Selective three-phase liquid phase microextraction of acidic compounds from foodstuff simulants

Rodríguez, A.; Pedersen‐Bjergaard, Stig; Rasmussen, Knut; Nerı́n, Cristina

doi:10.1016/j.chroma.2008.05.032

Cited by 38 publications

(16 citation statements)

References 28 publications

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“…Similar to the pH of donor phase, the pH of the acceptor phase can also affect extraction efficiency. Therefore, the acceptor pH should be adjusted to pH values where the analytes are highly charged [17] and thereby fully trapped in the acceptor phase [18].…”

Section: Adjustment Of Phmentioning

confidence: 99%

Determination of partition coefficient and analysis of nitrophenols by three‐phase liquid‐phase microextraction coupled with capillary electrophoresis

Sanagi

Miskam

Ibrahim

et al. 2010

J of Separation Science

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A three-phase hollow fiber liquid-phase microextraction method coupled with CE was developed and used for the determination of partition coefficients and analysis of selected nitrophenols in water samples. The selected nitrophenols were extracted from 14 mL of aqueous solution (donor solution) with the pH adjusted to pH 3 into an organic phase (1-octanol) immobilized in the pores of the hollow fiber and finally backextracted into 40.0 microL of the acceptor phase (NaOH) at pH 12.0 located inside the lumen of the hollow fiber. The extractions were carried out under the following optimum conditions: donor solution, 0.05 M H(3)PO(4), pH 3.0; organic solvent, 1-octanol; acceptor solution, 40 microL of 0.1 M NaOH, pH 12.0; agitation rate, 1050 rpm; extraction time, 15 min. Under optimized conditions, the calibration curves for the analytes were linear in the range of 0.05-0.30 mg/L with r(2)>0.9900 and LODs were in the range of 0.01-0.04 mg/L with RSDs of 1.25-2.32%. Excellent enrichment factors of up to 398-folds were obtained. It was found that the partition coefficient (K(a/d)) values were high for 2-nitrophenol, 3-nitrophenol, 4-nitrophenol, 2,4-dinitrophenol and 2,6-dinitrophenol and that the individual partition coefficients (K(org/d) and K(a/org)) promoted efficient simultaneous extraction from the donor through the organic phase and further into the acceptor phase. The developed method was successfully applied for the analysis of water samples.

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Section: Adjustment Of Phmentioning

confidence: 99%

Determination of partition coefficient and analysis of nitrophenols by three‐phase liquid‐phase microextraction coupled with capillary electrophoresis

Sanagi

Miskam

Ibrahim

et al. 2010

J of Separation Science

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show abstract

“…In single drop based three-phase LPME, the analytes are first extracted from an aqueous sample matrix into an organic phase immiscible with water and located on top of the aqueous phase, followed by back-extraction into a separate microdrop of aqueous phase suspended from the tip of a microsyringe and penetrating into the organic phase [24]. In recent years, an alternative concept of LPME has been introduced based on the use of single, low-cost, disposable and porous hollow fibers made of polypropylene to support the organic phase in the pores of the wall while holding the second aqueous phase in the lumen of the fiber [31][32][33][34][35][36][37][38]. This mode of hollow fiber liquid phase microextraction (HF-LPME) is limited to the basic or acidic analytes with ionizable functionalities.…”

Section: Pioglitazone ([(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy] Phementioning

confidence: 99%

Extraction of trace amounts of pioglitazone as an anti-diabetic drug with hollow fiber liquid phase microextraction and determination by high-performance liquid chromatography-ultraviolet detection in biological fluids

Tahmasebi

Yamini

Saleh

2009

Journal of Chromatography B

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“…Low cost of the hollow fibre enables to dispose each extraction unit after a single extraction and thus to exclude cross-contamination problems from sample to sample and to avoid the need of regeneration of the extraction unit. HFLPME has been successfully applied for the determination of drugs [13,14], aromatic amines [15,16], pesticides [17,18], phthalates [19], parabens [20], aromatic carboxylic acids [21], phenols [21] and essential oils [22,23].…”

Section: Introductionmentioning

confidence: 99%

Dispersion‐solidification liquid–liquid microextraction for volatile aromatic hydrocarbons determination: Comparison with liquid phase microextraction based on the solidification of a floating drop

Vičkačkaitė

Pusvaskiene

2009

J of Separation Science

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Two microextraction techniques--liquid phase microextraction based on solidification of a floating organic drop (LPME-SFO) and dispersive liquid-liquid microextraction combined with a solidification of a floating organic drop (DLLME-SFO)--are explored for benzene, toluene, ethylbenzene and o-xylene sampling and preconcentration. The investigation covers the effects of extraction solvent type, extraction and disperser solvents' volume, and the extraction time. For both techniques 1-undecanol containing n-heptane as internal standard was used as an extracting solvent. For DLLME-SFO acetone was used as a disperser solvent. The calibration curves for both techniques and for all the analytes were linear up to 10 microg/mL, correlation coefficients were in the range 0.997-0.998, enrichment factors were from 87 for benzene to 290 for o-xylene, detection limits were from 0.31 and 0.35 microg/L for benzene to 0.15 and 0.10 microg/L for o-xylene for LPME-SFO and DLLME-SFO, respectively. Repeatabilities of the results were acceptable with RSDs up to 12%. Being comparable with LPME-SFO in the analytical characteristics, DLLME-SFO is superior to LPME-SFO in the extraction time. A possibility to apply the proposed techniques for volatile aromatic hydrocarbons determination in tap water and snow was demonstrated.

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Selective three-phase liquid phase microextraction of acidic compounds from foodstuff simulants

Cited by 38 publications

References 28 publications

Determination of partition coefficient and analysis of nitrophenols by three‐phase liquid‐phase microextraction coupled with capillary electrophoresis

Determination of partition coefficient and analysis of nitrophenols by three‐phase liquid‐phase microextraction coupled with capillary electrophoresis

Extraction of trace amounts of pioglitazone as an anti-diabetic drug with hollow fiber liquid phase microextraction and determination by high-performance liquid chromatography-ultraviolet detection in biological fluids

Dispersion‐solidification liquid–liquid microextraction for volatile aromatic hydrocarbons determination: Comparison with liquid phase microextraction based on the solidification of a floating drop

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