Selective α-oxidation of amides via visible-light-driven iron catalysis

Abstract

The hydroxyl radical (•OH) as one of the highly reactive species can react unselectively with a wide range of chemicals. The •OH radicals are typically generated from harsh conditions. Herein,...

Photocatalytic aerobic α-oxygenation of amides to imides using a highly durable decatungstate tetraphenylphosphonium salt

“…17 Nevertheless, these methods require stoichiometric amounts of reactants, resulting in a high environmental impact. Therefore, the direct synthesis of imides through α-oxygenation of amides has garnered considerable attention 18 because of its reduced number of reaction steps, use of various readily available amide structures, and the potential for using O 2 as an oxidant under mild conditions, particularly when combined with photocatalysis. Several photocatalytic systems have been explored for this reaction; however, there are still challenges, such as limited substrate scope, excessive oxidant usage, and prolonged reaction time (Table S1, ESI†).…”

“…Several photocatalytic systems have been explored for this reaction; however, there are still challenges, such as limited substrate scope, excessive oxidant usage, and prolonged reaction time (Table S1, ESI†). 12,18…”