepare PEGylated ferritin nanocage, which showed more persistent circulation. Kang et al.…”
Section: Functional Modifications Of Ferritin-based Nanoparticle Drug...mentioning
confidence: 99%
“…[ 89 ] fused RGD4C peptide, ligand of α v β 3 integrins upregulated on tumor vasculature, to the N-terminal of human H-ferritin subunit, incorporating it on the exterior surface of ferritin, which resulted in enhanced melanoma targeting ability. α-melanocyte-stimulating hormone peptide was also fused to the N-terminal of ferritin subunit and displayed at the outer surface, which significantly enhanced ferritin’s ability to target melanoma [ 86 ]. Lee et al.…”
Section: Functional Modifications Of Ferritin-based Nanoparticle Drug...mentioning
confidence: 99%
“…By adding targeting moieties to the external surface of ferritin, the encapsulated molecules can be delivered in a site-specific manner. Additionally, the outer surface of ferritin can be engineered to impart increased circulatory half-life (e.g., PEG [ 69 ], PAS polypeptides [ 70 ]) and, most importantly, to trigger specific cellular responses (e.g., antigens, antibodies, nucleotides) [ 14 ]. In the following sections, functionalization of the outer surface of ferritin will be thoroughly described since this interface enables antigen presentation for the development of ferritin-based vaccines ( Figure 3 ).…”
Section: Functionalization Of Ferritin Nanoparticlesmentioning
confidence: 99%