Selective TRAIL‐induced cytotoxicity to lung cancer cells mediated by miRNA response elements

Wu, Guodong; Ji, Zhiyong; Li, Haifeng; Yu, Lei; Jin, Xiaoyuan; Yu, Yingqing; Sun, Mingli

doi:10.1002/cbf.3042

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…Prx1 induces TRAIL ( tumor necrosis factor–related apoptosis-inducing ligand ) resistance by suppressing the redox-dependent activation of caspase [90]. TRAIL is a biological agent that induces apoptosis of cancer cells and is considered a promising anticancer agent [91]. Down-regulation of Prx1 using RNA interference or chemical agents like dioscin results in the induction of apoptosis in tumor cells [92; 93].…”

Section: The Srx-prx Axis In Tumorigenesis and Cancer Progressionmentioning

confidence: 99%

The sulfiredoxin–peroxiredoxin (Srx–Prx) axis in cell signal transduction and cancer development

Mishra¹,

Jiang²,

Wu³

et al. 2015

Cancer Letters

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Redox signaling is a critical component of cell signaling pathways that is involved in regulation of cell growth, metabolism, hormone signaling, immune regulation and variety of other physiological functions. Peroxiredoxin (Prx) is a family of thiol-based peroxidases that acts as a regulator of redox signaling. Members of Prx family can act as antioxidants and chaperone. Sulfiredoxin (Srx) is an antioxidant protein that exclusively reduces over-oxidized typical 2-Cys Prx. Srx have different affinities for individual Prx and it also catalyzes deglutathionylation of variety of substrates. Individual components of Srx-Prx system play critical roles in carcinogenesis by modulating cell signaling pathway involved in cell proliferation, migration and metastasis. Expression levels of individual components of Srx-Prx axis has been correlated with patient survival outcome in multiple cancer types. This review will summarize the molecular basis of differences in affinity of Srx for individual Prx and the role of individual components of Srx-Prx system in tumor progression and metastasis. This enhanced understanding of molecular aspects of Srx-Prx interaction and its role in cell signal transduction will help in defining Srx-Prx system as a future therapeutic target in human cancer.

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Section: The Srx-prx Axis In Tumorigenesis and Cancer Progressionmentioning

confidence: 99%

The sulfiredoxin–peroxiredoxin (Srx–Prx) axis in cell signal transduction and cancer development

Mishra¹,

Jiang²,

Wu³

et al. 2015

Cancer Letters

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show abstract

“…As the incidence of lung adenocarcinoma has rapidly increased, it has become a major pathological type of lung cancer. 4 Revealing the molecular pathogenesis of lung adenocarcinoma may enable improvement in the diagnosis and treatment of this disease.…”

Section: Introductionmentioning

confidence: 99%

miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells

et al. 2015

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MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators involved in various biological and pathological processes of cells, but their association with tumor chemoresistance has not been fully understood. We detected miR-15b expression in two lung adenocarcinoma cell lines, A549 and A549/CDDP, and then investigated the effects of miR-15b on the metastasis and the chemosensitivity of cancer cells, using both gain- and loss-of-function studies. The correlation between miR-15b level and chemoresistance was further investigated in clinical lung adenocarcinoma specimens. miR-15b was significantly upregulated in cisplatin-resistant lung adenocarcinoma A549/CDDP cells compared with parental A549 cells. miR-15b regulates epithelial-mesenchymal transition (EMT) and cisplatin resistance in vitro and modulates response of lung adenocarcinoma cells to cisplatin in vivo. Further studies identified phosphatidylethanolamine-binding protein 4 (PEBP4) as a direct and functional target of miR-15b. Small-interfering RNA-mediated PEBP4 knockdown revealed similar effects as that of ectopic miR-15b expression, whereas overexpression of PEBP4 attenuated the function of miR-15b in lung adenocarcinoma cells. Increased miR-15b expression was also detected in tumor tissues sampled from lung adenocarcinoma patients treated with cisplatin-based chemotherapy and was proved to be correlated with low expression of PEBP4, decreased sensitivity to cisplatin and poor prognosis. Our results suggest that upregulation of miR-15b could suppress PEBP4 expression and in turn contribute to chemoresistance of lung adenocarcinoma cells to cisplatin.

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“…Resistance occurs when certain genetic or epigenetic changes make the treatment ineffective against the tumor cells [ 174 , 175 ]. MiR-221 and miR-222 were first discovered to be involved in the development of some epithelial cancers [ 176 ]. Subsequently, these two miRNAs were found to be upregulated in NSCLC and further investigation revealed that they regulate the tumor suppressors PTEN and TIMP3 [ 177 ].…”

Section: Research Focused On Therapeutic Applicationsmentioning

confidence: 99%

Decoding the Emerging Patterns Exhibited in Non-coding RNAs Characteristic of Lung Cancer with Regard to Their Clinical Significance

Sonea

Buse

Gulei

et al. 2018

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Lung cancer continues to be the leading topic concerning global mortality rate caused by can-cer; it needs to be further investigated to reduce these dramatic unfavorable statistic data. Non-coding RNAs (ncRNAs) have been shown to be important cellular regulatory factors and the alteration of their expression levels has become correlated to extensive number of pathologies. Specifically, their expres-sion profiles are correlated with development and progression of lung cancer, generating great interest for further investigation. This review focuses on the complex role of non-coding RNAs, namely miR-NAs, piwi-interacting RNAs, small nucleolar RNAs, long non-coding RNAs and circular RNAs in the process of developing novel biomarkers for diagnostic and prognostic factors that can then be utilized for personalized therapies toward this devastating disease. To support the concept of personalized medi-cine, we will focus on the roles of miRNAs in lung cancer tumorigenesis, their use as diagnostic and prognostic biomarkers and their application for patient therapy.

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Selective TRAIL‐induced cytotoxicity to lung cancer cells mediated by miRNA response elements

Cited by 4 publications

References 33 publications

The sulfiredoxin–peroxiredoxin (Srx–Prx) axis in cell signal transduction and cancer development

The sulfiredoxin–peroxiredoxin (Srx–Prx) axis in cell signal transduction and cancer development

miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells

Decoding the Emerging Patterns Exhibited in Non-coding RNAs Characteristic of Lung Cancer with Regard to Their Clinical Significance

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